IDIQ BASE BIOMEDICAL ASSAY LABORATORY FOR THE DIVISION OF POPULATION HEALTH RESEARCH - PROJECT TRACKING AND CONSULTATION

IDIQ 人口健康研究部生物医学检测实验室 - 项目跟踪和咨询

• 批准号: 10703545
• 负责人: MICHAEL TSAI
• 金额: $ 2.16万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-12 至 2032-09-11
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10703545
• 关键词: Adipose tissue; Adolescent; Adult; Antioxidants; Biocompatible Materials; Biological; Biological Assay; Biological Markers; Blood; C-reactive protein; Caring; Carotenoids; Child Development; Child Health; Clinical; Collection; Concentration measurement; Consultations; Contractor; Contracts; DNA; Data; Development; Enzyme-Linked Immunosorbent Assay; Etiology; Fatty Acids; Follicular Fluid; Gene Chips; Glucose; Growth and Development function; Hair; Health; Health behavior; Heavy Metals; Hormones; Human; Immune system; Infant; Intervention Studies; Laboratories; Longevity; Measurement; Measures; Metabolic; Methylation; Nail plate; National Institute of Child Health and Human Development; Newborn Infant; Nutritional; Observational Study; Omentum; Personal Satisfaction; Placenta; Plasma; Pregnant Women; Principal Investigator; Proteomics; Protocols documentation; RNA; Reproduction; Research; Research Activity; Research Design; Research Project Grants; Saliva; Scientist; Seminal fluid; Services; Ships; Specimen; Spottings; Study Subject; Techniques; Testing; Tissues; Tocopherols; Triglycerides; Umbilical Cord Blood; Urine; Whole Blood; adolescent health; base; cytokine; design; dietary; epidemiology study; exome sequencing; flexibility; genome wide association study; immune function; innovation; leptin receptor; metabolomics; microbiome analysis; population health; repository; reproductive; research study; sample collection; steroid hormone

The Division of Population Health Research (DiPHR) conducts research on a variety of topics pertaining to human reproduction and development, child and adolescent health and behavior, and care of pregnant women, among other topics. Both observational and interventional research studies are designed and are implemented by DiPHR scientists, and most research includes collection of a diverse array of data and biospecimens. All biospecimens are collected using approved protocols and are de-identified prior to banking in NICHD-supported repositories. The contractor shall receive no identifying or personal health information about the study subjects. A wide range of specimen types are collected including whole blood, cord blood, buffy coats, plasma, serum, urine, saliva, tissues (e.g., placenta, omental fat), hair, nail clippings, follicular and seminal fluid, semen, and newborn blood spots. DiPHR requires analysis of this diverse collection of specimen types for a multitude of factors, including concentrations of reproductive and other hormones; dietary biomarkers; cytokines; indicators of metabolic function including analysis of fatty acids, triglycerides, and glucose; immune function markers; low levels of C-reactive protein; as well as extraction of DNA for whole exome sequencing and methylation analysis; RNA isolation for use in expression arrays; and microbiome analysis. DiPHR requires analysis of collected biological specimens including blood (plasma, serum, WBC, etc.), urine, saliva, adipose tissue, follicular fluid, seminal fluid, and other biologic material relevant for specific research initiatives. Proposed analyses include measurement of concentrations of steroid hormones; measurement of heavy metals; measurement of antioxidants and other nutritional markers including carotenoids, tocopherols, leptin, and leptin receptor; measurement of immune system markers; the flexibility to measure different analytes using multiplex and ELISA techniques; and quantification of metabolomics, proteomics, and genome-wide association studies. DiPHR designs and conducts innovative etiologic and interventional research from preconception through adulthood, focusing on successful reproduction, the health and well-being of pregnant women and their infants, and the optimal growth and development of children and adolescents across the lifespan. To accomplish this, the Division generates a collection of de-identified human biospecimens pertaining to these research activities. The Division requires the services of a biomedical laboratory to provide validated, clinical analyses of biospecimens as well as to modify and/or develop new analysis as needed to measure these biological specimens.

人口健康研究司就与人类生殖和发育、儿童和青少年健康和行为、孕妇护理等有关的各种专题进行研究。观察性和干预性研究都是由DiPHR的科学家设计和实施的，大多数研究包括收集各种数据和生物标本。 所有生物标本均采用经批准的方案收集，并在存入NICHD支持的储存库之前进行去识别。承包商不得收到任何关于研究受试者的身份或个人健康信息。收集广泛的样本类型，包括全血、脐带血、血沉棕黄层、血浆、血清、尿液、唾液、组织（例如，胎盘、网膜脂肪）、毛发、指甲剪、卵泡液和精液、精液和新生儿血斑。 DiPHR需要分析多种因素的标本类型，包括生殖激素和其他激素的浓度;饮食生物标志物;细胞因子;代谢功能指标，包括脂肪酸，甘油三酯和葡萄糖的分析;免疫功能标志物;低水平的C反应蛋白;以及提取DNA进行全外显子组测序和甲基化分析;用于表达阵列的RNA分离;和微生物组分析。 DiPHR需要分析采集的生物样本，包括血液（血浆、血清、WBC等），尿液、唾液、脂肪组织、卵泡液、精液和其他与特定研究计划相关的生物材料。建议的分析包括测量类固醇激素的浓度;测量重金属;测量抗氧化剂和其他营养标志物，包括类胡萝卜素，生育酚，瘦素和瘦素受体;测量免疫系统标志物;使用多重和ELISA技术测量不同分析物的灵活性;以及代谢组学，蛋白质组学和全基因组关联研究的定量。 DiPHR设计并开展了从孕前到成年的创新病因学和干预性研究，重点关注成功生殖，孕妇及其婴儿的健康和福祉，以及儿童和青少年在整个生命周期的最佳生长和发育。为实现这一目标，该司收集了与这些研究活动有关的去识别人类生物标本。该司需要一个生物医学实验室提供服务，对生物样本进行经过验证的临床分析，并根据需要修改和（或）开发新的分析方法，以测量这些生物样本。