Biostatistics, Bioinformatics and Research Design Core

加州大学戴维斯分校心智研究所IDDRC生物统计学、生物信息学和研究设计的重点 (BBRD)的核心是提供集中的统计支持、培训和高级分析开发 满足我们的研究人员及其项目需求的方法。国际民主与发展中心的项目增进了对 IDD的条件及其基础生物学，开发可以减轻发病率和改善 长期结果，并确定可以修改的原因因素，以减少未来的发病率。国际直拨电话 感兴趣的情况包括自闭症谱系障碍(ASD)、注意缺陷多动障碍 多动症(ADHD)，脆性X综合征(FXS)，染色体22q11.2缺失综合征，21三体，特发性 ID/发育迟缓，以及一系列其他影响认知、社交技能、行为、适应能力的条件 功能，以及各种器官系统。精神研究所IDDRC接纳了精神病学的教员， 行为科学，神经科学，发育儿科学，神经学，流行病学，免疫学，遗传学， 分子生物学、产科、生物统计学等。IDDRC的研究是通过以人口为基础进行的 流行病学、临床研究、动物模型和体外细胞系统。建议的广度和深度 IDDRC项目及其对最先进的分析方法的特殊需求，这些方法解决纵向、 对表型和基因数据进行高维、综合处理需要先进的 具有高度专业化的专业知识。BBRD核心是思维研究所的新资源， 加州大学戴维斯分校的研究人员正在研究IDD。该核心旨在通过提供对 咨询具有广泛互补专业知识的生物统计学家和一位能够 与生物统计学家和IDDRC调查员合作进行指定的分析。我们 我们将通过以下具体目标实现我们的目标： 1.为思维研究所IDDRC多个学科的研究人员提供统计支持，以推动 碘缺乏病的翻译科学。这种支持将包括设计、分析(特别是复杂数据)、 以及对结果的解释。 2.在分析技术方面为前沿项目开发新的统计方法(即， 当现有方法不充分时)，并使软件和方法可用于整个研究 社区通过出版物。 3.为IDDRC研究人员提供数据库支持，包括临床试验和其他设计、数据录入 接口和基于查询的功能。 4.帮助培训和指导博士生、博士后学者和国际发展研究中心 生物统计学和研究设计领域的研究人员。

The focus of the UC Davis MIND Institute IDDRC Biostatistics, Bioinformatics, and Research Design (BBRD) Core is to provide centralized statistical support, training, and development of advanced analytic methods that meet the needs of our investigators and their projects. IDDRC projects advance knowledge of IDD conditions and their underlying biology, develop treatments that can mitigate the morbidity and improve long-term outcomes, and identify causal factors that can be modified to reduce incidence in the future. IDD conditions of interest include autism spectrum disorders (ASD), Attention Deficit Hyperactivity Disorder (ADHD), fragile X syndrome (FXS), Chromosome 22q11.2 deletion syndrome, trisomy 21, idiopathic ID/developmental delay, and an array of other conditions that affect cognition, social skills, behaviors, adaptive function, and a variety of organ systems. The MIND Institute IDDRC embraces faculty from psychiatry, behavioral science, neuroscience, developmental pediatrics, neurology, epidemiology, immunology, genetics, molecular biology, obstetrics, biostatistics and others. IDDRC research is conducted through population-based epidemiology, clinical studies, animal models, and in vitro cell systems. The breadth and depth ofthe proposed IDDRC projects and their particular needs for state-of-the-art analytic approaches that address longitudinal, high-dimensional, and integrative treatment of data on both phenotype and genotype require advanced expertise with a high degree of specialization. The BBRD Core is a new resource for the MIND Institute and UC Davis researchers studying IDD. The core is designed to meet these needs by providing access to consulting biostatisticians with a broad range of complementary expertise and a core manager who will be able to work collaboratively with the biostatisticians and IDDRC investigator to conduct the specified analyses. We will achieve our objectives through the following Specific Aims: 1. Provide statistical support to MIND Institute IDDRC investigators from a range of disciplines to advance the translational science of IDD. This support will encompass design, analysis (especially for complex data), and interpretation of results. 2. Develop new statistical methodology for cutting-edge projects in terms of analysis techniques (i.e., when existing methodology is inadequate) and to make software and methods available to the entire research community through publications. 3. Provide database support for IDDRC investigators, including clinical trials and other designs, data entry interface, and query-based capabilities. 4. Contribute to the training and mentoring of doctoral students, postdoctoral scholars, and IDDRC investigators in the areas of biostatistics and research design.