ConProject-004

美国心脏协会 (AHA) 烟草监管中心 (ATRAC) 的总体目标是提供 与美国食品药品监督管理局 (FDA) 烟草中心监管机构相关的科学数据 产品（CTP）。该中心的综合主题是评估和交流心血管影响 烟草制品的健康影响、毒性和传播科学领域。研究 该中心将通过评估烟草监管科学的科学基础来做出贡献 烟草制品及其成分对心血管的影响。该中心将支持多学科 评估烟草制品及其成分在体外试验和动物中的毒性的研究计划 模型（项目1）；评估烟草制品对心血管健康的短期和长期影响（项目 2） 并评估与在多种情况下使用非卷烟烟草制品相关的心血管疾病风险 NIH 支持的大型心血管队列（项目 3）。传达内部产生的知识 中心和其他烟草监管科学中心 (TCORS)，该中心将开发和测试方法 有效沟通烟草制品使用对心血管的影响（项目 4）。为了方便 一致性和质量控制，所有测量都将在集中的生物分析和生物标记中进行 核心。中心内的研究活动将由行政核心协调，而职业 增强核心将监督新的和早期研究人员的职业发展。的 行政核心将与联邦合作伙伴保持密切沟通，并监督发展， 快速反应项目的资金和进展。该中心支持的研究将开发新的 了解当前、新型和新兴烟草产品对心血管的影响；援助 制定传达与吸烟相关的心血管风险的信息 产品；建立和部署能力和专业知识以应对新的发展。集体地，中心 研究将扩大烟草监管科学的科学基础，为 FDA 的烟草监管提供信息 制造、分销和营销。

The overall goal of the American Heart Association (AHA) Tobacco Regulation Center (ATRAC) is to provide scientific data relevant to the regulatory authority of the Food and Drug Administration (FDA) Center for Tobacco Products (CTP). The integrative theme of the Center is to evaluate and communicate the cardiovascular effects of tobacco products, within the scientific domains of Health Effects, Toxicity and Communications. Research within the Center will contribute to the scientific base of tobacco regulatory science by evaluating the cardiovascular effects of tobacco products and their constituents. The Center will support a multi-disciplinary research program to assess the toxicity of tobacco products and their constituents in in vitro assays and animal models (Project 1); evaluate short- and long-term cardiovascular health effects of tobacco products (Project 2) and assess the cardiovascular disease risk associated with the use of non-cigarette tobacco products in multiple large NIH-supported cardiovascular cohorts (Project 3). To communicate the knowledge generated within the Center and other Tobacco Centers of Regulatory Science (TCORS), the Center will develop and test approaches for effective communication of the cardiovascular consequences of tobacco product use (Project 4). To facilitate uniformity, and quality control, all measurements will be conducted in a centralized Bioanalytical and Biomarker Core. The research activities within the Center will be coordinated by an Administrative Core, while the Career Enhancement Core will oversee the career development of new and early stage investigators. The Administrative Core will maintain close communication with federal partners and will oversee the development, funding and progress of Rapid Response Projects. Research supported by the Center will develop new understanding of the cardiovascular effects of current, new and emerging tobacco products; aid in the development of messages for communicating the cardiovascular risk associated with the use of tobacco products; and build and deploy capacity and expertise to respond to new developments. Collectively, Center research will broaden the scientific base of tobacco regulatory science to inform FDA's regulation of tobacco manufacturing, distribution and marketing.