Administration Core

项目摘要/摘要--行政核心(AC) 以URI为主导的PFAS超级基金研究项目的来源、运输、暴露和影响 (SRP)中心专注于创新研究，以确定：新兴的多氟和全氟 饮用水中的烷基物质(PFAS)(科德角研究地点)；当前联邦法规的适用性 标准；不良健康影响的重要性，例如免疫功能障碍和代谢异常 在早期发展期间以及可能在更远的地方(法罗群岛)；易受健康影响的预测因素； 开发新的检测工具(被动取样器)，以测试前体和 地下水和私人水井中全氟辛烷磺酸的浓度；存在全氟辛烷磺酸的影响 在人类、食物网和环境中的生物积累；受影响社区的参与 全氟辛烷磺酸的存在和危险；以及通过州、地区、国家和 国际利益攸关方。 START II行政核心(AC)将通过以下方式继续成功运作START SRP中心 综合内部咨询委员会和外部咨询委员会的咨询意见 通过定期务虚会和与陡峭团队的联合视频通话。在高级协调员的监督下， 协调能力，AC将在财务、报告要求、 补充资金、数据管理、任务和目标。咨询委员会将进一步促进核心的整合 通过领导和组织核心和项目交叉会议、讲习班、务虚会、 以及为陡峭团队举办的研讨会。 作为主办机构，URI将继续致力于陡峭中心的成功，并承诺每个 除教学外，每年用于陡峭二期的业务，包括陡峭协调员的报酬 救济和资助另外两个少数族裔研究生助学金。AC研究翻译团队将 继续发挥其核心和良好整合的作用，联系内部陡峭的研究人员，以促进定期 通过以协调和跨学科的方式努力实现目标来进行沟通和协作 延伸至参与机构。除了与SRP中心外部的相关方共享数据外， START II AC的一个主要目标是促进项目之间和项目之间的数据和知识共享 核心。咨询委员会将通过以下目标确保陡峭II中心的成功： 具体目标1：确保有效整合第二阶段的项目和中心 具体目标2：为陡峭II的任务和目标提供领导 具体目标3：确保陡峭II提供相关和及时的研究、翻译、技术 以及为利益相关者和社区提供的工具 具体目标4：确定新的利益攸关方和协作者并与之合作

PROJECT SUMMARY/ABSTRACT – ADMINISTRATIVE CORE (AC) The URI-led Sources, Transport, Exposure, and Effects of PFAS (STEEP) Superfund Research Program (SRP) Center is focused on innovative research to determine: the ubiquity of emerging poly- and perfluorinated alkyl substances (PFAS) in drinking water (Cape Cod study site); the suitability of current federal regulatory standards; the significance of adverse health impacts, e.g., immune dysfunction and metabolic abnormalities during early development and possibly beyond (Faroe Islands); the predictors of vulnerability to health impacts; the development of novel detection tools (passive samplers) to test for the presence of precursors and concentrations of PFAS in groundwater and private wells; the implications of the presence of PFAS with regard to bioaccumulation in humans, the food web, and the environment; the engagement of affected communities with the presence and dangers of PFAS; and the dissemination of findings through state, regional, national, and international stakeholders. The STEEP II Administrative Core (AC) will continue its successful operation of the STEEP SRP Center by integrating advice from both the Internal Advisory Committee (IAC) and the External Advisory Committee (EAC) through regular retreats and joint video calls with the STEEP team. With the STEEP Coordinator's oversight and coordination skills, the AC will keep STEEP on target with respect to finances, reporting requirements, supplemental funding, data management, mission, and aims. The AC will further foster the integration of cores and projects by leading and organizing core and project specific cross-cutting meetings, workshops, retreats, and seminars for the STEEP team. As host institution, URI remains committed to the success of the STEEP Center and pledges $100k per annum toward STEEP II’s operation, including the STEEP Coordinator’s compensation, in addition to teaching relief and funding two additional minority graduate student assistantships. The AC research translation team will continue to serve in its central and well-integrated role of connecting intra-STEEP researchers to promote regular communication and collaboration by working toward goals in a coordinated and interdisciplinary manner that extends to the participating institutions. Beyond sharing data with interested parties external to the SRP Center, a main goal of the STEEP II AC is facilitating data and knowledge-sharing between and among projects and cores. The AC will ensure the success of the STEEP II Center through the following Aims: Specific Aim 1: Ensure the efficient integration of STEEP II's projects and centers Specific Aim 2: Provide leadership for STEEP II's mission and goals Specific Aim 3: Ensure that STEEP II provides relevant and timely research translation, technology transfer, and tools for stakeholders and communities Specific Aim 4: Identify and work with new stakeholders and collaborators