Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules

内布拉斯加州通过膳食分子预防肥胖病中心

• 批准号: 8904674
• 负责人: JANOS ZEMPLENI
• 金额: $ 220.19万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-05 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8904674
• 关键词: Address; American; Area; Biochemistry; Bioinformatics; Biological; Biostatistics Core; Cardiovascular Diseases; Centers of Research Excellence; Charge; Clinical; Clinical Research; Core Facility; Development; Diabetes Mellitus; Diet; Disease; Environment; Epidemic; Epigenetic Process; Faculty; Funding; Goals; Grant; Health; Health Care Costs; Healthcare Systems; High Prevalence; Human; Immunology; Industry; Instruction; Intake; Interdisciplinary Study; Intervention; Investigation; Laboratories; Link; Liver diseases; Medical; Medical center; Mentors; Meta-Analysis; Molecular Biology; NIH Program Announcements; Nebraska; Nutrient; Obesity; Obesity associated disease; Outcome; Personal Satisfaction; Phase; Prevention; Prevention strategy; Program Development; Recommendation; Research; Research Personnel; Research Priority; Research Project Grants; Signal Pathway; Signal Transduction; Staging; Strategic Planning; Stress; Talents; Targeted Research; Techniques; Training; Translating; Translational Research; United States; Universities; Vision; base; clinical practice; combat; community setting; consumer behavior; cost; cost effective; data sharing; economic impact; food science; health economics; health organization; improved; innovation; meetings; multidisciplinary; non-alcoholic fatty liver; novel strategies; nutrition; obesity prevention; prevent; programs; research data dissemination; response; salt intake; saturated fat; success; tool development; user-friendly

The University of Nebraska-Lincoln, in partnership with the University of Nebraska Medical Center, proposes to establish the Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules (NPOD) as a Center of Biomedical Research Excellence. NPOD will unite research strengths in nutrient signaling to develop junior faculty talent and utilize novel approaches in discovery-based research and translation to combat the growing epidemic of obesity-related disorders through consumer-friendly and cost-efficient intervention strategies, beginning with a focus on cardiovascular disease, diabetes, and non-alcoholic fatty liver disease. NPOD will create a nationally recognized center charged with developing and sustaining a critical mass of investigators dedicated to obesity research and leverage Center discoveries to devise and implement effective strategies for the prevention of obesity-related diseases through the dietary manipulation of nutrient signaling pathways. The Center's goals will be accomplished through three specific aims to: (1) establish an administrative core and programs to support and enhance NPOD research; (2) develop a critical mass of faculty through the support of five thematically linked primary research projects, a vigorous mentoring program for Project Leaders, a pilot grant program, a Molecular Biology, Bioinformatics and Biostatistics Core facility, and a research tool development program in the Core; and (3) increase research capacity through targeted recruitment of researchers in areas key to Center success. NPOD's world-class, multidisciplinary research environment will be instrumental in supporting the development of strategies to prevent cardiovascular disease, diabetes, and non-alcoholic fatty liver disease; creating a skilled workforce in a national priority area; implementing techniques for translating discoveries in the laboratory to inform clinical practice and influence consumer behavior; and utilizing innovative approaches to instant sharing of research data and dissemination of recommendations for consumers. NPOD investigators bring the breadth of expertise necessary to accomplish the Center's grand vision and share the common tenant that obesity-related diseases can be prevented through the manipulation of nutrient signaling pathways and that this prevention strategy is attractive and accessible to consumers, thus holding great potential for long-term national impact.

内布拉斯加州大学林肯分校与内布拉斯加大学医学中心合作， 建议建立内布拉斯加州饮食预防肥胖病中心 分子(NPOD)作为生物医学研究的卓越中心。NPOD将联合研究力量 在营养信号方面发展初级教员人才，并在基于发现的基础上利用新的方法 研究和翻译，通过对消费者友好的方式对抗日益流行的肥胖相关疾病 和具有成本效益的干预策略，从关注心血管疾病开始， 糖尿病和非酒精性脂肪性肝病。NPOD将创建全国公认的充电中心 培养和维持一支致力于肥胖症研究和 利用中心的发现来设计和实施有效的策略来预防与肥胖相关的疾病 通过饮食对营养信号通路的操纵来控制疾病。该中心的目标将是 通过三个具体目标来实现：(1)建立行政核心和方案，以 支持和加强NPOD研究；(2)通过五个方面的支持，培养一支足够多的教师队伍 与主题相关的主要研究项目，针对项目负责人的有力指导计划，试点 格兰特计划，一个分子生物学、生物信息学和生物统计学的核心设施，以及一个研究工具 核心发展方案；和(3)通过有针对性地招聘以下人员来提高研究能力 中心成功的关键领域的研究人员。NPOD世界一流的多学科研究环境 将有助于支持制定预防心血管疾病的战略， 糖尿病和非酒精性脂肪性肝病；在国家优先领域培养熟练劳动力； 实施将实验室中的发现转化为临床实践和 影响消费者行为；并利用创新方法即时共享研究数据和 传播对消费者的推荐。NPOD调查人员带来了广泛的专业知识 有必要实现该中心的宏伟愿景，并分享与肥胖相关的共同租户 疾病可以通过操纵营养信号通路来预防，这一点 预防策略对消费者具有吸引力和可及性，因此具有巨大的长期潜力 对全国的影响。