Mentoring Clinical Investigators in Adolescent-onset Substance Use Disorders Research
指导临床研究人员进行青少年发作的药物使用障碍研究
基本信息
- 批准号:10425382
- 负责人:
- 金额:$ 18.33万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-04-01 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:AdolescentAnesthesiologyAreaAwardBehavioral GeneticsBiological MarkersBiometryClinicalClinical InvestigatorCollaborationsColoradoDevelopmentDisciplineDiseaseDoctor of MedicineDoctor of PhilosophyEducational process of instructingEpidemiologyEtiologyFamilyFamily StudyFundingGeneticGoalsGrantIndividualJointsK-Series Research Career ProgramsLeadershipMarijuanaMaternal-fetal medicineMeasurementMedical StudentsMentorsMentorshipMid-Career Clinical Scientist Award (K24)MissionMolecularMolecular GeneticsMolecular and Cellular BiologyNational Institute of Drug AbuseOutcomePaperPediatricsPharmacologyProteomicsPsychiatryPublic HealthResearchResearch DesignResearch PersonnelResearch TrainingRoleSubstance Use DisorderSubstance abuse problemSystems BiologyTechnologyTimeToxicologyTrainingTwin Multiple BirthUniversitiesWorkWritingYouthaddictionbehavioral outcomebiomarker discoverycareercareer developmentdevelopmental psychobiologyeducation researchgenetic approachhigh risklipidomicsmarijuana legalizationmarijuana usemedical schoolsmetabolomicspatient orientedpatient oriented researchprogramspublic health relevanceresponsible research conductsenior facultyskillsstudent trainingsubstance usesuccesstranscriptome sequencing
项目摘要
The primary goals of this K24 competing renewal application are to enable Christian Hopfer,
M.D. to conduct career development activities to enhance his patient-oriented addiction
research and to provide high-quality mentorship to early-career investigators. The renewal will
enable Dr. Hopfer to have protected time to devote to career development and mentoring of
clinical researchers. Dr. Hopfer was promoted to Full Professor of Psychiatry at the University of
Colorado School of Medicine due to the success of his research, teaching, and clinical program.
Dr. Hopfer's major goals of his initial award were accomplished with obtaining and leading a
NIDA funded R25 medical student research education program, acting as the executive director
of the Developmental Psychobiology Research Group (DPRG) whose affiliated T32 program
was renewed, obtaining new research funding, and mentoring junior investigators.
Dr.Hopfers' research plan for this renewal application involves continued work as a PI on NIDA
funded research focused on understanding genetic and environmental influences on the
progression or desistance of substance use disorders among high-risk youth utilizing a joint
twin/family study design as well as understanding the impact of legal marijuana access on
psychiatric and behavioral outcomes. He plans to expand his search for biomarkers for
substance use disorders that have been previously conducted utilizing molecular genetic
approaches to now include proteomic, metabolomics, RNA-seq, and lipidomic approaches.
Dr.Hopfer mentors trainees in multiple areas of research training including: 1) Understanding
clinical aspects of substance use and abuse, 2) Twin/family and molecular approaches to
examining the etiology of substance use and correlated disorders, 3) Preparing scientific papers
and presenting findings, 4) Developing and writing successful project proposals, and 5)
conducting responsible research. He will accomplish his training mission through individual and
group mentoring and collaborating with key colleagues with expertise in biostatistics and state of
the art measurement technologies for identifying biomarkers of substance use.
