University of Michigan BACPAC Mechanistic Research Center

密歇根大学BACPAC机理研究中心

• 批准号: 10415416
• 负责人: Daniel J Clauw
• 金额: $ 9.86万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10415416
• 关键词: Acupressure; Address; Algorithms; Analgesics; Autoimmune Diseases; Award; Back Pain; Chronic low back pain; Clinical; Data; Diagnostic; Effectiveness; Fatigue; Functional Imaging; Functional Magnetic Resonance Imaging; Goals; Helping to End Addiction Long-term; Individual; Inflammation; Intervention; Knowledge; Leadership; Learning Skill; Low Back Pain; Measures; Methods; Michigan; Mind-Body Intervention; Modality; Modeling; Neurobiology; Online Systems; Pain; Pain Measurement; Pain interference; Parents; Patient Outcomes Assessments; Patients; Pharmacology; Phenotype; Physical therapy; Plasma; Quality of life; Randomized; Reporting; Research; Research Design; Research Methodology; Scientist; Sensory; Series; Standardization; Technology; Testing; Training; Translating; Universities; Work; autoimmune rheumatologic disease; base; chronic pain; cohort; disability; duloxetine; evidence base; experience; functional disability; gabapentin; improved; mindfulness; mindfulness intervention; mindfulness-based stress reduction; novel; optimal treatments; pain patient; pain reduction; parent grant; precision medicine; predicting response; programs; randomized trial; response; rheumatologist; self-management program; treatment guidelines; treatment response

Project Summary / Abstract Chronic low back pain (cLBP) is highly prevalent, expensive and is associated with long term functional impairment, disability and poor quality of life. Several pharmacologic (e.g. duloxetine and gabapentin) and non-pharmacologic treatments such as physical therapy, acupressure and mindfulness-based interventions (MBIs) have shown efficacy in cLBP. Mindfulness-Based Stress-Reduction (MBSR) is an example of an increasingly widely used non-pharmacological intervention for pain reduction, and is now recommended in many treatment guidelines for cLBP. However, despite studies displaying effectiveness in cLBP, only a subset of individuals responds to each treatment modality. There is an urgent need for a greater understanding of pain mechanisms and predictors of response to different therapies with a goal of matching patients based on phenotypes to therapies to which they are most likely to respond. The parent award, a HEAL Initiative award (U19 AR076734), which uses a precision medicine approach to identify what treatments are likely to work in different patient endotypes. The proposed supplement will allow the me, a clinical rheumatologist, to learn these skills through assessment of MBSR on patient-reported pain interference in cLBP. I will also be able to use both clinically available data (such as patient-reported outcomes) as well as state-of-art phenotyping methods such as functional MRI (fMRI) and Quantitative Sensory Testing (QST), to mechanistically explore the proposed neurobiological effects of MBSR. I will subsequently be able to translate this knowledge in how to administer MBSR as well as evaluating pain mechanisms in individuals with autoimmune rheumatologic diseases, and evaluate the patient phenotypes most responsive to different therapies.

项目摘要/摘要