University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
基本信息
- 批准号:10398444
- 负责人:
- 金额:$ 58.35万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-26 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdministrative SupplementAfrican AmericanAreaBehavioralBusinessesCase StudyChronic low back painClinical ResearchClinical TrialsColorCommunicationCommunitiesCommunity Health AidesDataData CollectionDisadvantagedDiscriminationEducationEducation and OutreachEnrollmentEnsureEthnic OriginEvaluationExtramural ActivitiesFailureFatigueFocus GroupsFoundationsFundingGenderGoalsGrantHealthcare SystemsHispanicsHospitalsIndividualInfrastructureInstitutional RacismInsuranceInterventionKnowledgeLeadLocationMedicalMedical ResearchMedicineMichiganModelingOutcomePainPain ResearchParentsParticipantPatient EducationPatientsPhasePhenotypePopulationPopulation HeterogeneityPractice based researchPrivatizationProcessProviderRaceRecruitment ActivityResearchResearch InfrastructureResearch PersonnelResearch Project GrantsResourcesRuralSamplingSampling StudiesSequential Multiple Assignment Randomized TrialSiteStructureTimeTrainingTranslational ResearchTrustUnderrepresented MinorityUnited States National Institutes of HealthUniversitiesVulnerable PopulationsWorkWritingchronic painclinical paincohortcommunity based participatory researchcommunity based researchcommunity cliniccommunity engaged researchcommunity organizationscostdesigneffective therapyethnic diversityexperiencefundamental researchhealth disparityimprovedoutreachracial and ethnicrecruitresponsesystems researchtransmission processunderserved communityurban areawillingness
项目摘要
Project Summary/Abstract
Increasing the racial/ethnic diversity of participants in clinical pain research and including stakeholders in the
design and conduct of research are intertwined goals that are essential to increasing the acceptability,
feasibility, rigor, and relevance of pain research. This proposed administrative supplement to the parent
BACPAC Mechanistic Research Center at the University of Michigan (UM) will support a robust effort to
enhance patient and other stakeholder engagement, particularly that of underrepresented minorities, and to
implement a sustained outreach effort to the historically underserved Black and Hispanic communities in and
around Detroit and Flint, Michigan. The goal of the parent research project is to conduct a sequential, multiple
assignment, randomized trial (SMART) to investigate behavioral and medical interventions in chronic low back
pain, and to conduct intervention response phenotyping. The BACPAC MRC is housed at the UM Chronic Pain
and Fatigue Research Center (CPFRC), a successful translational research group focused on identifying the
underlying mechanisms and most effective treatments for individuals with chronic pain. Supplement Aim 1 is to
hire two full-time Community Research Facilitators (CRFs) who will conduct outreach in the Detroit and Flint
areas. The CRFs will be community health workers or individuals with similar experience; that is, they will
possess deep knowledge of local resources and can serve as a bridge between research and diverse
communities. CRFs will lead outreach efforts in predominantly Black and Hispanic communities in the Detroit
and Flint areas to support study recruitment efforts and increase sample diversity; will facilitate bidirectional
communication and knowledge transmission between the CPFRC and community stakeholders; and will help
enrolled participants navigate the challenges of participating in clinical trials, thereby enhancing retention.
Supplement Aim 2 is to establish a Stakeholder Advisory Board for Clinical Research in Chronic Pain (StACC)
that will include people living with pain who are diverse in terms of race/ethnicity, age, gender, and rural/urban
location; as well as other stakeholders including providers, clinicians, and pain researchers. This group will be
governed using best practices for stakeholder engagement and will include formal training of patient advisors
in research fundamentals, and training of academics in community-engaged research. The StACC will provide
meaningful input on issues such as recruitment, data collection, analysis, and interpretation to ensure that the
BACPAC MRC research is maximally accessible to diverse participants and that data collected is valid and
relevant. We will conduct a comprehensive evaluation of the StACC process and outcomes. Completion of
these Aims will lay the foundation for a sustainable infrastructure within the CPFRC to enhance partnerships
with underserved communities of color and form long-lasting, trusting relationships. This infrastructure will
facilitate getting input from diverse patients for new studies as they are being planned, recruiting more diverse
populations into our ongoing studies, and communicating our findings to these groups.
