University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
基本信息
- 批准号:10415416
- 负责人:
- 金额:$ 9.86万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-01 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AcupressureAddressAlgorithmsAnalgesicsAutoimmune DiseasesAwardBack PainChronic low back painClinicalDataDiagnosticEffectivenessFatigueFunctional ImagingFunctional Magnetic Resonance ImagingGoalsHelping to End Addiction Long-termIndividualInflammationInterventionKnowledgeLeadershipLearning SkillLow Back PainMeasuresMethodsMichiganMind-Body InterventionModalityModelingNeurobiologyOnline SystemsPainPain MeasurementPain interferenceParentsPatient Outcomes AssessmentsPatientsPharmacologyPhenotypePhysical therapyPlasmaQuality of lifeRandomizedReportingResearchResearch DesignResearch MethodologyScientistSensorySeriesStandardizationTechnologyTestingTrainingTranslatingUniversitiesWorkautoimmune rheumatologic diseasebasechronic paincohortdisabilityduloxetineevidence baseexperiencefunctional disabilitygabapentinimprovedmindfulnessmindfulness interventionmindfulness-based stress reductionnoveloptimal treatmentspain patientpain reductionparent grantprecision medicinepredicting responseprogramsrandomized trialresponserheumatologistself-management programtreatment guidelinestreatment response
项目摘要
Project Summary / Abstract
Chronic low back pain (cLBP) is highly prevalent, expensive and is associated with long term functional
impairment, disability and poor quality of life. Several pharmacologic (e.g. duloxetine and gabapentin) and
non-pharmacologic treatments such as physical therapy, acupressure and mindfulness-based interventions
(MBIs) have shown efficacy in cLBP. Mindfulness-Based Stress-Reduction (MBSR) is an example of an
increasingly widely used non-pharmacological intervention for pain reduction, and is now recommended in
many treatment guidelines for cLBP. However, despite studies displaying effectiveness in cLBP, only a subset
of individuals responds to each treatment modality. There is an urgent need for a greater understanding of
pain mechanisms and predictors of response to different therapies with a goal of matching patients based on
phenotypes to therapies to which they are most likely to respond. The parent award, a HEAL Initiative award
(U19 AR076734), which uses a precision medicine approach to identify what treatments are likely to work in
different patient endotypes. The proposed supplement will allow the me, a clinical rheumatologist, to learn
these skills through assessment of MBSR on patient-reported pain interference in cLBP. I will also be able to
use both clinically available data (such as patient-reported outcomes) as well as state-of-art phenotyping
methods such as functional MRI (fMRI) and Quantitative Sensory Testing (QST), to mechanistically explore the
proposed neurobiological effects of MBSR. I will subsequently be able to translate this knowledge in how to
administer MBSR as well as evaluating pain mechanisms in individuals with autoimmune rheumatologic
diseases, and evaluate the patient phenotypes most responsive to different therapies.
项目总结/摘要
慢性下背痛(cLBP)是非常普遍的,昂贵的,并与长期功能性疼痛相关。
损伤、残疾和生活质量差。几种药理学(例如度洛沙汀和加巴喷丁)和
非药物治疗,如物理治疗,穴位按摩和正念干预
(MBIs)在cLBP中显示出疗效。正念减压(Mindfulness-Based Stress-Reduction,MBSR)是一个很好的例子。
越来越广泛地使用非药物干预来减轻疼痛,现在建议在
