Res-Ed-Component

研究教育核心摘要 美国有500多万人患有阿尔茨海默病或相关痴呆症(ADRD)。最近的数据显示 可归因于ADRD的死亡率正在飙升，特别是在美洲印第安人和阿拉斯加土著中 (AI/AN)，其中ADRD死亡率在1999至2014年间上升了80%。没有针对具体人口的估计 可用于夏威夷土著或太平洋岛民(NHPI)，但ADRD死亡率在#年一般人口中 夏威夷同期增长59%。然而，人工智能/人工智能和NHPI参与者很少包括在ADRD中 研究，尽管预期寿命显著增加。此外，因为很少有人工智能/人工智能或NHPI科学家 进行ADRD研究，这一研究领域不会从独特的“局内人”视角中受益，即 研究人员会提供。这个少数民族老龄化方面的本土阿尔茨海默病相关资源中心的目标 研究(NAD-RCMAR)是为了建设研究能力，增强专业劳动力的多样性，以及 培育有关ADRD的创新社会科学、行为和经济研究。世界银行的科学焦点 研究教育部分将是AI/ANS和NHPI中与ADRD相关的人口层面的健康差距， 包括行为、社会文化和环境因素，以健康差距研究为基础 NIA认可的框架。每个参与先导研究的NAD-RCMAR科学家都将有一个指导团队 由一名生物统计学家、一名成功的代表不足少数群体(URM)研究人员和一名高级科学家组成。 另一个关键组成部分将是关于ADRD、研究方法、健康差距和少数族裔老龄化的培训。 这些综合活动将帮助NAD-RCMAR科学家获得外部资金，如K和 R01系列。我们将与科罗拉多大学和斯坦福大学的研究人员合作，利用 我们通过我们目前资助的RCMAR，原住民，在过去20年中取得的成功和吸取的教训 老年人研究中心。我们还将受益于我们与3阿尔茨海默氏症领导层的持续合作 疾病中心，并积极向AI/AN、NHPI和其他URM调查人员征集试点申请。我们的 具体目标是：1)提供财政、后勤和科学资源，支持关于ADRD的试点研究 在AI/AN或NHPI社区之间，以便生成用于后续赠款的初步人口数据 应用；2)增加有能力进行ADRD研究的AI/AN和NHPI专业人员的数量； 3)启动和维护高级研究人员和NAD-RCMAR科学家之间的指导关系；4) 通过参与试点研究和提高NAD-RCMAR科学家的方法技能 教育会议；以及5)在影响力较大的期刊上发表试点研究的结果。NIA领导层表示 人工智能/人工神经网络和其他URM是ADRD研究中优先考虑的人群。NAD-RCMAR将促进 他们参与试点研究，同时让NAD-RCMAR的科学家参加职业培训和研究 这些活动将使他们做好成为独立调查人员的准备，并丰富这一调查领域。

RESEARCH EDUCATION CORE ABSTRACT More than 5 million people in the US have Alzheimer’s disease or related dementias (ADRD). Recent data show that rates of mortality attributable to ADRD are soaring, especially among American Indians and Alaska Natives (AI/AN), among whom ADRD mortality rose by 80% between 1999 and 2014. No population-specific estimates are available for Native Hawaiians or Pacific Islanders (NHPIs), but ADRD mortality in the general population of Hawaii increased by 59% over the same period. Yet, AI/AN and NHPI participants are rarely included in ADRD research, despite striking increases in life expectancy. Furthermore, because very few AI/AN or NHPI scientists conduct ADRD research, this field of study receives no benefit from the unique “insider” perspectives that such researchers would offer. The goal of this Native Alzheimer’s Disease-related Resource Center in Minority Aging Research (NAD-RCMAR) is to build research capacity, enhance diversity in the professional workforce, and nurture innovative social science, behavioral, and economic research on ADRD. The scientific focus of the Research Education Component will be population-level health disparities related to ADRD in AI/ANs and NHPIs, including behavioral, sociocultural, and environmental factors, grounded in the health disparities research framework endorsed by NIA. Each NAD-RCMAR Scientist engaged in a Pilot Study will have a mentoring team comprising a biostatistician, a successful underrepresented minority (URM) researcher, and a senior scientist. Another key component will be training on ADRD, research methods, health disparities, and minority aging. These integrated activities will help NAD-RCMAR Scientists obtain external funding, such as grants in the K and R01 series. We will partner with researchers at the University of Colorado and Stanford University and leverage our successes and lessons learned over the past 20 years through our currently funded RCMAR, the Native Elder Research Center. We will also benefit from our ongoing collaborations with the leadership of 3 Alzheimer’s Disease Centers and actively solicit pilot applications from AI/AN, NHPI, and other URM investigators. Our Specific Aims are to: 1) Offer financial, logistical, and scientific resources to support Pilot Studies on ADRD among AI/AN or NHPI communities in order to generate preliminary population-level data for subsequent grant applications; 2) Increase the number of AI/AN and NHPI professionals capable of conducting ADRD research; 3) Initiate and maintain mentoring relationships between senior researchers and NAD-RCMAR Scientists; 4) Improve the methodological skills of NAD-RCMAR Scientists through their participation in Pilot Studies and educational sessions; and 5) Publish findings of Pilot Studies in high-impact journals. NIA leadership has stated that AI/ANs and other URMs are priority populations to include in ADRD research. NAD-RCMAR will promote their participation in Pilot Studies while engaging NAD-RCMAR Scientists in career training and research activities that will prepare them to become independent investigators and enrich this field of inquiry.