Neuroplasticity in Auditory Aging

听觉衰老中的神经可塑性

• 批准号: 10201858
• 负责人: Sandra M Gordon-Salant
• 金额: $ 5.57万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10201858
• 关键词: Activities of Daily Living; Adult; Affect; Aging; Animal Model; Auditory; Behavioral; Brain; Communication; Cueing for speech; Cues; Data; Discrimination; Elderly; Electrophysiology (science); Goals; Hand; Hearing; Human; Impaired cognition; Investigation; Knowledge; Lead; Learning; Life; Measurement; Measures; Neuronal Plasticity; Outcome; Performance; Presbycusis; Process; Program Research Project Grants; Quality of life; Rehabilitation therapy; Research; Speech; Speech Perception; Stimulus; Techniques; Testing; Training; age effect; age related; behavioral outcome; experience; experimental study; hearing impairment; human model; improved; innovation; normal hearing; novel; relating to nervous system; young adult

PROJECT 2 – ABSTRACT The detrimental effects of aging on auditory temporal processing have been well documented in humans and animal models. At present, there are gaps in knowledge of the extent to which these auditory temporal processing deficits can be mitigated in older adults with or without hearing loss through auditory training and neuroplasticity, to improve precision of neural timing and speech understanding. Our long-term goal is to determine the extent to which hearing deficits in older adults can be ameliorated with auditory training. We propose an innovative approach to the investigation of aging, hearing, and neuroplasticity by marrying perceptual training experiments with electrophysiological measurements. The objectives are to compare young normal-hearing (YNH), older nor- mal-hearing (ONH), young hearing-impaired, (YHI), and older hearing-impaired (OHI) adult listeners, and eval- uate the improvements in perceptual and electrophysiological measures of temporal processing after explicit training on auditory temporal processing tasks. Our central hypothesis is that training of auditory temporal pro- cessing will produce concomitant improvements in both perceptual performance and neural encoding, which will close the gap in the age-related differences between groups. With strong preliminary data in hand, the central hypothesis will be tested by pursuing three specific aims: (1) Determine the extent to which perceptual training on temporal rate discrimination using simple non-speech stimuli improves perceptual and neural encoding in YNH, YHI, ONH, and OHI listeners; (2) Determine the extent to which perceptual training on speech cue dis- crimination in contrasting words differing in discrete temporal cues improves perceptual and neural encoding in YNH, YHI, ONH, and OHI listeners; and (3) Determine the extent to which perceptual training on the processing of sentences with increasing presentation rate can improve behavioral performance and neural encoding in YNH, YHI, ONH, and OHI listeners. The expected outcomes are that we will learn what perceptual training tasks lead to simultaneous improvements in perceptual and neural auditory temporal processing and the findings will pro- duce a significant impact in older listeners who experience difficulty in communicating in daily life because they will lead directly to focused and novel forms of rehabilitation. This research is innovative because we will have established techniques that are proven to provide significant improvements in auditory temporal processing and speech perception, combined with evidence of improvements to neural encoding. These studies will serve the larger goals of the program project grant because they will help identify the neuroplastic mechanisms in the brain of humans that correspond to successful behavioral outcomes in younger and older adults. These studies will serve the larger goals of the program project grant because they will help identify the neuroplastic mechanisms in the brain of humans that correspond to successful behavioral outcomes in younger and older adults.

项目 2 – 摘要 衰老对听觉时间处理的有害影响已在人类和人类中得到充分记录。 动物模型。目前，对于这些听觉时间处理的程度还存在认识上的空白。 通过听觉训练和神经可塑性可以减轻有或没有听力损失的老年人的缺陷， 提高神经计时和语音理解的精度。我们的长期目标是确定 通过听觉训练可以改善老年人的听力缺陷。我们提出了一个创新的 通过结合感知训练实验来研究衰老、听力和神经可塑性的方法 与电生理测量。目标是比较年轻人听力正常 (YNH)、老年听力正常者 听力障碍 (ONH)、年轻听力障碍 (YHI) 和老年听力障碍 (OHI) 成年听众，以及评估 评估显式治疗后时间处理的知觉和电生理测量的改善 听觉时间处理任务的训练。我们的中心假设是听觉时间亲和力的训练 停止将带来感知表现和神经编码的伴随改进，这将 缩小群体之间与年龄相关的差异的差距。中央掌握了强有力的初步数据 假设将通过追求三个具体目标来检验：（1）确定感知训练的程度 使用简单的非语音刺激的时间速率辨别可以改善感知和神经编码 YNH、YHI、ONH 和 OHI 听众； (2) 确定言语提示感知训练的程度 离散时间线索不同的对比词的犯罪改善了感知和神经编码 YNH、YHI、ONH 和 OHI 听众； (3) 确定处理过程中感知训练的程度 提高呈现率的句子可以改善 YNH 的行为表现和神经编码， YHI、ONH 和 OHI 听众。预期的结果是我们将了解感知训练任务会带来什么 知觉和神经听觉时间处理的同时改善，研究结果将有利于 这对年长听众产生了重大影响，他们在日常生活中遇到沟通困难，因为他们 将直接导致有针对性的新颖的康复形式。这项研究具有创新性，因为我们将 已被证明可以显着改善听觉时间处理和 语音感知，结合神经编码改进的证据。这些研究将服务于 该计划项目资助的更大目标是因为它们将有助于识别大脑中的神经可塑性机制 与年轻人和老年人的成功行为结果相对应的人类。这些研究将 服务于该计划项目拨款的更大目标，因为它们将有助于识别神经可塑性机制 在人类大脑中，与年轻人和老年人的成功行为结果相对应。