UPSTATE KIDS ANALYSIS

北部儿童分析

• 批准号: 10187717
• 负责人: MICHAEL TSAI
• 金额: $ 11.94万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10187717
• 关键词: Adrenal Glands; Age; Blood; Blood specimen; C-reactive protein; Cardiovascular Diseases; Cardiovascular system; Child; Cholesterol; Conceptions; DNA; Epigenetic Process; Erythrocytes; Follow-Up Studies; Glycosylated hemoglobin A; Health; High Density Lipoproteins; Lipids; Low-Density Lipoproteins; Measures; Mothers; Plasma; Puberty; Saliva; Sampling; Specimen; Triglycerides; Whole Blood; assisted reproduction; cardiovascular disorder risk; cardiovascular risk factor; dehydroepiandrosterone; epigenetic marker; infertility treatment; methylation pattern; treatment effect

The purpose of the Upstate KIDS Cardiovascular Disease (CVD) follow-up study is to determine if infertility treatment is associated with a risk of CVD or the timing of puberty. Studies have shown that some pubertal markers appear altered after IVF conception and early adrenarche may itself confer a risk of CVD. Epigenetics may be the mechanism underlying treatment effects. The Upstate KIDS study consisted of children conceived by infertility treatment and children conceived naturally. In this follow-up study, specimens including blood and saliva were taken from children between the ages of 6 and 8. Blood was also taken from mothers to assess confounding by maternal CVD risk.

上州儿童心血管疾病（CVD）的后续研究的目的是确定是否是否 不育治疗与CVD的风险或青春期时机有关。研究表明 在IVF概念和早期的Adrenarche本身之后，一些青春期标记似乎发生了变化 赋予CVD的风险。表观遗传学可能是治疗效果的机制。 北部儿童研究由不孕治疗和儿童构想的孩子组成 自然而然地构思。在这项后续研究中，从包括血液和唾液在内的标本中取自 6至8岁之间的儿童也从母亲那里吸收血液来评估混杂 母体CVD风险。