Atlanta MACS/WIHS Combined Cohort Study Clinical Research Site

摘要 亚特兰大临床研究中心(CRS)的首要目标是推进 MACS/WIHS CCS：a)领导制定统一的科学协议；b) 作为当地的阅读中心和研究支持实验室；以及c)利用我们的研究 实施CCS协议的基础设施，方法是保留现有参与者，从 代表不足的少数群体，并让埃默里的科学家和当地社区参与CCS科学 和活动。亚特兰大CRS已经做好了实现这些目标的准备，因为我们位于 美国疫情的震中，我们艾滋病毒研究计划的健壮性，以及我们成功的记录 在过去的5年里，为WIHS的统一科学做出了合作贡献。 格鲁吉亚现在的艾滋病毒新诊断率在南部各州中排名第三，在第五大州中排名第五 艾滋病毒在美国各州的流行2。虽然佐治亚州农村和城市的艾滋病毒感染率都很高，但亚特兰大 该州大多数(62%)受影响患者的家园，大多数人居住在亚特兰大CRS 10英里以内。 重要的是，亚特兰大近三分之二的艾滋病毒携带者和佐治亚州约20%的艾滋病毒携带者在埃默里接受治疗 与艾滋病毒有关的诊所(n=10,354)。HIV阳性和阴性志愿者同意被联系 这项研究可通过CFAR艾滋病毒疾病登记处(13,000名独特患者)、PRISM Health MSM获得 由埃默里教员帕特里克·沙利文博士领导的队列，以及佐治亚州CTSA数据库(&gt；10万人)， 为我们提供接触到全州不同人群的艾滋病毒阳性和高危艾滋病毒个人的机会。 利用这些机构资源，亚特兰大CRS将为CCS在 以下方式：1)通过专家的贡献，领导支持CCS统一的具体目标 埃默里调查人员，包括在以下目标中发挥科学具体领导作用：(A)与年龄有关的共同 疾病；(B)健康差距；(C)艾滋病毒的致病机制；和(D)职业发展；2)利用我们的 最先进的研究基础设施，以实施CCS统一科学的所有组件，包括裁决 临床事件、数据质量控制程序和良好实验室实践的发展、工作人员培训 参与相关的CCS研究活动，并招募新的参与者；3)增强我们充满活力的社区 参与支持我们招收新参与者的努力，将我们的CAB扩展为代表 结合男女队列，并引入创新技术来加强社区 我们合并队列的外联和支持积累和参与；以及4)建立在我们在以下方面的记录基础上 通过与CCS协调为早期研究人员扩大艾滋病毒研究机会进行指导 调查员发展奖咨询委员会。

Abstract The overarching goal of the Atlanta Clinical Research Site (CRS) is to advance the unified scientific agenda of the MACS/WIHS CCS by: a) providing leadership in the development of the unified science protocols; b) serving as a local reading center and support laboratory for studies; and c) leveraging our research infrastructure to implement the CCS protocols by retaining current participants, recruiting new participants from under-represented minority groups, and engaging Emory scientists and the local community in CCS science and activities. The Atlanta CRS is well poised to accomplish these goals because of our unique location at the epicenter of the U.S. epidemic, the robustness of our HIV research program, and our track record of successful and collaborative contribution to the unified science of the WIHS over the past 5 years. Georgia now has the third highest rate of new HIV diagnoses among the Southern states1 and the 5th largest HIV epidemic among the U.S. states2. While HIV rates are high in both rural and urban Georgia, Atlanta is home to most (62%) of the state’s affected patients, and the majority reside within 10 miles of the Atlanta CRS. Importantly, nearly two-thirds of people living with HIV in Atlanta and ~20% in Georgia receive care in Emory associated HIV clinics (n=10,354). HIV+ and negative volunteers that have consented to be contacted for research are available via the CFAR HIV Disease Registry (> 13,000 unique patients), the PRISM Health MSM cohorts led by Emory faculty Dr. Patrick Sullivan, and the Georgia CTSA database (>100,000 individuals), providing us access to a diverse population of HIV+ and at-risk HIV- individuals from across the state. Leveraging these institutional resources, the Atlanta CRS will contribute to the CCS unified science in the following manner: 1) Provide leadership to support the CCS unified specific aims through expert contribution by Emory investigators, including scientific specific leadership roles in the following aims: (a) age related co- morbidities; (b) health disparities; (c) HIV pathogenesis; and (d) career development; 2) Leverage our state-of- the-art research infrastructure to implement all components of the CCS unified science, including adjudication of clinical events, development of data quality control procedures and good laboratory practices, staff training in relevant CCS research activities, and enrollment of new participants; 3) Enhance our vibrant community engagement to support our efforts to enroll new participants, expand our CAB to be representative of the combined cohort of women and men, and introduce use of innovative technology to enhance community outreach and support accrual and engagement of our combined cohort; and 4) Build on our track record of mentorship by expanding HIV research opportunities for early stage investigators in coordination with the CCS Investigator Developmental Award Advisory Committee.