COVID Vaccine Study OAR Supplement to MWCCS

COVID 疫苗研究 OAR 对 MWCCS 的补充

• 批准号: 10389426
• 负责人: Ighovwerha Ofotokun
• 金额: $ 3.44万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10389426
• 关键词: 2019-nCoV; Address; Age; Behavioral; COVID-19; COVID-19 vaccine; Clinical; Cohort Studies; Data; Disease; Economics; Elderly; Female; HIV; Health; Immune response; Immunization; Incidence; Individual; Longitudinal observational study; Methods; Monitor; Participant; Prevalence; Protocols documentation; SARS-CoV-2 infection; Serology; Specimen; Trust; Vaccinated; Vaccination; Vaccines; base; comorbidity; coronavirus disease; design; high risk population; innovation; male; response; severe COVID-19; social; vaccine acceptance; vaccine efficacy; vaccine hesitancy; vaccine trial

Project Summary/Abstract MWCCS participants are a high-risk group for severe COVID-19 disease in terms of being HIV-infected, predominately of elderly age, and having numerous underlying comorbidities. Therefore, it is imperative for their health that they be vaccinated with the new COVID-19 vaccines. To date, however, there are only anecdotal data on COVID-19 vaccine acceptance and efficacy in people with HIV (PWH). The MWCCS is ideal for analyzing (a) the acceptancy and effects of COVID-19 vaccine(s) in male and female PWH and matched HIV- uninfected controls (HUC), (b) the impact of age and co-morbidities on vaccine immune response and protection against COVID-19, and (c) the social, economic, and behavioral changes after COVID-19 immunization as compared to the individuals who opted to not take the vaccine. To address this issue, we will have 2 groups of MWCCS participants in this study: Group A: Male and female PWH and HUC who choose to receive a COVID- 19 vaccine, Group B: Male and female PWH and HUC who choose NOT to receive a COVID-19 vaccine.

项目摘要/摘要 就感染艾滋病毒而言，MWCCS参与者是严重新冠肺炎疾病的高危人群， 主要是老年人，并有许多潜在的合并症。因此，他们势在必行 他们接种了新的新冠肺炎疫苗，这对他们的健康至关重要。然而，到目前为止，只有轶事 有关艾滋病病毒感染者(PWH)对新冠肺炎疫苗接受度和疗效的数据。MWCCS非常适合 分析(A)新冠肺炎疫苗(S)在男女特发性肝炎和配型HIV感染者中的接受性和效果 未感染对照(HUC)，(B)年龄和合并症对疫苗免疫反应和保护的影响 (C)新冠肺炎接种后的社会、经济和行为变化，如 与选择不接种疫苗的人相比。为了解决这个问题，我们将有两个小组， 本研究的MWCCS参与者：A组：选择接受COVID的男性和女性PWH和HUC- 19疫苗，B组：选择不接种新冠肺炎疫苗的男性和女性威尔斯亲王和胡克。