University of Michigan BACPAC Mechanistic Research Center

密歇根大学BACPAC机理研究中心

基本信息

  • 批准号:
    10398444
  • 负责人:
  • 金额:
    $ 58.35万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-26 至 2024-05-31
  • 项目状态:
    已结题

项目摘要

Project Summary/Abstract Increasing the racial/ethnic diversity of participants in clinical pain research and including stakeholders in the design and conduct of research are intertwined goals that are essential to increasing the acceptability, feasibility, rigor, and relevance of pain research. This proposed administrative supplement to the parent BACPAC Mechanistic Research Center at the University of Michigan (UM) will support a robust effort to enhance patient and other stakeholder engagement, particularly that of underrepresented minorities, and to implement a sustained outreach effort to the historically underserved Black and Hispanic communities in and around Detroit and Flint, Michigan. The goal of the parent research project is to conduct a sequential, multiple assignment, randomized trial (SMART) to investigate behavioral and medical interventions in chronic low back pain, and to conduct intervention response phenotyping. The BACPAC MRC is housed at the UM Chronic Pain and Fatigue Research Center (CPFRC), a successful translational research group focused on identifying the underlying mechanisms and most effective treatments for individuals with chronic pain. Supplement Aim 1 is to hire two full-time Community Research Facilitators (CRFs) who will conduct outreach in the Detroit and Flint areas. The CRFs will be community health workers or individuals with similar experience; that is, they will possess deep knowledge of local resources and can serve as a bridge between research and diverse communities. CRFs will lead outreach efforts in predominantly Black and Hispanic communities in the Detroit and Flint areas to support study recruitment efforts and increase sample diversity; will facilitate bidirectional communication and knowledge transmission between the CPFRC and community stakeholders; and will help enrolled participants navigate the challenges of participating in clinical trials, thereby enhancing retention. Supplement Aim 2 is to establish a Stakeholder Advisory Board for Clinical Research in Chronic Pain (StACC) that will include people living with pain who are diverse in terms of race/ethnicity, age, gender, and rural/urban location; as well as other stakeholders including providers, clinicians, and pain researchers. This group will be governed using best practices for stakeholder engagement and will include formal training of patient advisors in research fundamentals, and training of academics in community-engaged research. The StACC will provide meaningful input on issues such as recruitment, data collection, analysis, and interpretation to ensure that the BACPAC MRC research is maximally accessible to diverse participants and that data collected is valid and relevant. We will conduct a comprehensive evaluation of the StACC process and outcomes. Completion of these Aims will lay the foundation for a sustainable infrastructure within the CPFRC to enhance partnerships with underserved communities of color and form long-lasting, trusting relationships. This infrastructure will facilitate getting input from diverse patients for new studies as they are being planned, recruiting more diverse populations into our ongoing studies, and communicating our findings to these groups.
项目概要/摘要 增加临床疼痛研究参与者的种族/民族多样性,并将利益相关者纳入其中 研究的设计和实施是相互交织的目标,对于提高可接受性至关重要, 疼痛研究的可行性、严谨性和相关性。本建议向家长提供行政补充 密歇根大学 (UM) 的 BACPAC 机械研究中心将大力支持 加强患者和其他利益相关者的参与,特别是代表性不足的少数群体的参与,并 对历史上服务不足的黑人和西班牙裔社区实施持续的外展工作 密歇根州底特律和弗林特附近。母研究项目的目标是进行连续的、多重的 分配、随机试验 (SMART) 调查慢性腰背的行为和医疗干预措施 疼痛,并进行干预反应表型分析。 BACPAC MRC 位于 UM 慢性疼痛中心 和疲劳研究中心(CPFRC),一个成功的转化研究小组,专注于识别 慢性疼痛患者的潜在机制和最有效的治疗方法。补充目标 1 是 聘请两名全职社区研究协调员 (CRF),他们将在底特律和弗林特开展外展活动 地区。 CRF 将是社区卫生工作者或具有类似经验的个人;也就是说,他们会 对当地资源有深入的了解,可以充当研究和多样化之间的桥梁 社区。 CRF 将领导底特律以黑人和西班牙裔为主的社区的外展工作 和弗林特地区支持研究招募工作并增加样本多样性;将促进双向 CPFRC 与社区利益相关者之间的沟通和知识传播;并将帮助 登记的参与者应对参与临床试验的挑战,从而提高保留率。 补充目标 2 是建立慢性疼痛临床研究利益相关者咨询委员会 (StACC) 这将包括在种族/民族、年龄、性别和农村/城市方面各不相同的痛苦患者 地点;以及其他利益相关者,包括提供者、临床医生和疼痛研究人员。这组将是 使用利益相关者参与的最佳实践进行管理,并将包括对患者顾问的正式培训 研究基础知识以及社区参与研究的学者培训。 StACC 将提供 对招聘、数据收集、分析和解释等问题提供有意义的投入,以确保 BACPAC MRC 研究最大限度地可供不同参与者使用,并且收集的数据有效且 相关的。我们将对 StACC 的进程和结果进行全面评估。完成 这些目标将为 CPFRC 内的可持续基础设施奠定基础,以加强伙伴关系 与服务不足的有色人种社区建立持久、信任的关系。该基础设施将 促进不同患者对正在计划的新研究的投入,招募更多不同的人 人群参与我们正在进行的研究,并将我们的研究结果传达给这些群体。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Daniel J Clauw其他文献

