Atlanta MACS/WIHS Combined Cohort Study Clinical Research Site

亚特兰大 MACS/WIHS 联合队列研究临床研究网站

• 批准号: 10214871
• 负责人: Ighovwerha Ofotokun
• 金额: $ 0.43万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10214871
• 关键词: Advisory Committees; Affect; Ancillary Study; Award; Biological; Career Mobility; Caring; Clinic; Clinical; Clinical Research; Cohort Studies; Communities; Community Outreach; Consent; Data; Databases; Development; Enrollment; Environment; Epidemic; Event; Faculty; Fostering; Foundations; Funding; Funding Agency; Goals; Growth; HIV; HIV Seronegativity; HIV Seropositivity; HIV diagnosis; Health; Home environment; Individual; K-Series Research Career Programs; Laboratory Study; Lead; Leadership; Link; Location; Mediation; Mentorship; Minority Groups; Operations Research; Participant; Pathogenesis; Patients; Pharmacologic Substance; Population Heterogeneity; Principal Investigator; Procedures; Productivity; Protocols documentation; Publications; Quality Control; Reading; Research; Research Activity; Research Infrastructure; Research Personnel; Resources; Risk; Role; Rural; SECTM1 gene; Science; Scientist; Site; Specimen; Structure; Training; Underrepresented Minority; United States National Institutes of Health; Visit; Woman; adjudication; age related; base; career development; clinical research site; cohort; comorbidity; data quality; disease registry; good laboratory practice; health disparity; innovative technologies; men; men who have sex with men; multidisciplinary; next generation; programs; recruit; volunteer

Abstract The overarching goal of the Atlanta Clinical Research Site (CRS) is to advance the unified scientific agenda of the MACS/WIHS CCS by: a) providing leadership in the development of the unified science protocols; b) serving as a local reading center and support laboratory for studies; and c) leveraging our research infrastructure to implement the CCS protocols by retaining current participants, recruiting new participants from under-represented minority groups, and engaging Emory scientists and the local community in CCS science and activities. The Atlanta CRS is well poised to accomplish these goals because of our unique location at the epicenter of the U.S. epidemic, the robustness of our HIV research program, and our track record of successful and collaborative contribution to the unified science of the WIHS over the past 5 years. Georgia now has the third highest rate of new HIV diagnoses among the Southern states1 and the 5th largest HIV epidemic among the U.S. states2. While HIV rates are high in both rural and urban Georgia, Atlanta is home to most (62%) of the state’s affected patients, and the majority reside within 10 miles of the Atlanta CRS. Importantly, nearly two-thirds of people living with HIV in Atlanta and ~20% in Georgia receive care in Emory associated HIV clinics (n=10,354). HIV+ and negative volunteers that have consented to be contacted for research are available via the CFAR HIV Disease Registry (> 13,000 unique patients), the PRISM Health MSM cohorts led by Emory faculty Dr. Patrick Sullivan, and the Georgia CTSA database (>100,000 individuals), providing us access to a diverse population of HIV+ and at-risk HIV- individuals from across the state. Leveraging these institutional resources, the Atlanta CRS will contribute to the CCS unified science in the following manner: 1) Provide leadership to support the CCS unified specific aims through expert contribution by Emory investigators, including scientific specific leadership roles in the following aims: (a) age related co- morbidities; (b) health disparities; (c) HIV pathogenesis; and (d) career development; 2) Leverage our state-of- the-art research infrastructure to implement all components of the CCS unified science, including adjudication of clinical events, development of data quality control procedures and good laboratory practices, staff training in relevant CCS research activities, and enrollment of new participants; 3) Enhance our vibrant community engagement to support our efforts to enroll new participants, expand our CAB to be representative of the combined cohort of women and men, and introduce use of innovative technology to enhance community outreach and support accrual and engagement of our combined cohort; and 4) Build on our track record of mentorship by expanding HIV research opportunities for early stage investigators in coordination with the CCS Investigator Developmental Award Advisory Committee.

摘要