Administrative Core

项目摘要/摘要 行政核心 密歇根大学(UM)bacpac MRC管理核心的优势之一是，所有 必要的领导技能、教员、工作人员和程序已经到位，并且已经存在多年。 提出这一MRC的领导团队有着相互合作的成功记录， 协调并成功地与大型跨学科调查小组合作，进行 多个项目同时进行，并成功传播研究成果。我们是少数几个痛苦的人之一 研究小组已经有几个正在进行的NIH中心拨款和R01，需要我们深入执行 正在进行的干预前后的表型研究--几乎与 Bacpac MRC.我们正在进行的一个中心资助(NIAMS CORT P50-AR070600)有一个内部 与MRC bacpac相同的组织结构，即一个大型研究项目由 几个研究核心和一个管理核心。我们的另一个中心赠款(NIDDK MAPP U01- DK082345)具有与BACPAC建议的几乎相同的外部网络结构。我们还有 许多正在进行的NIH或药物资助的综合研究使用了许多拟议的干预措施 我们的MRC，包括锻炼、认知行为疗法、穴位按摩和口服 止痛药。我们认为，已经在所有这些领域广泛工作的这一强大背景，既有 我们在密歇根大学建议的团队以及与世界各地的其他科学家一起，帮助加强我们的MRC 以两种方式申请：a)我们将更有可能实现我们在MRC中提出的建议 因为我们已经在做了，以及b)我们把许多标准化的研究方法和程序带到了 可考虑纳入更广泛的BACPAC网络努力的BACPAC。要解决这个问题 更大的UM bacpac MRC的需求管理核心将解决4个具体目标。首先，这个核心将 负责UM的内部规划、组织、协调和全面管理 Bacpac MRC.接下来，这一核心将有助于我们的UM MRC人员发挥关键的领导和支持作用 在我们的外部互动中的作用和对更广泛的BACPAC倡议的贡献。最后，核心将 将有关MRC操作和发现的信息传播给广泛的支持者，从科学家到 临床医生对病人的要求。

PROJECT SUMMARY / ABSTRACT ADMINISTRATIVE CORE One of the advantages of the University of Michigan (UM) BACPAC MRC Administrative Core is that all of the necessary leadership skills, faculty, staff, and procedures are already in place and have been for many years. The leadership team proposing this MRC has a successful track record of working together with each other, coordinating and successfully collaborating with large groups of inter-disciplinary investigators, conducting multiple projects simultaneously, and successfully disseminating research findings. We are one of few pain research groups that already has several ongoing NIH center grants and R01s that require us to perform deep phenotyping studies before and after ongoing interventions - almost identical to those proposed in the BACPAC MRC. One of our ongoing center grants (NIAMS CORT P50-AR070600) has an internal organizational structure identical to the MRC BACPAC, in that a single large research project is supported by several research cores as well as an Administrative Core. Our other center grant (NIDDK MAPP U01- DK082345) has an external, network structure nearly identical to that proposed for BACPAC. We also have many integrated ongoing NIH- or pharmaceutically funded studies using many of the proposed interventions in our MRC, including exercise, Cognitive Behavioral Therapies, acupressure, and orally-administered analgesics. We feel that this strong background of already working extensively in all of these areas, both with our proposed team at UM as well as with other scientists around the world, helps strengthen our MRC application in two ways: a) there is a greater likelihood we will be able to do what we propose in our MRC because we are already doing it, and b) we bring many standardized research methods and procedures to the BACPAC that might be considered for incorporation into broader BACPAC network efforts. To address the needs of the larger UM BACPAC MRC the Administrative Core will address 4 specific aims. First, this core will be responsible for the internal planning, organization, coordination, and overall administration of the UM BACPAC MRC. Next, this core will help facilitate our UM MRC personnel playing key leadership and support roles in our external interactions and contributions to the broader BACPAC initiative. Lastly, the core will disseminate information regarding the MRC operations and findings to a broad constituency, from scientists to clinicians to patients.