UC Davis Environmental Health Sciences Core Center

项目概要-总体 加州大学戴维斯分校环境健康科学中心（EHSC）的使命是促进对 环境引起的疾病和残疾，并将这些知识转化为干预措施，新的 减少这些接触或减轻其对健康影响的做法或政策变化。EHSC带来了 来自七所从事环境健康科学（EHS）研究的学校和学院的教师一起 横跨分子生物科学、环境科学、工程学、病理生理学、生物统计学、 流行病学和社区发展，与人类条件有关。EHSC已经做出了巨大的 在不到四年的时间里取得了长足的进步。在其显着的成就，EHSC有：突破筒仓， 将跨学科合作转变为我们成员之间的标准工作方式，吸引了 新的和建立的调查人员，并把环境健康的雷达上的其他中心 整个加州大学戴维斯分校EHSC成员越来越多地与社区利益相关者接触，并寻求 解决社区驱动的问题。EHSC的几个突出成就是：1）一个新颖的动物园 利用从交通繁忙的隧道中抽取的实时空气进行空气污染健康研究的设施; 2）一个程序 针对巨大破坏性野火的暴露和健康影响的研究现在已经司空见惯 在美国西部，3)征聘许多新的调查员，包括两名任职人数偏低的调查员 少数群体妇女;在社交媒体上建立强大的影响力。NIEHS 2018-2023 战略计划和NIEHS转化研究框架，我们通过了三个首要主题 领域：1）跨学科的翻译EHS连接分子/细胞培养实验，整个动物测定， 人类流行病学研究，干预措施和政策; 2）环境，社会正义和 了解脆弱性和复原力; 3）与社区，临床医生和政策建立桥梁- 创客在这些广泛的主题上分层，我们继续培养UCD在研究方面的历史优势， 呼吸，神经，免疫，代谢，内分泌和生殖系统，最近扩展到 癌症和气候相关的健康研究。该中心有一个试点项目计划和四个核心： 管理，综合健康科学，暴露科学和社区参与，以及 各种咨询委员会。在未来的资助期内，加州大学戴维斯分校EHSC将扩大其范围， 影响：1）推进暴露特征、环境健康影响、 分子生物学机制和改进照射测量的技术发展， 生物标志物; 2）扩大EHS研究人员的干部队伍，以及3）与政策制定者，社区 利益相关者和卫生专业人员，以确保我们的研究的相关性，并将结果转化为公众 健康改善。该中心强调跨学科和翻译的方法，以环境 健康问题，并与整个加州大学戴维斯分校的其他中心发展伙伴关系。

PROJECT SUMMARY - Overall The mission of the UC Davis Environmental Health Sciences Center (EHSC) is to advance understanding of environmentally induced disease and disability and to translate this knowledge into interventions, new practices or policy changes that reduce those exposures or mitigate their effects on health. The EHSC brings together faculty from seven schools and colleges engaged in environmental health sciences (EHS) research spanning molecular biosciences, environmental science, engineering, pathophysiology, biostatistics, epidemiology, and community development, with relevance to human conditions. The EHSC has made huge strides in less than 4 years. Among its notable achievements, the EHSC has: broken through silos, transformed interdisciplinary collaboration into the standard modus operandi among our members, attracted both new and established investigators, and placed environmental health on the radar of other Centers throughout UC Davis. Increasingly, EHSC members are engaging with community stakeholders and seeking to address community-driven questions. A few highlights of EHSC accomplishments are: 1) a novel vivarium facility for air pollution health studies using real-time air pumped from a heavily trafficked tunnel; 2) a program of research on exposures and health effects in response to hugely destructive wildfires now commonplace throughout the western U.S.; 3) recruitment of many new investigators, including two underrepresented minority women; establishment of a strong presence on social media. Guided by the NIEHS 2018-2023 Strategic Plan and the NIEHS Translational Research Framework, we adopted three overarching theme areas: 1) interdisciplinary translational EHS linking molecular/cell culture experiments, whole animal assays, human epidemiologic research, interventions, and policy; 2) integration of environment, social justice and health to understand vulnerability and resilience; 3) building bridges with communities, clinicians, and policy- makers. Layered on those broad themes, we continue to cultivate the historic UCD strengths in research on respiratory, nervous, immune, metabolic, endocrine, and reproductive systems, and recently expanded into cancer and climate-related health research. The Center has a Pilot Projects Program and four cores: Administration, Integrative Health Sciences, Exposure Sciences and Community Engagement, as well as various advisory committees. In the coming funding period, the UC Davis EHSC will expand its scope and impact by 1) advancing cutting-edge research in exposure characterization, environmental health effects, their molecular biologic mechanisms, and technology development for improving measurement of exposures and biomarkers; 2) enlarging the cadre of EHS researchers, and 3) engaging with policy-makers, community stakeholders and health professionals, to ensure relevance of our research and to translate findings into public health improvement. The Center emphasizes inter-disciplinary and translational approaches to environmental health issues and is developing partnerships with other Centers throughout UC Davis.