COVID Vaccine Study OAR Supplement to MWCCS

项目总结/摘要 MWCCS参与者是严重COVID-19疾病的高风险群体，因为他们感染了艾滋病毒， 主要是老年人，并有许多潜在的合并症。因此，他们必须 新冠肺炎疫苗的接种。然而，迄今为止， 关于COVID-19疫苗在艾滋病毒感染者中的接受程度和有效性的数据。MWCCS是理想的 分析（a）新型冠状病毒疫苗在男性和女性威尔斯亲王医院及配对的爱滋病病毒感染者中的接受程度和效果- 未感染对照组（HUC），（B）年龄和合并症对疫苗免疫应答和保护的影响 以及（c）COVID-19免疫接种后的社会、经济和行为变化， 与那些选择不接种疫苗的人相比。为了解决这个问题，我们将有两组 本研究的MWCCS参与者：A组：选择接受COVID-1治疗的男性和女性PWH和HUC 19疫苗，B组：选择不接种COVID-19疫苗的男女PWH和HUC。

Project Summary/Abstract MWCCS participants are a high-risk group for severe COVID-19 disease in terms of being HIV-infected, predominately of elderly age, and having numerous underlying comorbidities. Therefore, it is imperative for their health that they be vaccinated with the new COVID-19 vaccines. To date, however, there are only anecdotal data on COVID-19 vaccine acceptance and efficacy in people with HIV (PWH). The MWCCS is ideal for analyzing (a) the acceptancy and effects of COVID-19 vaccine(s) in male and female PWH and matched HIV- uninfected controls (HUC), (b) the impact of age and co-morbidities on vaccine immune response and protection against COVID-19, and (c) the social, economic, and behavioral changes after COVID-19 immunization as compared to the individuals who opted to not take the vaccine. To address this issue, we will have 2 groups of MWCCS participants in this study: Group A: Male and female PWH and HUC who choose to receive a COVID- 19 vaccine, Group B: Male and female PWH and HUC who choose NOT to receive a COVID-19 vaccine.