A family study of substance use & coonduct disorder

描述(由申请人提供)：这是一项扩大对被判定患有物质使用障碍(SUD)和品行障碍(CD)的青少年男孩和女孩的家庭研究的建议。在这份修订后的申请中，我们建议评估通过法庭记录确定的400名青少年先证者的家庭，以及200名控制组及其家庭成员。将这项研究扩大到包括更多的家庭，将允许有足够的样本量来区分SUD和CD的不同共病模型，并评估父母和兄弟姐妹对SUD和CD的影响。DNA将被收集，以评估遗传相关程度和非亲子关系。该建议的具体目的是：1)在兄弟姐妹对中测试兄弟姐妹对中的SUD和CD共病模型，其中一个兄弟姐妹是被判定的青少年；2)在至少有一个被判定的青少年的家庭中，研究父母和兄弟姐妹对SUD和CD的发展的影响；以及3)比较被提议的样本和接受SUD和CD治疗的青年家庭样本中观察到的SUD和CD的家庭聚集。SUD和CD是严重的、危及生命的青春期疾病。据报道，这类青少年的死亡率是同龄人的五倍。这项研究可能导致对影响这些病理行为表达的家族影响的识别。这可能会导致表型的改善，改善对这些破坏性行为的特定遗传或环境原因的搜索。这项研究的最终目标是通过对这些病理、遗传或环境因素的治疗纠正来逆转这一过程。

DESCRIPTION (provided by applicant): This is a proposal to expand a family study of adjudicated adolescent boys and girls with Substance Use Disorders (SUD) and Conduct Disorder (CD). In this revised application, we propose to evaluate the families of 400 adolescent probands, identified through court records, as well as 200 controls and their family members. Expanding the study to include more families will allow for an adequate sample size to discriminate between different comorbidity models of SUD and CD and the assessment of parental and sibling influences on SUD and CD. DNA will be collected in order to assess for degree of genetic relatedness and non-paternity. The specific aims of the proposal are to: 1) test competing models of the comorbidity between SUD and CD in sibling pairs, where one of the siblings is an adjudicated adolescent, 2) examine the influence of parents and siblings on the development of SUD and CD in families with at least one adjudicated adolescent, and 3) compare the observed familial aggregation of SUD and CD between the proposed sample and a sample of families of youth in treatment for SUD and CD. SUD and CD are severe, life-threatening conditions of adolescence. Mortality rates among such adolescents reportedly are fivefold greater than among their age-mates. This research may lead to the identification of familial influences influencing the expression of these pathological behaviors. This may lead to improved phenotypes, improving the search for specific genetic or environmental causes of these destructive behaviors. The ultimate goal of this research is to reverse that process through therapeutic correction of those pathological genetic or environmental factors.