University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
基本信息
- 批准号:10650650
- 负责人:
- 金额:$ 11.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-26 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AcupressureAddressAnalgesicsAutoimmune DiseasesAwardChronic low back painClinicalDataEffectivenessEvaluationFunctional ImagingFunctional Magnetic Resonance ImagingGoalsHelping to End Addiction Long-termIndividualInflammationInterventionKnowledgeLearning SkillMeasuresMethodsMichiganModalityNeurobiologyOnline SystemsPainPain MeasurementParentsPatient Outcomes AssessmentsPatientsPharmacologyPhenotypePhysical therapyPlasmaPredictive FactorQuality of lifeRandomizedReportingResearchRheumatismSelf CareSensorySeriesStandardizationTestingTrainingTreatment EffectivenessUniversitiesWorkbasechronic paincohortdebilitating paindigitaldigital interventiondisabilityduloxetineefficacious treatmentefficacy evaluationevidence baseexperiencefunctional disabilitygabapentinmindfulness interventionpain patientparent grantprecision medicinepredicting responseresponserheumatologistself-management programtreatment effecttreatment response
项目摘要
Project Summary / Abstract
Individual and societal burdens from chronic low back pain (cLBP) are significant and associated with long
term functional impairment, disability, and poor quality of life. There are many efficacious treatments in cLBP
but the factors that predict treatment effectiveness in an individual are still not well understood. Treatments for
chronic pain include several pharmacologic (e.g., duloxetine and gabapentin) and non-pharmacologic
treatments such as physical therapy, acupressure, mindfulness-based interventions, and web-based self-
management programs. There is an urgent need for a greater understanding of pain mechanisms and
predictors of response to different therapies with a goal of matching patients based on phenotypes to therapies
to which they are most likely to respond. The parent award, a HEAL Initiative award (U19 AR076734), uses a
precision medicine approach to identify what treatments are likely to work in different patient endotypes. The
proposed supplement will allow me, a clinical rheumatologist, to learn these skills through assessments of
acupressure and the web-based self-management program on patient-reported pain in cLBP. Clinically
available data (such as patient-reported outcomes) as well as state-of-the-art phenotyping methods such as
functional MRI (fMRI) and Quantitative Sensory Testing (QST), will be available to mechanistically explore the
proposed neurobiological effects of these treatments. This knowledge will be invaluable in my future research
on evaluation of pain mechanisms and responsiveness to treatment based on phenotypes of individuals with
rheumatic disease.
项目总结/摘要
慢性下腰痛(cLBP)的个人和社会负担是显著的,并且与长期
长期功能障碍、残疾和生活质量差。慢性腰痛有多种有效的治疗方法
但是预测个体治疗效果的因素仍然没有很好的理解。治疗
慢性疼痛包括几种药理学(例如,度洛西汀和加巴喷丁)和非药物
治疗,如物理疗法,穴位按摩,正念为基础的干预,和基于网络的自我,
管理方案。迫切需要更好地了解疼痛机制,
预测对不同疗法的反应,目标是根据表型匹配患者与疗法
他们最有可能做出回应。母公司奖,一个愈合倡议奖(U19 AR 076734),使用一个
精确医学方法,以确定哪些治疗可能适用于不同的患者内型。的
建议的补充将使我,一个临床风湿病学家,通过评估这些技能,
穴位按摩和基于网络的自我管理计划对cLBP患者报告的疼痛。临床
现有数据(如患者报告的结局)以及最先进的表型分析方法,
功能性磁共振成像(fMRI)和定量感觉测试(QST),将可用于机械地探索
这些治疗的神经生物学效应。这些知识对我今后的研究将是无价的
基于个体的表型评价疼痛机制和对治疗的反应性,
风湿病
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Daniel J Clauw其他文献
Therapy Insight: fibromyalgia—a different type of pain needing a different type of treatment
治疗见解:纤维肌痛——一种需要不同类型治疗的不同类型疼痛
- DOI:
10.1038/ncprheum0221 - 发表时间:
2006-07-01 - 期刊:
- 影响因子:32.700
- 作者:
Dina Dadabhoy;Daniel J Clauw - 通讯作者:
Daniel J Clauw
Confocal microscopy reveals nerve fiber similarities in fibromyalgia and patients with dry eyes with a normal ophthalmic exam
- DOI:
10.1186/1744-8069-10-s1-p2 - 发表时间:
2014-12-15 - 期刊:
- 影响因子:2.800
- 作者:
Daniel E Harper;Vincent Pallazola;David A Williams;Steven Harte;Daniel J Clauw;Roni M Shtein - 通讯作者:
Roni M Shtein
Recommendations for Improving Systemic Lupus Erythematosus Care From Black Adults
改善黑人成人系统性红斑狼疮护理的建议
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:13.8
- 作者:
Bhaavna Yalavarthi;Johari Summerville;Nikki Farahani;Lillian Z. Xiao;Christine Yu;Deena Aboul;Sia Rajgarhia;Daniel J Clauw;J. M. Kahlenberg;Melissa DeJonckheere;Rachel S. Bergmans - 通讯作者:
Rachel S. Bergmans
Chronic overlapping pain conditions increase the risk of long COVID features, regardless of acute COVID status
无论急性新冠肺炎状态如何,慢性重叠疼痛都会增加长期新冠特征的风险
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:7.4
- 作者:
Rachel S. Bergmans;Daniel J Clauw;Candace Flint;Herb Harris;Seth Lederman;A. Schrepf - 通讯作者:
A. Schrepf
From fibrositis to fibromyalgia to nociplastic pain: how rheumatology helped get us here and where do we go from here?
从纤维织炎到纤维肌痛再到伤害性感受性疼痛:风湿病学如何引领我们走到这一步,以及我们今后该何去何从?
- DOI:
10.1136/ard-2023-225327 - 发表时间:
2024-11-01 - 期刊:
- 影响因子:20.600
- 作者:
Daniel J Clauw - 通讯作者:
Daniel J Clauw
Daniel J Clauw的其他文献
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{{ truncateString('Daniel J Clauw', 18)}}的其他基金
University of Michigan (UM) HEAL Initiative National K12 Clinical Pain Career Development Program (UM-HCPDP)
密歇根大学 (UM) HEAL Initiative 国家 K12 临床疼痛职业发展计划 (UM-HCPDP)
- 批准号:
10884563 - 财政年份:2023
- 资助金额:
$ 11.28万 - 项目类别:
University of Michigan (UM) HEAL Initiative National K12 Clinical Pain Career Development Program (UM-HCPDP)
密歇根大学 (UM) HEAL Initiative 国家 K12 临床疼痛职业发展计划 (UM-HCPDP)
- 批准号:
10596851 - 财政年份:2022
- 资助金额:
$ 11.28万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10415416 - 财政年份:2021
- 资助金额:
$ 11.28万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10395664 - 财政年份:2021
- 资助金额:
$ 11.28万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10398444 - 财政年份:2019
- 资助金额:
$ 11.28万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10202826 - 财政年份:2019
- 资助金额:
$ 11.28万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
9898106 - 财政年份:2019
- 资助金额:
$ 11.28万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10765807 - 财政年份:2019
- 资助金额:
$ 11.28万 - 项目类别:
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