Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules

内布拉斯加州通过膳食分子预防肥胖病中心

• 批准号: 9272412
• 负责人: JANOS ZEMPLENI
• 金额: $ 219.62万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-05 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9272412
• 关键词: Address; American; Area; Biochemistry; Bioinformatics; Biological; Biology; Biostatistics Core; Cardiovascular Diseases; Centers of Research Excellence; Charge; Clinical; Clinical Research; Core Facility; Development; Diabetes Mellitus; Diet; Disease; Environment; Epidemic; Epigenetic Process; Faculty; Funding; Goals; Grant; Health; Health Care Costs; Healthcare Systems; High Prevalence; Human; Immunology; Instruction; Intake; Interdisciplinary Study; Intervention; Investigation; Laboratories; Link; Medical; Medical center; Mentors; Meta-Analysis; Molecular Biology; NIH Program Announcements; Nebraska; Nutrient; Obesity; Obesity associated disease; Outcome; Phase; Prevention; Prevention strategy; Program Development; Recommendation; Recruitment Activity; Research; Research Personnel; Research Priority; Research Project Grants; Signal Pathway; Signal Transduction; Strategic Planning; Stress; Talents; Targeted Research; Techniques; Training; Translating; Translational Research; Translations; United States; United States National Institutes of Health; Universities; Vision; base; clinical practice; combat; community setting; consumer behavior; cost effective; cost efficient; data sharing; dietary manipulation; disorder prevention; economic impact; food science; health economics; health organization; improved; industry partner; innovation; multidisciplinary; non-alcoholic fatty liver; novel strategies; nutrition; obesity prevention; prevent; programs; research data dissemination; response; salt intake; saturated fat; success; tool development; user-friendly

The University of Nebraska-Lincoln, in partnership with the University of Nebraska Medical Center, proposes to establish the Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules (NPOD) as a Center of Biomedical Research Excellence. NPOD will unite research strengths in nutrient signaling to develop junior faculty talent and utilize novel approaches in discovery-based research and translation to combat the growing epidemic of obesity-related disorders through consumer-friendly and cost-efficient intervention strategies, beginning with a focus on cardiovascular disease, diabetes, and non-alcoholic fatty liver disease. NPOD will create a nationally recognized center charged with developing and sustaining a critical mass of investigators dedicated to obesity research and leverage Center discoveries to devise and implement effective strategies for the prevention of obesity-related diseases through the dietary manipulation of nutrient signaling pathways. The Center's goals will be accomplished through three specific aims to: (1) establish an administrative core and programs to support and enhance NPOD research; (2) develop a critical mass of faculty through the support of five thematically linked primary research projects, a vigorous mentoring program for Project Leaders, a pilot grant program, a Molecular Biology, Bioinformatics and Biostatistics Core facility, and a research tool development program in the Core; and (3) increase research capacity through targeted recruitment of researchers in areas key to Center success. NPOD's world-class, multidisciplinary research environment will be instrumental in supporting the development of strategies to prevent cardiovascular disease, diabetes, and non-alcoholic fatty liver disease; creating a skilled workforce in a national priority area; implementing techniques for translating discoveries in the laboratory to inform clinical practice and influence consumer behavior; and utilizing innovative approaches to instant sharing of research data and dissemination of recommendations for consumers. NPOD investigators bring the breadth of expertise necessary to accomplish the Center's grand vision and share the common tenant that obesity-related diseases can be prevented through the manipulation of nutrient signaling pathways and that this prevention strategy is attractive and accessible to consumers, thus holding great potential for long-term national impact.

内布拉斯加大学林肯分校与内布拉斯加大学医学中心合作， 建议建立内布拉斯加州中心，通过饮食预防肥胖疾病 分子（NPOD）作为生物医学研究卓越中心。NPOD将联合研究力量 在营养信号，以发展初级教师人才，并利用新的方法，在发现为基础的 研究和翻译，通过消费者友好的方式， 和具有成本效益的干预策略，从关注心血管疾病开始， 糖尿病和非酒精性脂肪肝。NPOD将建立一个国家认可的中心， 发展和维持一批致力于肥胖研究的关键调查人员， 利用中心的发现，设计和实施有效的策略，预防肥胖相关的 通过饮食控制营养信号通路来预防疾病。中心的目标将 通过三个具体目标来实现：（1）建立一个行政核心和方案， 支持和加强NPOD研究;（2）通过五个支持发展教师的临界质量 主题相关的主要研究项目，为项目负责人提供有力的指导计划， 资助计划，分子生物学，生物信息学和生物统计学核心设施，以及研究工具 核心发展计划;（3）通过有针对性地招募 研究人员在中心成功的关键领域。NPOD世界一流的多学科研究环境 将有助于支持制定预防心血管疾病的战略， 糖尿病和非酒精性脂肪肝;在国家优先领域培养熟练的劳动力; 实施将实验室发现转化为临床实践的技术， 影响消费者行为;利用创新方法即时共享研究数据， 为消费者提供建议。NPOD调查人员带来了广泛的专业知识 必须完成该中心的宏伟愿景，并分享共同的租户，肥胖有关 疾病可以通过操纵营养信号途径来预防， 预防战略对消费者具有吸引力和可获得性，因此具有长期的巨大潜力。 全国影响。