Res-Ed-Component

研究教育核心摘要 美国有超过500万人患有阿尔茨海默病或相关痴呆症（ADRD）。近期数据显示 ADRD导致的死亡率正在飙升，特别是在美国印第安人和阿拉斯加原住民中， (AI/AN），其中ADRD死亡率在1999年至2014年间上升了80%。无特定人群估计数 夏威夷原住民或太平洋岛民（NHPIs）的ADRD死亡率，但 同期，夏威夷增长了59%。然而，AI/AN和NHPI参与者很少被纳入ADRD 研究，尽管预期寿命显著增加。此外，由于很少有AI/AN或NHPI科学家 进行ADRD研究，这一研究领域没有从独特的“内幕”观点中获益， 研究人员会提供。这个本土阿尔茨海默病相关资源中心在少数民族老龄化的目标 研究（NAD-RCMAR）是建立研究能力，提高专业劳动力的多样性， 培育创新的社会科学，行为和经济研究ADRD。的科学重点 研究教育部分将是AI/AN和NHPI中与ADRD相关的人口水平健康差异， 包括行为、社会文化和环境因素，以健康差异研究为基础 NIA认可的框架。参与试点研究的每个NAD-RCMAR科学家都将有一个指导团队 包括一名生物统计学家，一名成功的代表性不足的少数民族（URM）研究人员和一名资深科学家。 另一个关键组成部分将是关于ADRD，研究方法，健康差距和少数民族老龄化的培训。 这些综合活动将帮助NAD-RCMAR科学家获得外部资金，如K和K的赠款， R 01系列。我们将与科罗拉多大学和斯坦福大学的研究人员合作， 我们的成功和经验教训，在过去20年来，通过我们目前资助的RCMAR，本土 长者研究中心。我们也将受益于我们正在进行的合作与领导3阿尔茨海默氏症 疾病中心和积极征求试点申请从AI/AN，NHPI，和其他URM调查。我们 具体目标是：1）提供财政、后勤和科学资源，以支持ADRD的试点研究 在AI/AN或NHPI社区中，以生成初步的人口水平数据，用于随后的拨款 2）增加能够进行ADRD研究的AI/AN和NHPI专业人员的数量; 3)发起并维持高级研究人员和NAD-RCMAR科学家之间的指导关系; 4） 通过参与试点研究提高NAD-RCMAR科学家的方法技能， 教育会议;和5）在高影响力期刊上发表试点研究的结果。NIA领导层表示， AI/AN和其他URM是ADRD研究的优先人群。NAD-RCMAR将促进 参与试点研究，同时让NAD-RCMAR科学家参与职业培训和研究 这些活动将使他们成为独立调查员，并丰富这一调查领域。

RESEARCH EDUCATION CORE ABSTRACT More than 5 million people in the US have Alzheimer’s disease or related dementias (ADRD). Recent data show that rates of mortality attributable to ADRD are soaring, especially among American Indians and Alaska Natives (AI/AN), among whom ADRD mortality rose by 80% between 1999 and 2014. No population-specific estimates are available for Native Hawaiians or Pacific Islanders (NHPIs), but ADRD mortality in the general population of Hawaii increased by 59% over the same period. Yet, AI/AN and NHPI participants are rarely included in ADRD research, despite striking increases in life expectancy. Furthermore, because very few AI/AN or NHPI scientists conduct ADRD research, this field of study receives no benefit from the unique “insider” perspectives that such researchers would offer. The goal of this Native Alzheimer’s Disease-related Resource Center in Minority Aging Research (NAD-RCMAR) is to build research capacity, enhance diversity in the professional workforce, and nurture innovative social science, behavioral, and economic research on ADRD. The scientific focus of the Research Education Component will be population-level health disparities related to ADRD in AI/ANs and NHPIs, including behavioral, sociocultural, and environmental factors, grounded in the health disparities research framework endorsed by NIA. Each NAD-RCMAR Scientist engaged in a Pilot Study will have a mentoring team comprising a biostatistician, a successful underrepresented minority (URM) researcher, and a senior scientist. Another key component will be training on ADRD, research methods, health disparities, and minority aging. These integrated activities will help NAD-RCMAR Scientists obtain external funding, such as grants in the K and R01 series. We will partner with researchers at the University of Colorado and Stanford University and leverage our successes and lessons learned over the past 20 years through our currently funded RCMAR, the Native Elder Research Center. We will also benefit from our ongoing collaborations with the leadership of 3 Alzheimer’s Disease Centers and actively solicit pilot applications from AI/AN, NHPI, and other URM investigators. Our Specific Aims are to: 1) Offer financial, logistical, and scientific resources to support Pilot Studies on ADRD among AI/AN or NHPI communities in order to generate preliminary population-level data for subsequent grant applications; 2) Increase the number of AI/AN and NHPI professionals capable of conducting ADRD research; 3) Initiate and maintain mentoring relationships between senior researchers and NAD-RCMAR Scientists; 4) Improve the methodological skills of NAD-RCMAR Scientists through their participation in Pilot Studies and educational sessions; and 5) Publish findings of Pilot Studies in high-impact journals. NIA leadership has stated that AI/ANs and other URMs are priority populations to include in ADRD research. NAD-RCMAR will promote their participation in Pilot Studies while engaging NAD-RCMAR Scientists in career training and research activities that will prepare them to become independent investigators and enrich this field of inquiry.