Atlanta MACS/WIHS Combined Cohort Study Clinical Research Site

亚特兰大 MACS/WIHS 联合队列研究临床研究网站

• 批准号: 10612742
• 负责人: Ighovwerha Ofotokun
• 金额: $ 303.41万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10612742
• 关键词: Advisory Committees; Affect; Ancillary Study; Award; Biological; Career Mobility; Caring; Clinic; Clinical; Clinical Research; Cohort Studies; Communities; Community Outreach; Consent; Data; Databases; Dedications; Development; Enrollment; Environment; Epidemic; Event; Faculty; Fostering; Foundations; Funding; Funding Agency; Goals; Growth; HIV; HIV Seropositivity; HIV diagnosis; Health; Home; Individual; Institution; K-Series Research Career Programs; Laboratory Study; Lead; Leadership; Link; Location; Mediation; Mentored Clinical Scientist Development Program; Mentorship; Minority Groups; Participant; Pathogenesis; Patients; Persons; Pharmacologic Substance; Population Heterogeneity; Principal Investigator; Procedures; Productivity; Protocols documentation; Publications; Quality Control; Reading; Research; Research Activity; Research Infrastructure; Research Personnel; Resources; Risk; Role; Rural; Science; Scientist; Site; Specimen; Structure; Training; Underrepresented Minority; United States National Institutes of Health; Visit; Woman; adjudication; age related; base; career development; clinical research site; cohort; community engagement; comorbidity; data quality; disease registry; good laboratory practice; health disparity; innovative technologies; men; men who have sex with men; multidisciplinary; next generation; operation; programs; recruit; volunteer

Abstract The overarching goal of the Atlanta Clinical Research Site (CRS) is to advance the unified scientific agenda of the MACS/WIHS CCS by: a) providing leadership in the development of the unified science protocols; b) serving as a local reading center and support laboratory for studies; and c) leveraging our research infrastructure to implement the CCS protocols by retaining current participants, recruiting new participants from under-represented minority groups, and engaging Emory scientists and the local community in CCS science and activities. The Atlanta CRS is well poised to accomplish these goals because of our unique location at the epicenter of the U.S. epidemic, the robustness of our HIV research program, and our track record of successful and collaborative contribution to the unified science of the WIHS over the past 5 years. Georgia now has the third highest rate of new HIV diagnoses among the Southern states1 and the 5th largest HIV epidemic among the U.S. states2. While HIV rates are high in both rural and urban Georgia, Atlanta is home to most (62%) of the state’s affected patients, and the majority reside within 10 miles of the Atlanta CRS. Importantly, nearly two-thirds of people living with HIV in Atlanta and ~20% in Georgia receive care in Emory associated HIV clinics (n=10,354). HIV+ and negative volunteers that have consented to be contacted for research are available via the CFAR HIV Disease Registry (> 13,000 unique patients), the PRISM Health MSM cohorts led by Emory faculty Dr. Patrick Sullivan, and the Georgia CTSA database (>100,000 individuals), providing us access to a diverse population of HIV+ and at-risk HIV- individuals from across the state. Leveraging these institutional resources, the Atlanta CRS will contribute to the CCS unified science in the following manner: 1) Provide leadership to support the CCS unified specific aims through expert contribution by Emory investigators, including scientific specific leadership roles in the following aims: (a) age related co- morbidities; (b) health disparities; (c) HIV pathogenesis; and (d) career development; 2) Leverage our state-of- the-art research infrastructure to implement all components of the CCS unified science, including adjudication of clinical events, development of data quality control procedures and good laboratory practices, staff training in relevant CCS research activities, and enrollment of new participants; 3) Enhance our vibrant community engagement to support our efforts to enroll new participants, expand our CAB to be representative of the combined cohort of women and men, and introduce use of innovative technology to enhance community outreach and support accrual and engagement of our combined cohort; and 4) Build on our track record of mentorship by expanding HIV research opportunities for early stage investigators in coordination with the CCS Investigator Developmental Award Advisory Committee.

摘要 亚特兰大临床研究中心（CRS）的总体目标是推进统一的科学议程， MACS/WIHS CCS：a）在制定统一科学协议方面发挥领导作用; B） 作为当地的阅读中心和研究支持实验室;以及c）利用我们的研究 通过保留现有参与者，从其他国家招募新的参与者， 代表性不足的少数群体，并让埃默里大学的科学家和当地社区参与CCS科学 和活动.亚特兰大CRS是做好准备，以实现这些目标，因为我们独特的位置， 我们的艾滋病研究计划的稳健性，以及我们成功的 在过去的5年里，WIHS的统一科学的合作贡献。 格鲁吉亚现在的艾滋病毒新诊断率在南方各州中排名第三1，在全国各州中排名第五 艾滋病在美国各州的流行2.尽管格鲁吉亚的农村和城市艾滋病毒感染率都很高，但亚特兰大是 亚特兰大是该州大多数（62%）受影响患者的家园，大多数人居住在亚特兰大CRS的10英里范围内。 重要的是，亚特兰大近三分之二的艾滋病毒感染者和格鲁吉亚约20%的艾滋病毒感染者在埃默里接受治疗 相关艾滋病毒诊所（n= 10 354）。已同意联系的HIV阳性和阴性志愿者 研究可通过CFAR HIV疾病登记处（> 13，000名独特患者），PRISM Health MSM 由埃默里大学教师帕特里克沙利文博士和格鲁吉亚CTSA数据库（> 10万人）领导的队列， 为我们提供了接触来自全州的各种艾滋病毒+和艾滋病毒高危人群的机会。 利用这些机构资源，亚特兰大CRS将为CCS统一科学做出贡献， （1）通过专家贡献发挥领导作用，支持综合传播战略的统一具体目标， 埃默里大学的研究人员，包括科学的具体领导作用，在以下目标：（a）年龄相关的共同， 发病率;（B）健康差距;（c）艾滋病毒发病机制;（d）职业发展; 2）利用我们的 最先进的研究基础设施，以实施CCS统一科学的所有组成部分，包括裁定 临床事件、数据质量控制程序和药物非临床研究质量管理规范的制定、工作人员培训 3）加强社区的活力 参与，以支持我们努力招募新的参与者，扩大我们的CAB，以代表 妇女和男子的混合队列，并引入使用创新技术，以提高社区 外展和支持我们的合并队列的累积和参与;和4）建立在我们的跟踪记录， 通过与CCS协调，为早期研究人员扩大艾滋病毒研究机会， 研究者发展奖咨询委员会。