University of Michigan BACPAC Mechanistic Research Center

项目摘要/摘要 增加临床疼痛研究参与者的种族/民族多样性，并将利益相关者纳入 设计和进行研究是相互交织的目标，对于提高可接受性至关重要， 疼痛研究的可行性、严谨性和相关性。这项拟议的对母公司的行政补充 密歇根大学(UM)的BACPAC力学研究中心将支持一项强有力的努力 加强耐心和其他利益攸关方的参与，特别是代表人数不足的少数群体的参与，并 对历史上服务不足的黑人和西班牙裔社区实施持续的外展努力 在底特律和密歇根州弗林特附近。母研究项目的目标是进行连续的、多次的 任务，随机试验(SMART)，调查慢性腰背患者的行为和医学干预 并进行干预反应表型分析。Bacpac MRC位于UM慢性疼痛中心 和疲劳研究中心(CPFRC)，这是一个成功的翻译研究小组，专注于识别 治疗慢性疼痛的潜在机制和最有效的治疗方法。补充目标1是 聘请两名全职社区研究促进员(CRF)，他们将在底特律和弗林特进行外展 区域。CRF将是社区卫生工作者或具有类似经验的个人；也就是说，他们将 对当地资源有深入的了解，可以作为研究和多样化的桥梁 社区。CRF将在底特律以黑人和西班牙裔为主的社区领导外展工作 和弗林特地区支持研究人员招募工作并增加样本多样性；将促进双向 CPFRC与社区利益攸关方之间的沟通和知识传播；并将有助于 登记的参与者克服了参与临床试验的挑战，从而提高了保留率。 补充目标2是建立一个慢性疼痛临床研究利益相关者咨询委员会(StACC) 这将包括生活在痛苦中的人，他们在种族/民族、年龄、性别和城乡方面都是不同的。 地点；以及包括提供者、临床医生和疼痛研究人员在内的其他利益攸关方。这群人将会是 使用利益相关者参与的最佳实践进行治理，并将包括对患者顾问的正式培训 在研究基础方面，以及在社区参与研究方面对学者进行培训。StACC将提供 对招聘、数据收集、分析和解释等问题提供有意义的意见，以确保 BACAC MRC研究最大限度地允许不同的参与者访问，并且收集的数据是有效的 切合实际。我们将对科技咨询委员会的进程和成果进行全面评估。完成 这些目标将为CPFRC内的可持续基础设施奠定基础，以加强伙伴关系 与服务不足的有色人种社区建立持久、信任的关系。这一基础设施将 促进从不同患者那里获得新研究的意见，因为他们正在计划中，招募更多不同的人 我们正在进行的研究，并将我们的研究结果传达给这些群体。

Project Summary/Abstract Increasing the racial/ethnic diversity of participants in clinical pain research and including stakeholders in the design and conduct of research are intertwined goals that are essential to increasing the acceptability, feasibility, rigor, and relevance of pain research. This proposed administrative supplement to the parent BACPAC Mechanistic Research Center at the University of Michigan (UM) will support a robust effort to enhance patient and other stakeholder engagement, particularly that of underrepresented minorities, and to implement a sustained outreach effort to the historically underserved Black and Hispanic communities in and around Detroit and Flint, Michigan. The goal of the parent research project is to conduct a sequential, multiple assignment, randomized trial (SMART) to investigate behavioral and medical interventions in chronic low back pain, and to conduct intervention response phenotyping. The BACPAC MRC is housed at the UM Chronic Pain and Fatigue Research Center (CPFRC), a successful translational research group focused on identifying the underlying mechanisms and most effective treatments for individuals with chronic pain. Supplement Aim 1 is to hire two full-time Community Research Facilitators (CRFs) who will conduct outreach in the Detroit and Flint areas. The CRFs will be community health workers or individuals with similar experience; that is, they will possess deep knowledge of local resources and can serve as a bridge between research and diverse communities. CRFs will lead outreach efforts in predominantly Black and Hispanic communities in the Detroit and Flint areas to support study recruitment efforts and increase sample diversity; will facilitate bidirectional communication and knowledge transmission between the CPFRC and community stakeholders; and will help enrolled participants navigate the challenges of participating in clinical trials, thereby enhancing retention. Supplement Aim 2 is to establish a Stakeholder Advisory Board for Clinical Research in Chronic Pain (StACC) that will include people living with pain who are diverse in terms of race/ethnicity, age, gender, and rural/urban location; as well as other stakeholders including providers, clinicians, and pain researchers. This group will be governed using best practices for stakeholder engagement and will include formal training of patient advisors in research fundamentals, and training of academics in community-engaged research. The StACC will provide meaningful input on issues such as recruitment, data collection, analysis, and interpretation to ensure that the BACPAC MRC research is maximally accessible to diverse participants and that data collected is valid and relevant. We will conduct a comprehensive evaluation of the StACC process and outcomes. Completion of these Aims will lay the foundation for a sustainable infrastructure within the CPFRC to enhance partnerships with underserved communities of color and form long-lasting, trusting relationships. This infrastructure will facilitate getting input from diverse patients for new studies as they are being planned, recruiting more diverse populations into our ongoing studies, and communicating our findings to these groups.