IDIQ BASE BIOMEDICAL ASSAY LABORATORY FOR THE DIVISION OF POPULATION HEALTH RESEARCH - PROJECT TRACKING AND CONSULTATION

IDIQ 人口健康研究部生物医学检测实验室 - 项目跟踪和咨询

• 批准号: 10905961
• 负责人: MICHAEL TSAI
• 金额: $ 2.19万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-12 至 2029-09-11
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10905961
• 关键词: Adipose tissue; Adolescent; Adult; Antioxidants; Behavior; Biocompatible Materials; Biological; Biological Assay; Biological Markers; Blood; C-reactive protein; Caring; Carotenoids; Child Development; Child Health; Clinical; Clip; Collection; Concentration measurement; Conceptions; Consultations; Contractor; Contracts; DNA; Data; Development; Enzyme-Linked Immunosorbent Assay; Etiology; Fatty Acids; Follicular Fluid; Gene Chips; Glucose; Growth and Development function; Hair; Health; Heavy Metals; Hormones; Human; Immune system; Infant; Intervention Studies; Laboratories; Leptin; Longevity; Measurement; Measures; Metabolic; Methylation; Nail plate; National Institute of Child Health and Human Development; Newborn Infant; Nutritional; Observational Study; Omentum; Personal Satisfaction; Placenta; Plasma; Pregnant Women; Principal Investigator; Proteomics; Protocols documentation; RNA; Reproduction; Research; Research Activity; Research Design; Research Project Grants; Saliva; Scientist; Seminal fluid; Serum; Services; Specimen; Spottings; Study Subject; Techniques; Testing; Tissues; Tocopherols; Triglycerides; Umbilical Cord Blood; Urine; Whole Blood; adolescent health; base; cytokine; design; dietary; epidemiology study; exome sequencing; flexibility; genome wide association study; immune function; innovation; leptin receptor; metabolomics; microbiome analysis; population health; repository; reproductive; research study; sample collection; steroid hormone

The Division of Population Health Research (DiPHR) conducts research on a variety of topics pertaining to human reproduction and development, child and adolescent health and behavior, and care of pregnant women, among other topics. Both observational and interventional research studies are designed and are implemented by DiPHR scientists, and most research includes collection of a diverse array of data and biospecimens. All biospecimens are collected using approved protocols and are de-identified prior to banking in NICHD-supported repositories. The contractor shall receive no identifying or personal health information about the study subjects. A wide range of specimen types are collected including whole blood, cord blood, buffy coats, plasma, serum, urine, saliva, tissues (e.g., placenta, omental fat), hair, nail clippings, follicular and seminal fluid, semen, and newborn blood spots. DiPHR requires analysis of this diverse collection of specimen types for a multitude of factors, including concentrations of reproductive and other hormones; dietary biomarkers; cytokines; indicators of metabolic function including analysis of fatty acids, triglycerides, and glucose; immune function markers; low levels of C-reactive protein; as well as extraction of DNA for whole exome sequencing and methylation analysis; RNA isolation for use in expression arrays; and microbiome analysis. DiPHR requires analysis of collected biological specimens including blood (plasma, serum, WBC, etc.), urine, saliva, adipose tissue, follicular fluid, seminal fluid, and other biologic material relevant for specific research initiatives. Proposed analyses include measurement of concentrations of steroid hormones; measurement of heavy metals; measurement of antioxidants and other nutritional markers including carotenoids, tocopherols, leptin, and leptin receptor; measurement of immune system markers; the flexibility to measure different analytes using multiplex and ELISA techniques; and quantification of metabolomics, proteomics, and genome-wide association studies. DiPHR designs and conducts innovative etiologic and interventional research from preconception through adulthood, focusing on successful reproduction, the health and well-being of pregnant women and their infants, and the optimal growth and development of children and adolescents across the lifespan. To accomplish this, the Division generates a collection of de-identified human biospecimens pertaining to these research activities. The Division requires the services of a biomedical laboratory to provide validated, clinical analyses of biospecimens as well as to modify and/or develop new analysis as needed to measure these biological specimens.

人口健康研究部（DIPHR）对与人类繁殖和发展有关的各种主题，儿童和青少年的健康和行为以及对孕妇的照顾等各种主题进行了研究。观察性研究和介入研究研究均受DIPHR科学家的设计和实施，大多数研究都包括收集各种数据和生物测量。 所有生物测量均使用批准的方案收集，并在NICHD支持的存储库中进行银行业务之前进行取消识别。承包商不得获得有关研究对象的识别或个人健康信息。收集了广泛的标本类型，包括全血，脐带血，血浆，血浆，血清，尿液，唾液，组织（例如，胎盘，胶质脂肪），头发，头发，指甲剪报，卵泡和精液，精液，精液，精液和新生儿血液点。 DIPHR需要分析各种样品类型的收集，包括多种因素，包括生殖浓度和其他激素；饮食生物标志物；细胞因子；代谢功能的指标，包括分析脂肪酸，甘油三酸酯和葡萄糖；免疫功能标记；低水平的C反应蛋白；以及提取DNA进行整个外显子组测序和甲基化分析的提取； RNA隔离用于表达阵列；和微生物组分析。 DIPHR需要分析收集的生物标本，包括血液（血浆，血清，WBC等），尿液，唾液，脂肪组织，卵泡液，精确液和其他与特定研究计划相关的生物学材料。建议的分析包括测量类固醇激素的浓度；重金属的测量；测量包括类胡萝卜素，生育酚，瘦素和瘦素受体在内的抗氧化剂和其他营养标志物；免疫系统标记的测量；使用多路复用和ELISA技术测量不同分析物的灵活性；以及代谢组学，蛋白质组学和全基因组关联研究的定量。 DIPHR从成年到成年期设计并进行创新的病因学和介入研究，重点是成功的繁殖，孕妇及其婴儿的健康和福祉，以及整个生命周期的儿童和青少年的最佳成长和发展。为此，该部门产生了与这些研究活动有关的取消识别的人类生物测量的集合。该部门要求生物医学实验室的服务提供经过验证的生物测量的临床分析，并根据需要修改和/或开发新的分析来测量这些生物标本。