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Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules

内布拉斯加州通过膳食分子预防肥胖病中心

基本信息

批准号：
9272412
负责人：
JANOS ZEMPLENI
金额：
$ 219.62万
依托单位：
UNIVERSITY OF NEBRASKA LINCOLN
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-05 至 2019-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9272412
关键词：
Address American Area Biochemistry Bioinformatics Biological Biology Biostatistics Core Cardiovascular Diseases Centers of Research Excellence Charge Clinical Clinical Research Core Facility Development Diabetes Mellitus Diet Disease Environment Epidemic Epigenetic Process Faculty Funding Goals Grant Health Health Care Costs Healthcare Systems High Prevalence Human Immunology Instruction Intake Interdisciplinary Study Intervention Investigation Laboratories Link Medical Medical center Mentors Meta-Analysis Molecular Biology NIH Program Announcements Nebraska Nutrient Obesity Obesity associated disease Outcome Phase Prevention Prevention strategy Program Development Recommendation Recruitment Activity Research Research Personnel Research Priority Research Project Grants Signal Pathway Signal Transduction Strategic Planning Stress Talents Targeted Research Techniques Training Translating Translational Research Translations United States United States National Institutes of Health Universities Vision base clinical practice combat community setting consumer behavior cost effective cost efficient data sharing dietary manipulation disorder prevention economic impact food science health economics health organization improved industry partner innovation multidisciplinary non-alcoholic fatty liver novel strategies nutrition obesity prevention prevent programs research data dissemination response salt intake saturated fat success tool development user-friendly

项目摘要

The University of Nebraska-Lincoln, in partnership with the University of Nebraska Medical Center, proposes to establish the Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules (NPOD) as a Center of Biomedical Research Excellence. NPOD will unite research strengths in nutrient signaling to develop junior faculty talent and utilize novel approaches in discovery-based research and translation to combat the growing epidemic of obesity-related disorders through consumer-friendly and cost-efficient intervention strategies, beginning with a focus on cardiovascular disease, diabetes, and non-alcoholic fatty liver disease. NPOD will create a nationally recognized center charged with developing and sustaining a critical mass of investigators dedicated to obesity research and leverage Center discoveries to devise and implement effective strategies for the prevention of obesity-related diseases through the dietary manipulation of nutrient signaling pathways. The Center's goals will be accomplished through three specific aims to: (1) establish an administrative core and programs to support and enhance NPOD research; (2) develop a critical mass of faculty through the support of five thematically linked primary research projects, a vigorous mentoring program for Project Leaders, a pilot grant program, a Molecular Biology, Bioinformatics and Biostatistics Core facility, and a research tool development program in the Core; and (3) increase research capacity through targeted recruitment of researchers in areas key to Center success. NPOD's world-class, multidisciplinary research environment will be instrumental in supporting the development of strategies to prevent cardiovascular disease, diabetes, and non-alcoholic fatty liver disease; creating a skilled workforce in a national priority area; implementing techniques for translating discoveries in the laboratory to inform clinical practice and influence consumer behavior; and utilizing innovative approaches to instant sharing of research data and dissemination of recommendations for consumers. NPOD investigators bring the breadth of expertise necessary to accomplish the Center's grand vision and share the common tenant that obesity-related diseases can be prevented through the manipulation of nutrient signaling pathways and that this prevention strategy is attractive and accessible to consumers, thus holding great potential for long-term national impact.

内布拉斯加大学林肯分校与内布拉斯加大学医学中心合作，