Training in Musculoskeletal Science: Comprehensive Training in Pain Studies

摘要：本行政补充方案旨在加强罗切斯特的肌肉骨骼训练 科学(ROCMSK)计划，纳入关于机制的综合培训课程， 疼痛的测量和治疗。拟议的课程将补充现有的跨学科 肌肉骨骼科学的教学、教学和研究技能培训，同时填补疼痛的关键空白 骨科条件下的评估和管理。培训课程将对所有人开放 CMSR项目内各个学术级别的学员，经验型T32学员优先 学习机会。课程包括基于讲座的教学和身临其境的动手培训， 涵盖从疼痛生理学和临床前疼痛模型到疼痛评估方法和 道德考量。疼痛评估的严谨性、可重复性和标准化的重要性 将强调方法。学员将有机会与著名的疼痛研究人员接触 通过CMSR在芝加哥肌肉骨骼疼痛中心(C-COMP)的成员资格并接受 关于啮齿动物疼痛评估技术的培训。资金将用于购买疼痛行为 评估工具，加强CMSR中疼痛研究的基础设施。与C- COMP将实现未来专家的资源共享和培训，确保疼痛课程的可持续性 在ROCMSK T32程序中。该提案还旨在利用国家资源并创造 通过合作和参与疼痛研究为学员提供体验式学习机会 计划和活动。学员将受益于通过NIH的与疼痛研究专家的虚拟互动 治愈和有目的的主动行动。该补助金将支持学员参加面对面的工作坊， 研讨会和会议，包括关于哺乳动物躯体感觉和 国际疼痛研究协会会议。这种方法将促进跨学科合作。 并为学员提供关于前沿疼痛研究的不同视角。此外，该提案 要求增加一名受训人员的培训席位，以便将疼痛结果纳入他的研究 胰腺癌临床前模型中与骨骼肌萎缩相关的分子机制。这 研究有可能有助于开发预防或逆转的新疗法 胰腺癌患者的骨骼肌萎缩。总体而言，这项行政补充提案旨在 通过开发全面的疼痛评估培训课程来加强ROCMSK计划 以及肌肉骨骼状况的管理。通过授课、身临其境的实践训练， 体验式学习机会，以及增加一名专注于胰腺疼痛评估的实习生 癌症模型，这一补充旨在弥合在跨学科肌肉骨骼科学培训和 使未来的研究人员能够解决整形外科条件下疼痛的复杂问题。

Abstract: This administrative supplement proposal aims to enhance the Rochester Training in Musculoskeletal Science (ROCMSK) Program by incorporating a comprehensive training curriculum on the mechanisms, measurement, and treatment of pain. The proposed curriculum will complement the existing interdisciplinary didactic, pedagogical, and research skills training in musculoskeletal science while filling a critical gap in pain assessment and management in orthopedic conditions. The training curriculum will be accessible to all trainees at every academic level within the CMSR program, with priority given to T32 trainees for experiential learning opportunities. The curriculum includes lecture-based instruction and immersive hands-on training, covering topics ranging from pain physiology and preclinical pain models to pain assessment methods and ethical considerations. The importance of rigor, reproducibility, and standardization of pain assessment methods will be emphasized. Trainees will have the opportunity to engage with renowned pain researchers through the CMSR's membership in the Chicago Center on Musculoskeletal Pain (C-COMP) and receive training on pain assessment techniques in rodents. Funding will be used to purchase pain behavior assessment instruments, enhancing the infrastructure for pain studies in the CMSR. Collaboration with C- COMP will enable resource sharing and training of future experts, ensuring sustainability of the pain curriculum within the ROCMSK T32 program. The proposal also aims to leverage national resources and create experiential learning opportunities for trainees through collaborations and participation in pain research initiatives and events. Trainees will benefit from virtual interactions with pain research experts through NIH's HEAL and PURPOSE Initiatives. The supplement will support trainees in attending in-person workshops, symposia, and conferences, including the Keystone Symposia on Mammalian Somatosensation and the International Association for the Study of Pain meeting. This approach will foster interdisciplinary collaboration and provide trainees with diverse perspectives on cutting-edge pain research. Furthermore, the proposal requests an additional training seat for an additional trainee to incorporate pain outcomes into his study of molecular mechanisms related to skeletal muscle wasting in a preclinical model of pancreatic cancer. This research has the potential to contribute to the development of new therapies for preventing or reversing skeletal muscle wasting in pancreatic cancer patients. Overall, this administrative supplement proposal seeks to enhance the ROCMSK Program by developing a comprehensive training curriculum on pain assessment and management in musculoskeletal conditions. Through didactic instruction, immersive hands-on training, experiential learning opportunities, and the addition of a trainee focusing on pain assessment in a pancreatic cancer model, this supplement aims to bridge the gap in interdisciplinary musculoskeletal science training and empower future researchers to address the complex issue of pain in orthopedic conditions.