Mentoring Clinical Investigators in Adolescent-onset Substance Use Disorders Research

这个K24竞争更新应用程序的主要目标是使基督教霍普费尔， M.D.进行职业发展活动，以提高他的病人为导向的成瘾 研究，并提供高质量的指导，以早期职业生涯的调查。续发行 使Hopfer博士有受保护的时间致力于职业发展和指导 临床研究者霍普弗博士被提升为芝加哥大学精神病学教授。 科罗拉多医学院由于他的研究，教学和临床计划的成功。 博士霍普弗的主要目标，他最初的奖项是完成与获得和领导一个 NIDA资助的R25医学生研究教育计划，担任执行主任 发展心理生物学研究小组（DPRG）的附属T32项目 更新，获得新的研究资金，并指导初级研究人员。 霍普弗斯博士的研究计划，这一更新申请涉及继续工作，作为一个PI对NIDA 资助的研究重点是了解遗传和环境对 使用关节的高危青年中物质使用障碍的进展或停止 双胞胎/家庭研究设计以及了解法律的大麻获取对 精神和行为结果。他计划扩大对生物标志物的研究， 先前已经利用分子遗传学进行的物质使用障碍 目前的方法包括蛋白质组学、代谢组学、RNA-seq和脂质组学方法。 霍普弗博士在多个研究培训领域指导学员，包括：1）理解 药物使用和滥用的临床方面，2）双胞胎/家庭和分子方法， 检查物质使用和相关疾病的病因，3）编写科学论文 4）制定和编写成功的项目提案，以及5） 进行负责任的研究。他将通过个人和个人训练完成他的训练使命， 小组指导和与具有生物统计学和国家统计学专业知识的主要同事合作 用于鉴定物质使用的生物标志物的现有技术测量技术。

The primary goals of this K24 competing renewal application are to enable Christian Hopfer, M.D. to conduct career development activities to enhance his patient-oriented addiction research and to provide high-quality mentorship to early-career investigators. The renewal will enable Dr. Hopfer to have protected time to devote to career development and mentoring of clinical researchers. Dr. Hopfer was promoted to Full Professor of Psychiatry at the University of Colorado School of Medicine due to the success of his research, teaching, and clinical program. Dr. Hopfer's major goals of his initial award were accomplished with obtaining and leading a NIDA funded R25 medical student research education program, acting as the executive director of the Developmental Psychobiology Research Group (DPRG) whose affiliated T32 program was renewed, obtaining new research funding, and mentoring junior investigators. Dr.Hopfers' research plan for this renewal application involves continued work as a PI on NIDA funded research focused on understanding genetic and environmental influences on the progression or desistance of substance use disorders among high-risk youth utilizing a joint twin/family study design as well as understanding the impact of legal marijuana access on psychiatric and behavioral outcomes. He plans to expand his search for biomarkers for substance use disorders that have been previously conducted utilizing molecular genetic approaches to now include proteomic, metabolomics, RNA-seq, and lipidomic approaches. Dr.Hopfer mentors trainees in multiple areas of research training including: 1) Understanding clinical aspects of substance use and abuse, 2) Twin/family and molecular approaches to examining the etiology of substance use and correlated disorders, 3) Preparing scientific papers and presenting findings, 4) Developing and writing successful project proposals, and 5) conducting responsible research. He will accomplish his training mission through individual and group mentoring and collaborating with key colleagues with expertise in biostatistics and state of the art measurement technologies for identifying biomarkers of substance use.