A family study of substance use & conduct disorder

物质使用的家庭研究

• 批准号: 6684821
• 负责人: Christian J Hopfer
• 金额: $ 41.82万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-10 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6684821
• 关键词: adolescence (12-20); antisocial personality; behavior test; behavioral /social science research tag; clinical research; comorbidity; conduct disorder; family genetics; family structure /dynamics; genetic screening; human subject; interview; legal /correctional; parent offspring interaction; questionnaires; sibling relations; statistics /biometry; substance abuse related behavior; substance abuse related disorder

DESCRIPTION (provided by applicant): This is a proposal to expand a family study of adjudicated adolescent boys and girls with Substance Use Disorders (SUD) and Conduct Disorder (CD). In this revised application, we propose to evaluate the families of 400 adolescent probands, identified through court records, as well as 200 controls and their family members. Expanding the study to include more families will allow for an adequate sample size to discriminate between different comorbidity models of SUD and CD and the assessment of parental and sibling influences on SUD and CD. DNA will be collected in order to assess for degree of genetic relatedness and non-paternity. The specific aims of the proposal are to: 1) test competing models of the comorbidity between SUD and CD in sibling pairs, where one of the siblings is an adjudicated adolescent, 2) examine the influence of parents and siblings on the development of SUD and CD in families with at least one adjudicated adolescent, and 3) compare the observed familial aggregation of SUD and CD between the proposed sample and a sample of families of youth in treatment for SUD and CD. SUD and CD are severe, life-threatening conditions of adolescence. Mortality rates among such adolescents reportedly are fivefold greater than among their age-mates. This research may lead to the identification of familial influences influencing the expression of these pathological behaviors. This may lead to improved phenotypes, improving the search for specific genetic or environmental causes of these destructive behaviors. The ultimate goal of this research is to reverse that process through therapeutic correction of those pathological genetic or environmental factors.

描述（由申请人提供）：这是一项扩大对具有物质使用障碍（SUD）和行为障碍（CD）的裁决青少年男孩和女孩的家庭研究的建议。在此修订后的申请中，我们建议评估通过法院记录确定的400个青少年概率的家庭，以及200个控制及其家人。扩大研究以包括更多家庭将允许有足够的样本量来区分SUD和CD的不同合并症模型以及对父母和兄弟姐妹对SUD和CD的影响的评估。将收集DNA，以评估遗传相关性和非流行性的程度。该提案的具体目的是：1）在兄弟姐妹对中SUD和CD之间合并症的竞争模型，其中之一是兄弟姐妹是一个裁决的青少年，2）研究父母和兄弟姐妹对至少一个审查的家庭审查的家族和CD的家庭的us和CD的影响，并在审查中进行了审查的习惯，并在审查中进行了审查，并在审查中进行了审查的习惯和CD的习惯。和CD。 SUD和CD是严重的，威胁生命的青春期条件。据报道，这类青少年的死亡率比其年龄伴侣高五倍。这项研究可能导致鉴定家庭影响，从而影响这些病理行为的表达。这可能会导致改进的表型，从而改善对这些破坏性行为的特定遗传或环境原因的搜索。这项研究的最终目的是通过对这些病理遗传或环境因素的治疗校正来扭转这一过程。