University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
基本信息
- 批准号:9898106
- 负责人:
- 金额:$ 896.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-26 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:AcupressureAddressAlgorithmsAmericanBackBiological MarkersCaringChronic low back painClinicalCoinDataDiagnostic TrialDiagnostic testsDiseaseEconomic FactorsEnrollmentFacet joint structureFibromyalgiaFocus GroupsImageIndividualInflammationInjectionsInterventionKnowledgeLeadLeadershipLeftLightLinkMeasuresMichiganNational Institute of Diabetes and Digestive and Kidney DiseasesOnline SystemsOperative Surgical ProceduresOutcomePainPain ClinicsPain managementParticipantPatient Outcomes AssessmentsPatientsPelvisPharmaceutical PreparationsPhenotypePhysical ExaminationPhysical therapy exercisesPlacebo EffectPlasmaPositioning AttributePrecision Medicine InitiativeProceduresQuestionnairesRandomizedResearchResearch DesignResearch MethodologyResearch Project GrantsSelf AdministrationSensorySpinalSpine surgerySteroidsStructureSurveysSystems BiologyTestingTherapeuticTherapeutic InterventionTranslational ResearchUnited States National Institutes of HealthUniversitiesVisionWorkactigraphybasechronic pelvic paincohortdesignduloxetineendophenotypeevidence baseexperiencegabapentinindividual patientmembermindfulness based cognitive therapymindfulness-based stress reductionneuroimagingnon-opioid analgesicnondrug therapypain patientpersonalized medicinepragmatic trialprecision medicinepredicting responsepsychologicracial and ethnicrandomized trialresponseself-management programsocialtargeted treatmenttreatment durationtreatment responseworking group
项目摘要
PROJECT SUMMARY / ABSTRACT
OVERALL COMPONENT
The NIH BACPAC initiative is designed to “generate new knowledge regarding phenotypes, endotypes,
mechanisms, diagnostics, trial outcomes, and therapeutic responsiveness . . . in chronic low back pain (cLBP).
We feel that our group at the University of Michigan (UM) is ideally suited to lead a Mechanistic Research
Center (MRC) as part of the broader BACPAC initiative, because we have been working along all of these lines
for over twenty years. We propose a single Research Project that will take patients with cLBP and use a
patient-centric, SMART design study to follow these individuals longitudinally as they try several different
evidence-based therapies, while mechanistic studies are overlaid to draw crucial inferences about what
treatments will work in what patient endotypes. We use the term Interventional Response Phenotyping to
describe the need in any precision medicine initiative to phenotype participants regarding what therapies they
do and do not respond to - so that one can later link mechanistically distinct disease endophenotypes with
those who preferentially respond to therapies targeting those mechanisms. The first Specific Aim of the UM
BACPAC MRC is to perform Interventional Response Phenotyping in a cohort of cLBP patients (n=500). We
will perform a long-term pragmatic trial using a well-established cohort of cLBP patients, who will receive a
sequence of interventions known to be effective in cLBP. All cLBP participants will for the first 6 weeks receive
a web-based patient self-management program for pain. This first treatment period is not testing mechanistic
hypotheses, but instead will reduce or eliminate regression to the mean, as well as the placebo effect of
interacting with staff, prior to subsequent randomized treatments. Then participants who remain symptomatic
will be enrolled in an adaptive, Sequential Multiple Assessment Randomized Trial (SMART) to randomize
individuals to two additional treatments given for 12 weeks each, from a list including: a) mindfulness-based
cognitive therapy (MBCT); b) physical therapy and exercise; c) duloxetine, d) gabapentin and e) self-
administered acupressure. At any point during the study, participants (as part of ongoing care) may also
undergo an epidural steroid or facet joint injection, or lumbar surgery. Although participants will not be
randomized to receive these interventional therapies, we can assess for predictors of differential
responsiveness. The second Specific Aim of this proposal is to demonstrate that currently available, clinically-
derived measures, can predict differential responsiveness to the above therapies (n=500). The third Specific
Aim is to identify new experimental measures (functional neuroimaging, quantitative sensory testing, plasma
measures of inflammation, autonomic tone) that predict differential responsiveness to the each of the
therapies, as well as to infer mechanisms of action of treatments (n=200). The fourth Specific Aim is to
contribute to the broader BACPAC initiative by providing data on our MRC participants, as well as contributing
scientific expertise, research methods, and leadership to BACPAC.
