B WELL MOM ANALYSIS 2020

B WELL MOM 分析 2020

• 批准号: 10200238
• 负责人: MICHAEL TSAI
• 金额: $ 83.38万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10200238
• 关键词: Adipocytes; Affect; Air Pollutants; Air Pollution; Alabama; Asthma; Blood specimen; Buffers; C-Peptide; Chronic Disease; Clinical; Collaborations; Contractor; DNA; Data Coordinating Center; Enrollment; Epidemiology; Exposure to; First Pregnancy Trimester; Flow Cytometry; Folic Acid; Galactosylceramides; Glucosylceramides; Glutathione; Government; Hypersensitivity; Immune; Immune response; Immune system; Laboratories; Leptin; Lipids; Lung Inflammation; Measures; Molecular Weight; National Institute of Child Health and Human Development; Nose; Nucleic Acids; Oxidative Stress; Oxides; Peroxidases; Pilot Projects; Plasma; Postpartum Period; Predictive Factor; Pregnancy; Pregnant Women; Process; Prospective cohort study; RNA; Sampling; Serum; Severities; Specimen; Superoxide Dismutase; Swab; Symptoms; Testing; Testosterone; Tissues; Tumor Necrosis Factor Receptor; Umbilical Cord Blood; Universities; Urine; Visit; Vitamin D; Woman; Work; adiponectin; adverse pregnancy outcome; asthmatic; clinical center; dietary antioxidant; experience; fatty acid-binding proteins; follow-up; immune function; improved; microbiome; nucleic acid purification; pregnancy immunology; preservation; receptor; recruit; repository; resistin

The B-WELL-Mom Study, a multicenter prospective cohort study, aims to increase understanding of factors that predict poor asthma control during pregnancy, and that add to our knowledge of the basic immunology of pregnancy. Asthma is a common chronic disease. It affects about 9 out of 100 pregnant women and is associated with adverse pregnancy outcomes. We know that one-third of all pregnant women with asthma experience worsening symptoms throughout pregnancy, while one-third improve. However, the reason for this change is not known. The maternal immune response to pregnancy suggests that humoral immune responses are preserved, and that allergy may be an important predictor in determining the clinical course of pregnant women with asthma. We will examine in-depth immune function and lung inflammation to assess the impact of immune regulatory processes throughout pregnancy and the postpartum period that may be associated with changes in asthma control. Daily exposure to air pollutants provides another challenge to the maternal immune system, both for women with and without asthma. Among asthmatics, the change in severity/control may be differentially affected by external factors including air pollution and dietary antioxidants. This study will recruit a total of 500 women in their first trimester of pregnancy (less than 14 weeks gestation) and follows them through 4 months postpartum. Recruitment will target 200 women with good asthma control and 200 women with poorly controlled asthma in the year prior to pregnancy, in addition to 100 non-asthmatic women. The B-WELL-Mom Study is being conducted by the DIPHR Epidemiology Branch in collaboration with two clinical centers at the University of Alabama at Birmingham, and Northwestern University; a Data Coordinating Center at the Emmes Corporation; the NICHD Repository; and a laboratory. Over 400 women are enrolled and more than 300 of them had delivered by June 2018. Enrollment will end in August 2018 and postpartum follow-up visits are expected to end in September 2019.

B-WELL-Mom研究是一项多中心前瞻性队列研究，旨在增加对孕期哮喘控制不良的预测因素的理解，并增加我们对孕期基本免疫学的了解。