Therapy Insight: fibromyalgia—a different type of pain needing a different type of treatment
治疗见解:纤维肌痛——一种需要不同类型治疗的不同类型疼痛
  • DOI:
    10.1038/ncprheum0221
  • 发表时间:
    2006-07-01
  • 期刊:
  • 影响因子:
    32.700
  • 作者:
    Dina Dadabhoy;Daniel J Clauw
  • 通讯作者:
    Daniel J Clauw
Confocal microscopy reveals nerve fiber similarities in fibromyalgia and patients with dry eyes with a normal ophthalmic exam
  • DOI:
    10.1186/1744-8069-10-s1-p2
  • 发表时间:
    2014-12-15
  • 期刊:
  • 影响因子:
    2.800
  • 作者:
    Daniel E Harper;Vincent Pallazola;David A Williams;Steven Harte;Daniel J Clauw;Roni M Shtein
  • 通讯作者:
    Roni M Shtein
Recommendations for Improving Systemic Lupus Erythematosus Care From Black Adults
改善黑人成人系统性红斑狼疮护理的建议
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    13.8
  • 作者:
    Bhaavna Yalavarthi;Johari Summerville;Nikki Farahani;Lillian Z. Xiao;Christine Yu;Deena Aboul;Sia Rajgarhia;Daniel J Clauw;J. M. Kahlenberg;Melissa DeJonckheere;Rachel S. Bergmans
  • 通讯作者:
    Rachel S. Bergmans
Chronic overlapping pain conditions increase the risk of long COVID features, regardless of acute COVID status
无论急性新冠肺炎状态如何,慢性重叠疼痛都会增加长期新冠特征的风险
  • DOI:
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    7.4
  • 作者:
    Rachel S. Bergmans;Daniel J Clauw;Candace Flint;Herb Harris;Seth Lederman;A. Schrepf
  • 通讯作者:
    A. Schrepf
From fibrositis to fibromyalgia to nociplastic pain: how rheumatology helped get us here and where do we go from here?
从纤维织炎到纤维肌痛再到伤害性感受性疼痛:风湿病学如何引领我们走到这一步,以及我们今后该何去何从?
  • DOI:
    10.1136/ard-2023-225327
  • 发表时间:
    2024-11-01
  • 期刊:
  • 影响因子:
    20.600
  • 作者:
    Daniel J Clauw
  • 通讯作者:
    Daniel J Clauw

Daniel J Clauw的其他文献

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{{ truncateString('Daniel J Clauw', 18)}}的其他基金

University of Michigan (UM) HEAL Initiative National K12 Clinical Pain Career Development Program (UM-HCPDP)
密歇根大学 (UM) HEAL Initiative 国家 K12 临床疼痛职业发展计划 (UM-HCPDP)
  • 批准号:
    10884563
  • 财政年份:
    2023
  • 资助金额:
    $ 58.35万
  • 项目类别:
University of Michigan (UM) HEAL Initiative National K12 Clinical Pain Career Development Program (UM-HCPDP)
密歇根大学 (UM) HEAL Initiative 国家 K12 临床疼痛职业发展计划 (UM-HCPDP)
  • 批准号:
    10596851
  • 财政年份:
    2022
  • 资助金额:
    $ 58.35万
  • 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
  • 批准号:
    10415416
  • 财政年份:
    2021
  • 资助金额:
    $ 58.35万
  • 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
  • 批准号:
    10395664
  • 财政年份:
    2021
  • 资助金额:
    $ 58.35万
  • 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
  • 批准号:
    10202826
  • 财政年份:
    2019
  • 资助金额:
    $ 58.35万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10690167
  • 财政年份:
    2019
  • 资助金额:
    $ 58.35万
  • 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
  • 批准号:
    9898106
  • 财政年份:
    2019
  • 资助金额:
    $ 58.35万
  • 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
  • 批准号:
    10765807
  • 财政年份:
    2019
  • 资助金额:
    $ 58.35万
  • 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
  • 批准号:
    10650650
  • 财政年份:
    2019
  • 资助金额:
    $ 58.35万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10765808
  • 财政年份:
    2019
  • 资助金额:
    $ 58.35万
  • 项目类别:

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无家可归者使用芬太尼兴奋剂多物质的纵向定性研究(行政补充)
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