Native Alzheimer Disease Resource Center for Minority Aging Research (NAD-RCMAR)

摘要-研究教育组成部分 美国有600多万人患有阿尔茨海默病或相关痴呆症(ADRD)。现存的 文献表明，在种族和少数民族中，特别是美国人，患ADRD的风险更高 印第安人和阿拉斯加原住民(AI/AN)和夏威夷土著或太平洋岛民(NHPI)。不幸的是，有一个 在土著人民中缺乏对ADRD的批判性研究。利用MESH检索PubMed数据库 “阿尔茨海默氏症”和“美洲印第安人或阿拉斯加原住民”这两个词只检索了32篇相关出版物，而 对NHPI的平行搜索仅返回19种出版物。AI/ANS和NHPI在 NIA资助的阿尔茨海默病研究中心计划，在37个国家中，45,923人中只有454人参加 中心在过去17年中主要识别为AI/AN或NHPI。因为这些中心的数据 导致一些最有影响力的ADRD研究，AI/AN和NHPI参与者的代表性较差 他们对研究结果、医疗政策或临床治疗标准的贡献有限。 此外，由于很少有AI/AN或NHPI科学家进行ADRD研究。原住民的目标 少数民族老龄化研究中的阿尔茨海默病资源中心(NAD-RCMAR)是为了建设研究能力， 增强专业劳动力的多样性，培养创新的社会、行为、流行病学和 ADRD的临床研究。研究教育部分(REC)的科学重点将是健康 通过关注发生的可改变的风险和复原力因素，在AI/ANS和NHPI中与ADRD相关的差异 在中老年，这都会增加ADRD的风险，并且与AI/AN和NHPI社区高度相关。 REC将通过指导有前途的NAD-RCMAR来加强ADRD研究人员的多样性 科学家，特别是来自代表不足的少数群体(URM)的科学家，专注于AI/ANS和NHPI。区域经济共同体 将为NAD-RCMAR科学家为我们的试点研究提供研究设计和测量方面的支持，并将提供 一个以非常成功的授权为蓝本的研讨会：最大化战略，帮助， 机会，体验(口香糖)计划。我们的具体目标是：(1)提供后勤、科学 支持人工智能/ANS和NHPI中关于ADRD的创新试点研究的资源，以生成初步数据 出版物和后续赠款申请；(2)增加AI/AN、NHPI和其他URM的数量 进行ADRD研究的调查人员；(3)启动和维护高级管理人员之间的指导关系 (4)提高NAD-RCMAR科学家的方法学技能 透过有关研究方法及其先导研究的教育课程；及(五) 确保试验结果发表在影响力较大的参考期刊上，并获得外部资金。NAD- RCMAR将要求在ADRD研究中代表AI/ANS和NHPI，同时参与早期和中期阶段的研究 职业培训和研究活动中的专业人员，为他们的独立做准备 调查人员，从而丰富和推进这一调查领域，并使劳动力多样化。

ABSTRACT – Research Education Component More than 6 million people in the US have Alzheimer’s disease or related dementias (ADRD). The extant literature suggests that the risk of ADRD are higher among racial and ethnic minorities, especially American Indians and Alaska Natives (AI/AN) and Native Hawaiians or Pacific Islanders (NHPIs). Unfortunately, there is a paucity of critical research on ADRD in Indigenous peoples. A search of the PubMed database using MeSH terms “Alzheimer’s disease” and “American Indian or Alaska Native” retrieved just 32 relevant publications, while a parallel search for NHPIs returned only 19 publications. AI/ANs and NHPIs are also underrepresented in the NIA-funded Alzheimer’s Disease Research Centers Program with only 454 of 45,923 participants in the 37 Centers over the past 17 years primarily identifying as AI/AN or NHPI. Because the data from these Centers lead to some of the most influential ADRD studies, poor representation of AI/AN and NHPI participants assures that they make limited contributions to research findings, healthcare policy or clinical treatment standards. Furthermore, because very few AI/AN or NHPI scientists conduct ADRD research. The goal of the Native Alzheimer’s Disease Resource Center in Minority Aging Research (NAD-RCMAR) is to build research capacity, enhance diversity in the professional workforce, and nurture innovative social, behavioral, epidemiological, and clinical research in ADRD. The scientific focus of the Research Education Component (REC) will be health disparities related to ADRD in AI/ANs and NHPIs by focusing on modifiable risk and resilience factors occurring in mid- and late-life that both increase the risk of ADRD and are highly relevant to AI/AN and NHPI communities. The REC will enhance the diversity of the ADRD research workforce by mentoring promising NAD-RCMAR Scientists especially from underrepresented minority (URM) groups, focusing on AI/ANs and NHPIs. The REC will offer NAD-RCMAR Scientists support in study design and measurement for our Pilot Studies and will deliver a workshop modelled after the highly successful Grantwriting Uncovered: Maximizing Strategies, Help, Opportunities, Experiences (GUMSHOE) program. Our Specific Aims are to: (1) Offer logistical, and scientific resources to support innovative Pilot Studies on ADRD in AI/ANs and NHPIs to generate preliminary data for publications and subsequent grant applications; (2) Increase the number of AI/AN, NHPI, and other URM investigators conducting ADRD research; (3) Initiate and maintain mentoring relationships between senior researchers and NAD-RCMAR Scientists; (4) Improve the methodological skills of NAD-RCMAR Scientists through didactic educational sessions on research methods and their conduct of Pilot Study research; and (5) Ensure Pilot findings are published in high-impact refereed journals and lead to extramural funding. The NAD- RCMAR will require representation of AI/ANs and NHPIs in ADRD studies, while engaging early- and mid-stage professionals in career training and research activities that will prepare them to become independent investigators, thereby enriching and advancing this field of inquiry and diversifying the workforce.