权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules

内布拉斯加州通过膳食分子预防肥胖病中心

基本信息

批准号：
10650141
负责人：
JANOS ZEMPLENI
金额：
$ 233.08万
依托单位：
UNIVERSITY OF NEBRASKA LINCOLN
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-05 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10650141
关键词：
Address Adult American Area Award Basic Science Biochemistry Bioinformatics Biological Biomedical Research Center for Translational Science Activities Centers of Research Excellence Chemical Engineering Clinical Clinical Research Clinical Sciences Collaborations Communication Complement Consultations Data Analytics Development Dietitian Disease Ensure Environment Epidemic Equipment Europe Evaluation Experimental Designs Faculty Fee-for-Service Plans Funding Gases Gastroenterology Goals Grant Health Health Food Home Human Individual Inflammation Infrastructure Institution Intervention Investments Laboratories Laboratory Animals Malignant Neoplasms Medical Care Costs Medical center Mentors Metabolic Diseases National Institute of Diabetes and Digestive and Kidney Diseases Nebraska Obesity Obesity associated disease Overweight Peer Review Phase Play Positioning Attribute Process Public Health Publications Quality of life Records Reproducibility Research Research Infrastructure Research Personnel Research Support Secure Series Services Signal Transduction Specialist Strategic Planning Structure Training Translating Translational Research Travel Treatment Cost United States United States National Institutes of Health Universities Vision Visit Wages clinical translation cohort combat community based participatory research community based research cost design dietary exosome foodborne improved lipid metabolism member metabolic abnormality assessment multidisciplinary non-alcoholic fatty liver disease nutrition nutritional genomics obesity prevention prevent professor programs recruit square foot statistics success symposium

项目摘要

PROJECT SUMMARY/ABSTRACT The Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules (NPOD) supports research on the identification of biological signals that prevent, treat, and cure obesity and related diseases. The emphasis of NPOD is on food-borne signals. Led by the University of Nebraska-Lincoln (UNL) in close collaboration with the University of Nebraska Medical Center (UNMC), NPOD investigators have their tenure homes in 16 units crossing basic and clinical sciences, including nutrition, chemical engineering, biochemistry, gastroenterology, and public health, making NPOD a truly multidisciplinary endeavor. NPOD’s long-term goal is to enhance the biomedical research infrastructure in Nebraska while combating obesity, a major health problem impacting U.S. citizens. NPOD’s Centers of Biomedical Research Excellence (COBRE) Phase 1 successes include over $96M in external funding awards to support research and 375 scholarly publications on the center’s theme. Ten junior investigators have been mentored through two cohorts, with four of the five Cohort 1 project leaders graduating from NPOD support and establishing themselves as independent investigators within the center. The fifth project leader departed for a position in Europe prior to graduation. Cohort 2’s five project leaders are in the middle of their mentoring period. The hire of four new faculty during Phase 1 enabled the center to lay the groundwork to build a critical mass of researchers: NPOD’s membership has grown from 13 faculty at the center’s inception to its current count of 51 investigators. During Phase 1, NPOD renovated space and added equipment worth over $1M to create the Biomedical and Obesity Research Core comprised of an Obesity and Nutrition Laboratory (1,976 sq. ft.) and Animal Laboratory (606 sq. ft.). An Administrative Core provides oversight of program activities to ensure the center functions effectively. NPOD’s many successes in Phase 1 have positioned it to leverage Phase 2 COBRE funding and institutional commitments (e.g., five new hires, approximately $1.2M toward start-up packages, and over $1M in cash matches) via strategic activities designed to maximize center success. Specifically, during Phase 2 NPOD will 1) increase its critical mass of researchers with an additional five junior investigator hires at UNL and UNMC (and a nutrigenomics investigator hire through UNL’s Programs of Excellence), recruiting new junior and senior investigators to the center using pilot and seed grant funding, and continuing to develop strategic alliances with complementary programs in Nebraska; 2) acquire additional equipment for the Research Core and enhance rigor and reproducibility with statistics and bioinformatics consultations offered through the Administrative Core; 3) enhance the center’s mentoring structure and collaborative, multidisciplinary environment through the addition of external mentors and various center activities; and 4) expand integration of fundamental nutrition and obesity research with translational clinical and community-based research. By the completion of Phase 2, NPOD will be on-track for transitioning into COBRE Phase 3 and pursuit of NPOD’s vision to become an NIH-designated Nutrition and Obesity Research Center.

项目总结/文摘