Mentoring Clinical Investigators in Adolescent-onset Substance Use Disorders Research

指导临床研究人员进行青少年发作的药物使用障碍研究

基本信息

批准号：
10425382
负责人：
Christian J Hopfer
金额：
$ 18.33万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-04-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10425382
关键词：
Adolescent Anesthesiology Area Award Behavioral Genetics Biological Markers Biometry Clinical Clinical Investigator Collaborations Colorado Development Discipline Disease Doctor of Medicine Doctor of Philosophy Educational process of instructing Epidemiology Etiology Family Family Study Funding Genetic Goals Grant Individual Joints K-Series Research Career Programs Leadership Marijuana Maternal-fetal medicine Measurement Medical Students Mentors Mentorship Mid-Career Clinical Scientist Award (K24)Mission Molecular Molecular Genetics Molecular and Cellular Biology National Institute of Drug Abuse Outcome Paper Pediatrics Pharmacology Proteomics Psychiatry Public Health Research Research Design Research Personnel Research Training Role Substance Use Disorder Substance abuse problem Systems Biology Technology Time Toxicology Training Twin Multiple Birth Universities Work Writing Youth addiction behavioral outcome biomarker discovery career career development developmental psychobiology education research genetic approach high risk lipidomics marijuana legalization marijuana use medical schools metabolomics patient oriented patient oriented research programs public health relevance responsible research conduct senior faculty skills student training substance use success transcriptome sequencing

项目摘要

The primary goals of this K24 competing renewal application are to enable Christian Hopfer, M.D. to conduct career development activities to enhance his patient-oriented addiction research and to provide high-quality mentorship to early-career investigators. The renewal will enable Dr. Hopfer to have protected time to devote to career development and mentoring of clinical researchers. Dr. Hopfer was promoted to Full Professor of Psychiatry at the University of Colorado School of Medicine due to the success of his research, teaching, and clinical program. Dr. Hopfer's major goals of his initial award were accomplished with obtaining and leading a NIDA funded R25 medical student research education program, acting as the executive director of the Developmental Psychobiology Research Group (DPRG) whose affiliated T32 program was renewed, obtaining new research funding, and mentoring junior investigators. Dr.Hopfers' research plan for this renewal application involves continued work as a PI on NIDA funded research focused on understanding genetic and environmental influences on the progression or desistance of substance use disorders among high-risk youth utilizing a joint twin/family study design as well as understanding the impact of legal marijuana access on psychiatric and behavioral outcomes. He plans to expand his search for biomarkers for substance use disorders that have been previously conducted utilizing molecular genetic approaches to now include proteomic, metabolomics, RNA-seq, and lipidomic approaches. Dr.Hopfer mentors trainees in multiple areas of research training including: 1) Understanding clinical aspects of substance use and abuse, 2) Twin/family and molecular approaches to examining the etiology of substance use and correlated disorders, 3) Preparing scientific papers and presenting findings, 4) Developing and writing successful project proposals, and 5) conducting responsible research. He will accomplish his training mission through individual and group mentoring and collaborating with key colleagues with expertise in biostatistics and state of the art measurement technologies for identifying biomarkers of substance use.

这项K24竞争续约应用的主要目标是使基督教霍夫（Christian Hopfer），医学博士开展职业发展活动以增强其面向患者的成瘾研究并向早期研究人员提供高质量的指导。更新意志使Hopfer博士能够保护时间来投入职业发展和指导临床研究人员。霍普弗博士被提升为大学的全部精神病学教授科罗拉多州医学院的研究，教学和临床计划的成功。 Hopfer博士的最初奖项的主要目标是通过获得并领导A的 NIDA资助了R25医学学生研究教育计划，担任执行董事隶属于T32计划的发展心理生物学研究小组（DPRG）被续签，获得了新的研究资金，并指导了初级研究人员。 Hopfers博士的续签应用研究计划涉及NIDA的PI继续工作资金研究的重点是理解遗传和环境对利用联合的高风险青年中物质使用障碍的进展或停止性双胞胎/家庭研究设计以及了解合法大麻访问的影响精神病和行为结果。他计划扩大对生物标志物的搜索先前利用分子遗传的药物使用障碍现在的方法包括蛋白质组学，代谢组学，RNA-seq和脂肪组方法。 Hopfer博士导师在多个研究培训领域的学员，包括：1）理解物质使用和滥用的临床方面，2）双胞胎/家庭和分子方法检查物质使用和相关性疾病的病因，3）准备科学论文并提出发现，4）制定和撰写成功的项目建议，以及5）进行负责任的研究。他将通过个人完成培训任务，小组指导和与主要同事合作，具有生物统计学和状态专业知识用于识别物质使用的生物标志物的ART测量技术。