Mentoring Clinical Investigators in Adolescent-onset Substance Use Disorders Rese

描述（由申请人提供）：本职业生涯中期研究者奖申请寻求资金，以支持PI的研究生涯和指导活动。该奖项的资金将允许PI扩大他的指导活动，发展纵向的额外技能， 数据分析和扩展他的研究计划，包括了解病因学和纵向过程中的药物使用障碍。该奖项将导致从大量的行政和临床责任的救济作为成瘾，研究和治疗服务（ARTS），一个大型的治疗计划附属于科罗拉多丹佛安舒茨医学院大学的精神科主任。工作将转向指导活动、职业发展和研究活动。PI目前参与了许多研究，这些研究从临床、行为遗传学和分子遗传学的角度研究青少年和年轻成人的物质使用障碍。PI将通过扩大他目前的研究项目来扩大他的研究计划，以收集更多关于青少年对大麻使用的看法和模式的信息，并根据最近的“医用大麻”爆炸以及进行纵向研究，该研究将每6个月对临床和社区青少年进行一次抽样调查，为期3年，以检查大麻使用模式和相关HIV风险行为的发展。

DESCRIPTION (provided by applicant): This application for a mid-career investigator award seeks funds to support the PI's research career and mentoring activities. Funds from the award will allow the PI to expand his mentoring activities, develop additional skill sets in longitudinal data analysis and expand his program of research that involves understanding the etiology and longitudinal course of adolescent-onset substance use disorders. This award will result in relief from substantial administrative and clinical responsibilities as the Psychiatric Director of the Addiction, Research and Treatment Services (ARTS), a large treatment program affiliated with the University of Colorado Denver Anschutz Medical Campus. Effort will be redirected toward mentoring activities, career development, and research activities. The PI is currently involved in a number of studies that are examining adolescent and young adult substance use disorders, both from a clinical, behavior genetics, and molecular genetic perspective. The PI will expand his research program by expanding his current research projects to gather more information about adolescent perceptions and patterns of marijuana use in the light of the recent "medical marijuana" explosion as well as conduct a longitudinal study that will follow a sample of both clinical and community adolescents every 6 months for 3 years to examine the development of marijuana use patterns and associated HIV-risk behaviors.