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Mentoring Clinical Investigators in Adolescent-onset Substance Use Disorders Research

指导临床研究人员进行青少年发作的药物使用障碍研究

基本信息

批准号：
10197062
负责人：
Christian J Hopfer
金额：
$ 18.33万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-04-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10197062
关键词：
Adolescent Anesthesiology Area Award Behavioral Genetics Biological Markers Biometry Clinical Clinical Investigator Collaborations Colorado Development Discipline Disease Doctor of Medicine Doctor of Philosophy Educational process of instructing Epidemiology Etiology Family Family Study Funding Genetic Goals Grant Individual Joints K-Series Research Career Programs Leadership Marijuana Maternal-fetal medicine Measurement Medical Students Mentors Mentorship Mid-Career Clinical Scientist Award (K24)Mission Molecular Molecular Genetics Molecular and Cellular Biology National Institute of Drug Abuse Outcome Paper Pediatrics Pharmacology Proteomics Psychiatry Public Health Research Research Design Research Personnel Research Training Role Substance Use Disorder Substance abuse problem Systems Biology Technology Time Toxicology Training Twin Multiple Birth Universities Work Writing Youth addiction behavioral outcome biomarker discovery career career development developmental psychobiology education research genetic approach high risk lipidomics marijuana legalization marijuana use medical schools metabolomics patient oriented patient oriented research programs public health relevance responsible research conduct senior faculty skills student training substance use success transcriptome sequencing

项目摘要

The primary goals of this K24 competing renewal application are to enable Christian Hopfer, M.D. to conduct career development activities to enhance his patient-oriented addiction research and to provide high-quality mentorship to early-career investigators. The renewal will enable Dr. Hopfer to have protected time to devote to career development and mentoring of clinical researchers. Dr. Hopfer was promoted to Full Professor of Psychiatry at the University of Colorado School of Medicine due to the success of his research, teaching, and clinical program. Dr. Hopfer's major goals of his initial award were accomplished with obtaining and leading a NIDA funded R25 medical student research education program, acting as the executive director of the Developmental Psychobiology Research Group (DPRG) whose affiliated T32 program was renewed, obtaining new research funding, and mentoring junior investigators. Dr.Hopfers' research plan for this renewal application involves continued work as a PI on NIDA funded research focused on understanding genetic and environmental influences on the progression or desistance of substance use disorders among high-risk youth utilizing a joint twin/family study design as well as understanding the impact of legal marijuana access on psychiatric and behavioral outcomes. He plans to expand his search for biomarkers for substance use disorders that have been previously conducted utilizing molecular genetic approaches to now include proteomic, metabolomics, RNA-seq, and lipidomic approaches. Dr.Hopfer mentors trainees in multiple areas of research training including: 1) Understanding clinical aspects of substance use and abuse, 2) Twin/family and molecular approaches to examining the etiology of substance use and correlated disorders, 3) Preparing scientific papers and presenting findings, 4) Developing and writing successful project proposals, and 5) conducting responsible research. He will accomplish his training mission through individual and group mentoring and collaborating with key colleagues with expertise in biostatistics and state of the art measurement technologies for identifying biomarkers of substance use.

这个K24竞争更新应用程序的主要目标是使Christian Hopfer，