项目总结/摘要
增加临床疼痛研究参与者的种族/民族多样性,
研究的设计和实施是相互交织的目标,对提高可接受性至关重要,
疼痛研究的可行性、严谨性和相关性。这一建议的行政补充,以家长
密歇根大学(UM)的BACPAC机械研究中心将支持一项强有力的努力,
加强患者和其他利益相关者的参与,特别是代表性不足的少数群体,
对历史上服务不足的黑人和西班牙裔社区开展持续的外联工作,
底特律和密歇根州弗林特附近家长研究项目的目标是进行一个连续的,多个
一项研究慢性下腰痛患者行为和药物干预的随机分配试验(SMART)
疼痛,并进行干预反应表型。BACPAC MRC位于UM慢性疼痛
和疲劳研究中心(CPFRC),一个成功的翻译研究小组,专注于确定
慢性疼痛的潜在机制和最有效的治疗方法。补充目标1是
聘请两名全职社区研究促进者(CRF),他们将在底特律和弗林特进行外展
地区CRF将由社区卫生工作者或具有类似经验的个人担任;也就是说,
对当地资源有深入的了解,可以作为研究和多样化之间的桥梁。
社区. CRF将在底特律主要的黑人和西班牙裔社区领导外展工作
和弗林特地区,以支持研究招募工作和增加样本多样性;将促进双向
CPFRC与社区利益相关者之间的沟通和知识传递;并将有助于
登记的参与者应对参与临床试验的挑战,从而提高保留率。
补充目标2是建立慢性疼痛临床研究利益相关者咨询委员会(StACC)
这将包括在种族/民族、年龄、性别和农村/城市方面不同的患有疼痛的人。
地点;以及其他利益相关者,包括提供者,临床医生和疼痛研究人员。这一组将是
使用利益相关者参与的最佳实践进行管理,并将包括对患者顾问的正式培训
在研究基础方面,以及在社区参与的研究中培训学者。StACC将提供
在招聘、数据收集、分析和解释等问题上提供有意义的投入,以确保
BACPAC MRC研究是最大限度地访问不同的参与者,收集的数据是有效的,
相关的我们将对StACC的进程和成果进行全面评估。完成
这些目标将为CPFRC内部的可持续基础设施奠定基础,以加强伙伴关系
与未得到充分服务的有色人种社区建立长期的信任关系。这种基础设施将
在计划新研究时,促进从不同患者那里获得输入,招募更多不同的患者
我们正在进行的研究,并将我们的发现传达给这些群体。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Daniel J Clauw其他文献
Therapy Insight: fibromyalgia—a different type of pain needing a different type of treatment
治疗见解:纤维肌痛——一种需要不同类型治疗的不同类型疼痛
- DOI:
10.1038/ncprheum0221 - 发表时间:
2006-07-01 - 期刊:
- 影响因子:32.700
- 作者:
Dina Dadabhoy;Daniel J Clauw - 通讯作者:
Daniel J Clauw
Confocal microscopy reveals nerve fiber similarities in fibromyalgia and patients with dry eyes with a normal ophthalmic exam
- DOI:
10.1186/1744-8069-10-s1-p2 - 发表时间:
2014-12-15 - 期刊:
- 影响因子:2.800
- 作者:
Daniel E Harper;Vincent Pallazola;David A Williams;Steven Harte;Daniel J Clauw;Roni M Shtein - 通讯作者:
Roni M Shtein
Recommendations for Improving Systemic Lupus Erythematosus Care From Black Adults
改善黑人成人系统性红斑狼疮护理的建议
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:13.8
- 作者:
Bhaavna Yalavarthi;Johari Summerville;Nikki Farahani;Lillian Z. Xiao;Christine Yu;Deena Aboul;Sia Rajgarhia;Daniel J Clauw;J. M. Kahlenberg;Melissa DeJonckheere;Rachel S. Bergmans - 通讯作者:
Rachel S. Bergmans
Chronic overlapping pain conditions increase the risk of long COVID features, regardless of acute COVID status
无论急性新冠肺炎状态如何,慢性重叠疼痛都会增加长期新冠特征的风险
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:7.4
- 作者:
Rachel S. Bergmans;Daniel J Clauw;Candace Flint;Herb Harris;Seth Lederman;A. Schrepf - 通讯作者:
A. Schrepf
230 - Long-Term Efficacy of Digital Acceptance and Commitment Therapy for Fibromyalgia: Follow-Up of the PROSPER-FM Trial At 12 Months
230 - 数字接纳与承诺疗法对纤维肌痛的长期疗效:PROSPER-FM 试验 12 个月随访
- DOI:
10.1016/j.jpain.2025.105028 - 发表时间:
2025-04-01 - 期刊:
- 影响因子:4.000
- 作者:
Michael J Rosenbluth;Dianne Shumay;Yifei Dai;R Michael Gendreau;Nicolette Vega;Lance M McCracken;David A Williams;Juan V Luciano;Andrea L Chadwick;Daniel J Clauw;Brian Keefe;Lesley M Arnold - 通讯作者:
Lesley M Arnold
Daniel J Clauw的其他文献
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{{ truncateString('Daniel J Clauw', 18)}}的其他基金
University of Michigan (UM) HEAL Initiative National K12 Clinical Pain Career Development Program (UM-HCPDP)
密歇根大学 (UM) HEAL Initiative 国家 K12 临床疼痛职业发展计划 (UM-HCPDP)
- 批准号:
10884563 - 财政年份:2023
- 资助金额:
$ 58.35万 - 项目类别:
University of Michigan (UM) HEAL Initiative National K12 Clinical Pain Career Development Program (UM-HCPDP)
密歇根大学 (UM) HEAL Initiative 国家 K12 临床疼痛职业发展计划 (UM-HCPDP)
- 批准号:
10596851 - 财政年份:2022
- 资助金额:
$ 58.35万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10415416 - 财政年份:2021
- 资助金额:
$ 58.35万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10395664 - 财政年份:2021
- 资助金额:
$ 58.35万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10202826 - 财政年份:2019
- 资助金额:
$ 58.35万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
9898106 - 财政年份:2019
- 资助金额:
$ 58.35万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10765807 - 财政年份:2019
- 资助金额:
$ 58.35万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10650650 - 财政年份:2019
- 资助金额:
$ 58.35万 - 项目类别:
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