B WELL MOM FATTY ACID PROFILE

B WELL MOM 脂肪酸概况

• 批准号: 10349984
• 负责人: MICHAEL TSAI
• 金额: $ 1.11万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-25 至 2022-01-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10349984
• 关键词: Asthma; Blood specimen; Environment; Fatty Acids; First Pregnancy Trimester; Genetic; Life Style; Measures; Personal Satisfaction; Plasma; Postpartum Period; Pregnancy; Pregnancy Outcome; Pregnancy Trimesters; RNA; Risk Factors; Role; Serum; Specimen; Swab; Tissues; Umbilical Cord Blood; Urine; Visit; Woman; microbiome; nasal swab; pregnancy immunology; pulmonary function; recruit; social health determinants

The purpose of the Breathe – Wellbeing, Environment, Lifestyle and Lung Function Study (B-WELL Mom Study) is to examine the role of asthma control in pregnancy outcomes. This study examines poor asthma control in the context of the immunology of pregnancy and risk factors such as genetics, the environment, and social determinants of health. Women with and without asthma were recruited during the first trimester of pregnancy (< 15 weeks gestation) and followed through 4 months post-partum. Assessments occurred during each trimester of pregnancy (<15 weeks, 20-22 weeks, 30-32 weeks), at delivery, and 4 months post-partum. The B-WELL Mom study collected urine, microbiome swabs, and blood samples (PAXGene RNA, serum, plasma, and buffy coat) from approximately 400 subjects at each visit (<15 weeks, 20-22 weeks, 30-32 weeks) and 4 months post-partum. Nasal swabs were collected once during pregnancy, and placental tissue specimens and cord blood RNA were collected at delivery.

呼吸-健康，环境，生活方式和肺功能研究（B-WELL母亲研究）的目的是检查哮喘控制在妊娠结局中的作用。本研究在妊娠免疫学和遗传学、环境和健康的社会决定因素等风险因素的背景下探讨了哮喘控制不良。 在怀孕的前三个月（< 15周）招募患有哮喘和没有哮喘的妇女，并随访至产后4个月。评估发生在妊娠的每个三个月（<15周，20-22周，30-32周），分娩时和产后4个月。 B-WELL Mom研究在每次访视（<15周、20-22周、30-32周）和产后4个月时从约400名受试者收集尿液、微生物组拭子和血液样品（PAXGene RNA、血清、血浆和血沉棕黄层）。在妊娠期间采集一次鼻拭子，并在分娩时采集胎盘组织标本和脐带血RNA。