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Flow Cytometry Core

流式细胞术核心

基本信息

批准号：
10208900
负责人：
Timothy E O'Toole
金额：
$ 16.22万
依托单位：
UNIVERSITY OF LOUISVILLE
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10208900
关键词：
Address Adipocytes Adopted Antigens Apoptotic Area Award Biological Assay Blood Cell Count Blood Platelets Cardiovascular system Cell Therapy Cells Centers of Research Excellence Chemicals Clinical Research Color Communities Continuing Education Coupled Data Data Analyses Detection Diabetes Mellitus Dyes Epidemic Equipment Event Extramural Activities Fee-for-Service Plans Fees Felis catus Flow Cytometry Foundations Funding Future Generations Goals Grant Health Hazards Human Resources Immune Individual Institutes Institution Metabolism Monitor Nature Obesity Phase Population Analysis Procedures Protocols documentation Reagent Research Research Activity Research Personnel Research Project Grants Resources Sampling Services Signal Transduction Structure Techniques Tissues Training Universities Work analytical tool antigen detection base career development cell determination clinical investigation diabetic patient event cycle experience experimental study innovation instrument interest investigator training macrophage meetings member mitochondrial membrane monocyte novel obese patients operation peripheral blood programs rapid detection stem cell population synergism theories tissue stem cells

项目摘要

ABSTRACT The Flow Cytometry Core (Core B) has four major goals. Its primary function is to provide state of the art equipment and expertise for flow cytometric analysis of cellular antigen expression, function, metabolism and signaling thereby supporting cardiovascular research in diabetes and obesity at the University of Louisville. Core B personnel are highly-experienced investigators who have worked for several years on flow cytometry using various tissues and cells from multiple species and have extensive expertise in rare event analysis. The complementary nature of their backgrounds and areas of expertise, coupled with their collegial nature, provides a strong foundation for productive synergy within this Core and its productive interactions with other investigators in the DOC, at the UofL and with collaborative interactions with other Institutes. Secondly, the Core is committed to an educational goal. Not only will all users be trained on the operation of instruments, it is the intent that these users completely understand cytometric theory, application, and data analysis. Through hands-on training and educational presentations, it is hoped that all current and future users will be able to competently incorporate flow cytometry as an analytical tool. Third, the Core is committed to developing its scope and operation to support multidimensional flow cytometry needs in the future. It will continue to upgrade its equipment and analytical repertoire. Finally, this Core has the ultimate goal of developing into a self-supporting and large-scale flow cytometry operation that will cater not only to the specific needs of the Center but to other University and extramural investigators interested in diabetes and obesity research. A fully developed Flow Cytometry Core will be a significant asset in developing future multi-investigator projects and for helping researchers conduct multifaceted basic and clinical investigations aimed at the amelioration of health hazards caused by diabetes and obesity.

摘要