许多治疗CLBP的指南。然而,尽管研究显示对cLBP有效,但只有一个子集
对每种治疗方式都有反应。迫切需要更好地了解
疼痛机制和对不同治疗反应的预测因素,目标是根据以下因素匹配患者:
表型与他们最有可能产生反应的疗法相匹配。父母奖,一个治愈倡议奖
(U19 AR 076734),它使用精确医学方法来确定哪些治疗可能在
不同的患者内型。拟议的补充将允许我,一个临床风湿病学家,学习
这些技能通过评估正念减压对患者报告的疼痛干扰cLBP。我也能
使用临床可用数据(如患者报告的结局)以及最新的表型分析
功能性磁共振成像(fMRI)和定量感觉测试(QST)等方法,以机械地探索
正念减压疗法的神经生物学效应我随后将能够将这些知识转化为如何
管理MBSR以及评估自身免疫性风湿病患者的疼痛机制
疾病,并评估对不同疗法最有反应的患者表型。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Daniel J Clauw其他文献
Therapy Insight: fibromyalgia—a different type of pain needing a different type of treatment
治疗见解:纤维肌痛——一种需要不同类型治疗的不同类型疼痛
- DOI:
10.1038/ncprheum0221 - 发表时间:
2006-07-01 - 期刊:
- 影响因子:32.700
- 作者:
Dina Dadabhoy;Daniel J Clauw - 通讯作者:
Daniel J Clauw
Confocal microscopy reveals nerve fiber similarities in fibromyalgia and patients with dry eyes with a normal ophthalmic exam
- DOI:
10.1186/1744-8069-10-s1-p2 - 发表时间:
2014-12-15 - 期刊:
- 影响因子:2.800
- 作者:
Daniel E Harper;Vincent Pallazola;David A Williams;Steven Harte;Daniel J Clauw;Roni M Shtein - 通讯作者:
Roni M Shtein
Recommendations for Improving Systemic Lupus Erythematosus Care From Black Adults
改善黑人成人系统性红斑狼疮护理的建议
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:13.8
- 作者:
Bhaavna Yalavarthi;Johari Summerville;Nikki Farahani;Lillian Z. Xiao;Christine Yu;Deena Aboul;Sia Rajgarhia;Daniel J Clauw;J. M. Kahlenberg;Melissa DeJonckheere;Rachel S. Bergmans - 通讯作者:
Rachel S. Bergmans
Chronic overlapping pain conditions increase the risk of long COVID features, regardless of acute COVID status
无论急性新冠肺炎状态如何,慢性重叠疼痛都会增加长期新冠特征的风险
- DOI:
- 发表时间:
2023 - 期刊:
- 影响因子:7.4
- 作者:
Rachel S. Bergmans;Daniel J Clauw;Candace Flint;Herb Harris;Seth Lederman;A. Schrepf - 通讯作者:
A. Schrepf
230 - Long-Term Efficacy of Digital Acceptance and Commitment Therapy for Fibromyalgia: Follow-Up of the PROSPER-FM Trial At 12 Months
230 - 数字接纳与承诺疗法对纤维肌痛的长期疗效:PROSPER-FM 试验 12 个月随访
- DOI:
10.1016/j.jpain.2025.105028 - 发表时间:
2025-04-01 - 期刊:
- 影响因子:4.000
- 作者:
Michael J Rosenbluth;Dianne Shumay;Yifei Dai;R Michael Gendreau;Nicolette Vega;Lance M McCracken;David A Williams;Juan V Luciano;Andrea L Chadwick;Daniel J Clauw;Brian Keefe;Lesley M Arnold - 通讯作者:
Lesley M Arnold
Daniel J Clauw的其他文献
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{{ truncateString('Daniel J Clauw', 18)}}的其他基金
University of Michigan (UM) HEAL Initiative National K12 Clinical Pain Career Development Program (UM-HCPDP)
密歇根大学 (UM) HEAL Initiative 国家 K12 临床疼痛职业发展计划 (UM-HCPDP)
- 批准号:
10884563 - 财政年份:2023
- 资助金额:
$ 9.86万 - 项目类别:
University of Michigan (UM) HEAL Initiative National K12 Clinical Pain Career Development Program (UM-HCPDP)
密歇根大学 (UM) HEAL Initiative 国家 K12 临床疼痛职业发展计划 (UM-HCPDP)
- 批准号:
10596851 - 财政年份:2022
- 资助金额:
$ 9.86万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10395664 - 财政年份:2021
- 资助金额:
$ 9.86万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10398444 - 财政年份:2019
- 资助金额:
$ 9.86万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10202826 - 财政年份:2019
- 资助金额:
$ 9.86万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
9898106 - 财政年份:2019
- 资助金额:
$ 9.86万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10765807 - 财政年份:2019
- 资助金额:
$ 9.86万 - 项目类别:
University of Michigan BACPAC Mechanistic Research Center
密歇根大学BACPAC机理研究中心
- 批准号:
10650650 - 财政年份:2019
- 资助金额:
$ 9.86万 - 项目类别:
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