Mentoring Clinical Investigators in Adolescent-onset Substance Use Disorders Research

此K24竞争续订申请的主要目标是使Christian Hopfer能够， 医学博士将开展职业发展活动，以增强其以病人为导向的成瘾 并为职业生涯初期的研究人员提供高质量的指导。续签将 使霍普弗博士有足够的时间致力于职业发展和指导 临床研究人员。霍普费尔博士被提升为加州大学精神病学正教授 科罗拉多医学院，由于他的研究、教学和临床项目的成功。 霍普费尔博士最初获奖的主要目标是通过获得和领导一个 NIDA资助R25医学生研究教育项目，担任执行董事 发展心理生物学研究组(DPRG)，其附属的T32计划 获得新的研究资金，并指导初级调查人员。 霍普弗斯博士对这一续订申请的研究计划包括作为NIDA的PI继续工作 资助的研究重点是了解遗传和环境对健康的影响 使用关节的高危青年中物质使用障碍的进展或停止 双胞胎/家庭研究设计以及了解合法获得大麻对 精神和行为结果。他计划扩大对生物标记物的搜索 以前利用分子遗传学进行的物质使用障碍 现在的方法包括蛋白质组学、代谢组学、RNA-SEQ和脂质组学方法。 Hopfer博士在多个研究培训领域指导受训人员，包括：1)理解 药物使用和滥用的临床方面，2)双胞胎/家庭和分子方法 检查物质使用和相关疾病的病因，3)准备科学论文 和提出调查结果，4)开发和撰写成功的项目提案，5) 进行负责任的研究。他将通过个人和个人完成他的训练任务 与具有生物统计学专业知识的关键同事进行小组指导和协作 用于识别物质使用的生物标志物的ART测量技术。

The primary goals of this K24 competing renewal application are to enable Christian Hopfer, M.D. to conduct career development activities to enhance his patient-oriented addiction research and to provide high-quality mentorship to early-career investigators. The renewal will enable Dr. Hopfer to have protected time to devote to career development and mentoring of clinical researchers. Dr. Hopfer was promoted to Full Professor of Psychiatry at the University of Colorado School of Medicine due to the success of his research, teaching, and clinical program. Dr. Hopfer's major goals of his initial award were accomplished with obtaining and leading a NIDA funded R25 medical student research education program, acting as the executive director of the Developmental Psychobiology Research Group (DPRG) whose affiliated T32 program was renewed, obtaining new research funding, and mentoring junior investigators. Dr.Hopfers' research plan for this renewal application involves continued work as a PI on NIDA funded research focused on understanding genetic and environmental influences on the progression or desistance of substance use disorders among high-risk youth utilizing a joint twin/family study design as well as understanding the impact of legal marijuana access on psychiatric and behavioral outcomes. He plans to expand his search for biomarkers for substance use disorders that have been previously conducted utilizing molecular genetic approaches to now include proteomic, metabolomics, RNA-seq, and lipidomic approaches. Dr.Hopfer mentors trainees in multiple areas of research training including: 1) Understanding clinical aspects of substance use and abuse, 2) Twin/family and molecular approaches to examining the etiology of substance use and correlated disorders, 3) Preparing scientific papers and presenting findings, 4) Developing and writing successful project proposals, and 5) conducting responsible research. He will accomplish his training mission through individual and group mentoring and collaborating with key colleagues with expertise in biostatistics and state of the art measurement technologies for identifying biomarkers of substance use.