项目摘要/摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Daniel J Clauw其他文献
Therapy Insight: fibromyalgia—a different type of pain needing a different type of treatment
治疗见解:纤维肌痛——一种需要不同类型治疗的不同类型疼痛
- DOI:
10.1038/ncprheum0221 - 发表时间:
2006-07-01 - 期刊:
- 影响因子:32.700
- 作者:
Dina Dadabhoy;Daniel J Clauw - 通讯作者:
Daniel J Clauw
Confocal microscopy reveals nerve fiber similarities in fibromyalgia and patients with dry eyes with a normal ophthalmic exam
- DOI:
10.1186/1744-8069-10-s1-p2 - 发表时间:
2014-12-15 - 期刊:
- 影响因子:2.800
- 作者:
Daniel E Harper;Vincent Pallazola;David A Williams;Steven Harte;Daniel J Clauw;Roni M Shtein - 通讯作者:
Roni M Shtein
Recommendations for Improving Systemic Lupus Erythematosus Care From Black Adults
改善黑人成人系统性红斑狼疮护理的建议
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:13.8
- 作者:
Bhaavna Yalavarthi;Johari Summerville;Nikki Farahani;Lillian Z. Xiao;Christine Yu;Deena Aboul;Sia Rajgarhia;Daniel J Clauw;J. M. Kahlenberg;Melissa DeJonckheere;Rachel S. Bergmans - 通讯作者:
Rachel S. Bergmans
Chronic overlapping pain conditions increase the risk of long COVID features, regardless of acute COVID status
无论急性新冠肺炎状态如何,慢性重叠疼痛都会增加长期新冠特征的风险
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:7.4
- 作者:
Rachel S. Bergmans;Daniel J Clauw;Candace Flint;Herb Harris;Seth Lederman;A. Schrepf - 通讯作者:
A. Schrepf
230 - Long-Term Efficacy of Digital Acceptance and Commitment Therapy for Fibromyalgia: Follow-Up of the PROSPER-FM Trial At 12 Months
230 - 数字接纳与承诺疗法对纤维肌痛的长期疗效:PROSPER-FM 试验 12 个月随访
- DOI:
10.1016/j.jpain.2025.105028 - 发表时间:
2025-04-01 - 期刊:
- 影响因子:4.000
- 作者:
Michael J Rosenbluth;Dianne Shumay;Yifei Dai;R Michael Gendreau;Nicolette Vega;Lance M McCracken;David A Williams;Juan V Luciano;Andrea L Chadwick;Daniel J Clauw;Brian Keefe;Lesley M Arnold - 通讯作者:
Lesley M Arnold
Daniel J Clauw的其他文献
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{{ truncateString('Daniel J Clauw', 18)}}的其他基金
University of Michigan (UM) HEAL Initiative National K12 Clinical Pain Career Development Program (UM-HCPDP)
密歇根大学 (UM) HEAL Initiative 国家 K12 临床疼痛职业发展计划 (UM-HCPDP)
- 批准号:
10884563 - 财政年份:2023
- 资助金额:
$ 896.94万 - 项目类别:
University of Michigan (UM) HEAL Initiative National K12 Clinical Pain Career Development Program (UM-HCPDP)
密歇根大学 (UM) HEAL Initiative 国家 K12 临床疼痛职业发展计划 (UM-HCPDP)
- 批准号:
10596851 - 财政年份:2022
- 资助金额:
$ 896.94万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10415416 - 财政年份:2021
- 资助金额:
$ 896.94万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10395664 - 财政年份:2021
- 资助金额:
$ 896.94万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10398444 - 财政年份:2019
- 资助金额:
$ 896.94万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10202826 - 财政年份:2019
- 资助金额:
$ 896.94万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10765807 - 财政年份:2019
- 资助金额:
$ 896.94万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10650650 - 财政年份:2019
- 资助金额:
$ 896.94万 - 项目类别:
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