Atlanta MACS/WIHS Combined Cohort Study Clinical Research Site

亚特兰大 MACS/WIHS 联合队列研究临床研究网站

• 批准号: 10214871
• 负责人: Ighovwerha Ofotokun
• 金额: $ 0.43万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10214871
• 关键词: Advisory Committees; Affect; Ancillary Study; Award; Biological; Career Mobility; Caring; Clinic; Clinical; Clinical Research; Cohort Studies; Communities; Community Outreach; Consent; Data; Databases; Development; Enrollment; Environment; Epidemic; Event; Faculty; Fostering; Foundations; Funding; Funding Agency; Goals; Growth; HIV; HIV Seronegativity; HIV Seropositivity; HIV diagnosis; Health; Home environment; Individual; K-Series Research Career Programs; Laboratory Study; Lead; Leadership; Link; Location; Mediation; Mentorship; Minority Groups; Operations Research; Participant; Pathogenesis; Patients; Pharmacologic Substance; Population Heterogeneity; Principal Investigator; Procedures; Productivity; Protocols documentation; Publications; Quality Control; Reading; Research; Research Activity; Research Infrastructure; Research Personnel; Resources; Risk; Role; Rural; SECTM1 gene; Science; Scientist; Site; Specimen; Structure; Training; Underrepresented Minority; United States National Institutes of Health; Visit; Woman; adjudication; age related; base; career development; clinical research site; cohort; comorbidity; data quality; disease registry; good laboratory practice; health disparity; innovative technologies; men; men who have sex with men; multidisciplinary; next generation; programs; recruit; volunteer

Abstract The overarching goal of the Atlanta Clinical Research Site (CRS) is to advance the unified scientific agenda of the MACS/WIHS CCS by: a) providing leadership in the development of the unified science protocols; b) serving as a local reading center and support laboratory for studies; and c) leveraging our research infrastructure to implement the CCS protocols by retaining current participants, recruiting new participants from under-represented minority groups, and engaging Emory scientists and the local community in CCS science and activities. The Atlanta CRS is well poised to accomplish these goals because of our unique location at the epicenter of the U.S. epidemic, the robustness of our HIV research program, and our track record of successful and collaborative contribution to the unified science of the WIHS over the past 5 years. Georgia now has the third highest rate of new HIV diagnoses among the Southern states1 and the 5th largest HIV epidemic among the U.S. states2. While HIV rates are high in both rural and urban Georgia, Atlanta is home to most (62%) of the state’s affected patients, and the majority reside within 10 miles of the Atlanta CRS. Importantly, nearly two-thirds of people living with HIV in Atlanta and ~20% in Georgia receive care in Emory associated HIV clinics (n=10,354). HIV+ and negative volunteers that have consented to be contacted for research are available via the CFAR HIV Disease Registry (> 13,000 unique patients), the PRISM Health MSM cohorts led by Emory faculty Dr. Patrick Sullivan, and the Georgia CTSA database (>100,000 individuals), providing us access to a diverse population of HIV+ and at-risk HIV- individuals from across the state. Leveraging these institutional resources, the Atlanta CRS will contribute to the CCS unified science in the following manner: 1) Provide leadership to support the CCS unified specific aims through expert contribution by Emory investigators, including scientific specific leadership roles in the following aims: (a) age related co- morbidities; (b) health disparities; (c) HIV pathogenesis; and (d) career development; 2) Leverage our state-of- the-art research infrastructure to implement all components of the CCS unified science, including adjudication of clinical events, development of data quality control procedures and good laboratory practices, staff training in relevant CCS research activities, and enrollment of new participants; 3) Enhance our vibrant community engagement to support our efforts to enroll new participants, expand our CAB to be representative of the combined cohort of women and men, and introduce use of innovative technology to enhance community outreach and support accrual and engagement of our combined cohort; and 4) Build on our track record of mentorship by expanding HIV research opportunities for early stage investigators in coordination with the CCS Investigator Developmental Award Advisory Committee.

抽象的 亚特兰大临床研究地点（CRS）的总体目标是促进统一的科学Agernda Mac/WIHS CCS通过：a）在制定统一科学协议的发展方面； b） 担任当地阅读中心并支持研究实验室； c）利用我们的研究 通过保留当前参与者，从 代表性不足的少数群体，吸引埃默里科学家和当地社区CCS科学 和活动。亚特兰大CRS有毒，可以实现这些目标 美国流行病的中心，我们的艾滋病毒研究计划的鲁棒性以及我们成功的记录 在过去5年中，对WIHS统一科学的合作贡献。 佐治亚州现在在南部州的新艾滋病毒诊断的第三高，第五大诊断。 美国国家的艾滋病毒流行2。虽然乔治亚州的艾滋病毒率高，但亚特兰大是 该州大多数受影响的患者的所在地（62％）居住在亚特兰大CRS的10英里范围内。 重要的是，在亚特兰大，近三分之二的艾滋病毒感染者和乔治亚州约有20％在埃默里接受护理 相关的HIV诊所（n = 10,354）。艾滋病毒+和负面志愿者已同意联系 可通过CFAR HIV疾病注册中心（> 13,000名独特患者）进行研究，Prism Health MSM 由埃默里（Emory）教师帕特里克·沙利文（Patrick Sullivan）博士和佐治亚州CTSA数据库（> 100,000个人）领导的同伙， 使我们能够获得来自全州的艾滋病毒+和高危艾滋病毒的多样性人群。 利用这些机构资源，亚特兰大CRS将为CCS统一科学做出贡献 以下方式：1）提供领导才能通过专家的贡献来支持CCS统一特定目标 Emory的调查人员，包括以下目的包括科学特定的领导角色：（a）与年龄相关的共同 病毒； （b）健康差异； （c）HIV发病机理； （d）职业发展； 2）利用我们的最新 ART研究基础设施以实施CCS统一科学的所有组成部分，包括裁决 临床活动，数据质量控制程序的开发和良好的实验室实践，员工培训 在相关的CCS研究活动和新参与者的招生中； 3）增强我们充满活力的社区 参与以支持我们为入学新参与者的努力，扩展我们的出租车以代表 男女组合组合，并引入创新技术来增强社区 宣传和支持我们组合队列的准确性和参与度； 4）建立在我们的往绩上 通过扩大与CCS协调的早期研究人员的艾滋病毒研究机会，通过扩大艾滋病毒研究机会 研究者发展奖咨询委员会。