SUICIDE AND MATERNAL IMMUNE ACTIVITY

背景和导言 在怀孕期间，引起免疫反应的母体不良事件与后代的神经精神疾病有关。促炎细胞因子和抗炎细胞因子之间的不平衡被认为是儿童神经精神疾病风险的一种机制。 2013年，美国有41，149人死于自杀。同年，自杀是10至14岁儿童的第三大死因，是15至24岁儿童的第二大死因。自杀预防策略有效性的证据并不令人信服。此外，对自杀病因学缺乏了解限制了我们预测谁处于最大风险的能力。 这项研究将把1959-1966年美国围产期合作项目（CPP）参与者所生的52,966名儿童的数据与国家死亡指数联系起来，确定他们到2013年的生命状态，并调查自杀未遂的产前、社会经济、行为、认知和神经风险。我们将进行一项巢式病例对照研究，以调查妊娠期免疫活性对胎儿自杀起源的贡献。 校内人群健康研究部（DIPHR）在NICHD-DIPHR库中从CPP参与者中确定了2371份血清标本，我们将比较自杀死亡的后代和匹配的非自杀对照组之间的免疫系统生物标志物水平。我们假设这些组之间存在系统性差异模式，病例显示生物标志物浓度模式与母体免疫系统扰动一致。 范围 本任务单应使用Q-PlexTM人类细胞因子HS筛查（针对15种细胞因子）和其他检测试剂盒来检测免疫系统标志物，包括但不限于IL-8和hsCRP。

BACKGROUND AND INTRODUCTION During pregnancy, adverse maternal events that mount an immune response have been linked with neuropsychiatric disorders in the offspring. An imbalance between pro- and anti-inflammatory cytokines is suggested as a contributing mechanism to a child’s risk of neuropsychiatric disorders. In 2013, 41,149 individuals died by suicide in the United States. In that year, suicide was the third leading cause of death among children aged 10 to 14, and the second leading cause of death between the ages of 15 and 24. Evidence for the effectiveness of suicide prevention strategies are not convincingly positive. Moreover, a lack of understanding of suicide etiology limits our ability to predict who is at the greatest risk. This study shall link data from 52,966 children born to participants in the United States Collaborative Perinatal Project (CPP) between 1959-1966 to the National Death Index, determine their vital status through 2013, and investigate the prenatal, socioeconomic, behavioral, cognitive, and neurologic risks for completed suicide. We shall conduct a nested case-control study to investigate the contributions of gestational immune activity to fetal origins of suicide. The Division of Intramural Population Health Research (DIPHR) has identified 2371 serum specimens in the NICHD-DIPHR repository from CPP participants for which we shall compare levels of immune system biomarkers between offspring who died by suicide and a matched group of non-suicide controls. We hypothesize that there shall be a systematic pattern of differences between these groups, with cases exhibiting a pattern of biomarker concentrations consistent with a perturbation of the maternal immune system. SCOPE This task order shall use a Q-PlexTM Human Cytokine HS Screen (for 15 cytokines) and additional assays to detect immune system markers including but not limited to IL-8 and hsCRP.