University of Michigan BACPAC Mechanistic Research Center

密歇根大学BACPAC机理研究中心

• 批准号: 10202826
• 负责人: Daniel J Clauw
• 金额: $ 7.11万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-26 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10202826
• 关键词: Area; Award; Back Pain; Characteristics; Chronic low back pain; Development; Environment; Evaluation; Individual; Intervention; Michigan; Modification; Pain Research; Participant; Patients; Pharmaceutical Preparations; Phenotype; Predictive Factor; Provider; Recording of previous events; Research; Review Literature; Training; Trauma; Treatment Efficacy; Universities; Work; chronic pain patient; clinical pain; cohort; effective intervention; experience; individualized medicine; interest; nondrug therapy; pain patient; parent grant; programs; response; theories; treatment planning

PROJECT SUMMARY/ABSTRACT The parent grant was awarded as a HEAL Initiative award, specifically as part of the Back Pain Consortium (BACPAC) Research Program (FOA: AR19-026). The current proposal will supplement the University of Michigan Mechanistic Research Center (UM MRC; U19 AR076734-01). The UM MRC aims to perform interventional response phenotyping in a cohort of chronic low back pain (cLBP) patients. Interventional response phenotyping describes the critical need to attain high quality information on each participant regarding to which drug and non-drug therapies they do and do not respond. This need extends to psychotherapeutic interventions, which are often used for the treatment of cLBP. This proposal will provide one year of support for the candidate to attain focused training in clinical pain research, including exploring differential response to psychotherapeutic interventions. Successful completion of this work will provide the HEAL Initiative with an extensive systematic literature review examining baseline phenotypic factors that predict differential responsiveness to the some of the most commonly used psychotherapeutic interventions for cLBP. The training plan will allow the candidate to: 1) understand the theory underlying and execution of some of the most commonly used psychotherapeutic interventions for cLBP; 2) develop expertise in phenotypic differences among patients with cLBP that might impact interventional efficacy; and 3) understand the patient and provider experience in order to promote the development and implementation of effective interventions for cLBP. The candidate will work with the PIs of the parent grant, Drs. Afton Hassett and Daniel Clauw, to complete this comprehensive training and research plan. Combined with the rich environment of the University of Michigan, this award will provide focused training to establish a unique niche of expertise and an independent research program focused on intervention modification, development, and evaluation for chronic pain patients with a history of trauma, the candidate’s primary area of interest.

项目摘要/摘要 家长奖助金是作为Heave Initiative奖授予的，特别是作为Back的一部分 疼痛联盟(BACPAC)研究计划(FOA：AR19-026)。目前的提案 将补充密歇根大学力学研究中心(UM MRC；U19 AR076734-01)。UM MRC的目标是在一个 慢性下腰痛(CLBP)患者队列。介入反应表型 描述获取有关以下方面的每个参与者的高质量信息的迫切需要 哪些药物和非药物治疗有效，哪些无效。这一需求扩展到 心理治疗干预，通常用于慢性下腰痛的治疗。这 建议书将为候选人提供一年的支持，以实现以下方面的重点培训 临床疼痛研究，包括探索心理治疗的不同反应 干预措施。这项工作的成功完成将为Hear倡议提供 广泛系统的文献综述，考察预测 对一些最常用的心理治疗药物的不同反应 慢性下腰痛的干预措施。培训计划将允许应聘者：1)了解 一些最常用的心理疗法的理论基础和实施 CLBP的干预措施；2)在慢性LBP患者中发展表型差异的专业知识 可能影响介入疗效的cLBP；以及3)了解患者和提供者 以经验促进发展和有效实施 慢性下腰痛的干预措施。候选人将与家长资助的PI一起工作，Afton博士 哈西特和丹尼尔·克劳夫，完成这一全面的培训和研究计划。 结合密歇根大学的丰富环境，该奖项将提供 集中培训，建立独特的专业技能和独立研究 专注于慢性疼痛的干预修改、开发和评估的计划 有创伤史的患者，这是应聘者主要感兴趣的领域。