此K24竞争续订申请的主要目标是使Christian Hopfer能够,
医学博士将开展职业发展活动,以增强其以病人为导向的成瘾
并为职业生涯初期的研究人员提供高质量的指导。续签将
使霍普弗博士有足够的时间致力于职业发展和指导
临床研究人员。霍普费尔博士被提升为加州大学精神病学正教授
科罗拉多医学院,由于他的研究、教学和临床项目的成功。
霍普费尔博士最初获奖的主要目标是通过获得和领导一个
NIDA资助R25医学生研究教育项目,担任执行董事
发展心理生物学研究组(DPRG),其附属的T32计划
获得新的研究资金,并指导初级调查人员。
霍普弗斯博士对这一续订申请的研究计划包括作为NIDA的PI继续工作
资助的研究重点是了解遗传和环境对健康的影响
使用关节的高危青年中物质使用障碍的进展或停止
双胞胎/家庭研究设计以及了解合法获得大麻对
精神和行为结果。他计划扩大对生物标记物的搜索
以前利用分子遗传学进行的物质使用障碍
现在的方法包括蛋白质组学、代谢组学、RNA-SEQ和脂质组学方法。
Hopfer博士在多个研究培训领域指导受训人员,包括:1)理解
药物使用和滥用的临床方面,2)双胞胎/家庭和分子方法
检查物质使用和相关疾病的病因,3)准备科学论文
和提出调查结果,4)开发和撰写成功的项目提案,5)
进行负责任的研究。他将通过个人和个人完成他的训练任务
与具有生物统计学专业知识的关键同事进行小组指导和协作
用于识别物质使用的生物标志物的ART测量技术。
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Adolescents in Treatment for Substance Use Disorders: Callous-Unemotional Traits Moderate Associations Between Transdiagnostic Symptoms and Adolescent Suicidality.
治疗药物使用障碍的青少年:冷酷无情的特征跨诊断症状与青少年自杀之间的中度关联。
- DOI:10.1007/s10578-021-01256-w
- 发表时间:2023
- 期刊:
- 影响因子:2.9
- 作者:Winters,DrewE;Mikulich,SusanK;Hopfer,Christian;Sakai,JosephT
- 通讯作者:Sakai,JosephT
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{{ truncateString('Christian J Hopfer', 18)}}的其他基金
Effects of High Potency Cannabis Products on Mental Health and Psychosocial Functioning
高效大麻产品对心理健康和心理社会功能的影响
- 批准号:
10618709 - 财政年份:2023
- 资助金额:
$ 18.33万 - 项目类别:
Adult Progression of Adolescent Onset Substance Use Disorder in a High Risk Sample
高风险样本中青少年发作药物使用障碍的成人进展
- 批准号:
10677547 - 财政年份:2022
- 资助金额:
$ 18.33万 - 项目类别:
Adult Progression of Adolescent Onset Substance Use Disorder in a High Risk Sample
高风险样本中青少年发作药物使用障碍的成人进展
- 批准号:
10389730 - 财政年份:2022
- 资助金额:
$ 18.33万 - 项目类别:
Genetics and Progression of Early-onset Substance Dependence and HIV Risk
早发性物质依赖和艾滋病毒风险的遗传学和进展
- 批准号:
8693248 - 财政年份:2014
- 资助金额:
$ 18.33万 - 项目类别:
Mentoring Clinical Investigators in Adolescent-onset Substance Use Disorders Rese
指导临床研究人员进行青少年发作的药物使用障碍研究
- 批准号:
8639513 - 财政年份:2013
- 资助金额:
$ 18.33万 - 项目类别:
Mentoring Clinical Investigators in Adolescent-onset Substance Use Disorders Rese
指导临床研究人员进行青少年发作的药物使用障碍研究
- 批准号:
9228349 - 财政年份:2013
- 资助金额:
$ 18.33万 - 项目类别:
Mentoring Clinical Investigators in Adolescent-onset Substance Use Disorders Research
指导临床研究人员进行青少年发作的药物使用障碍研究
- 批准号:
10197062 - 财政年份:2013
- 资助金额:
$ 18.33万 - 项目类别:
Mentoring Clinical Investigators in Adolescent-onset Substance Use Disorders Rese
指导临床研究人员进行青少年发作的药物使用障碍研究
- 批准号:
8374081 - 财政年份:2013
- 资助金额:
$ 18.33万 - 项目类别:
Mentoring Clinical Investigators in Adolescent-onset Substance Use Disorders Rese
指导临床研究人员进行青少年发作的药物使用障碍研究
- 批准号:
8819525 - 财政年份:2013
- 资助金额:
$ 18.33万 - 项目类别:
Substance Use Disorder Research Training for Medical Students
医学生药物使用障碍研究培训
- 批准号:
8265532 - 财政年份:2012
- 资助金额:
$ 18.33万 - 项目类别:
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