Clinical Translational Research Center for Neurodevelopmental Disorders

项目摘要 北卡罗来纳州大学智力和发育障碍研究中心（IDDRC）是一个 跨学科计划的总体目标是支持和促进相关研究， 了解神经发育障碍的发病机制和治疗。该委员会是一个关键的 新的卡罗莱纳发育障碍研究所（CIDD）的组成部分，这是一个协调中心， 与智力和发育障碍（IDDs）有关的临床服务，研究和培训， 在校园里。该中心目前支持来自13个大学部门的46名调查人员， 包括89个外部资助的研究项目。这个IDDRC的基础广泛的研究计划是 综合围绕3个主题：（1）大脑和行为发展;（2）自闭症和相关 神经发育障碍;（3）早期发现/干预。该委员会是一个高度 一个合作项目，突出了几个NIH资助的跨学科研究的存在 中心/方案。本申请寻求支持：（1）一个行政核心;（2）三个研究核心- 临床转化核心，包括研究参与者登记和大脑行为 测量实验室;临床前核心，其中包括小鼠行为表型实验室， 神经科学显微镜设施和小动物成像设施;数据科学核心核心;以及（3） 临床前/临床研究项目，题为“神经发育中的脑脊液异常 疾病”，建议检查CSF病理生理学在所选疾病发病机制中的作用。 神经发育障碍这三个拟议的研究核心提供尖端，高品质和成本 有效支持这一综合性、多学科、转化性的缺碘症相关研究方案。总的来说， 该中心对发展性残疾研究和科学培训产生了重大影响， 北卡罗来纳州大学，并更新将使我们能够继续我们的支持真正的特殊 在北京进行的碘缺乏病研究计划。

Project Summary The University of North Carolina Intellectual and Developmental Disabilities Research Center (IDDRC) is an interdisciplinary program with the overarching goal of supporting and promoting research relevant to understanding the pathogenesis and treatment of neurodevelopmental disorders. The UNC IDDRC is a critical component of the new Carolina Institute for Developmental Disabilities (CIDD), which is the focal point for clinical services, research, and training relevant to intellectual and developmental disabilities (IDDs) on the UNC campus. The UNC IDDRC currently supports 46 investigators from 13 University departments, and includes 89 externally-funded research projects. The broad-based research program of this IDDRC is integrated around 3 themes: (1) Brain and Behavior Development; (2) Autism and Related Neurodevelopmental Disorders; and, (3) Early Detection/Intervention. The UNC IDDRC is a highly collaborative program highlighted by the presence of several NIH-funded, interdisciplinary research centers/programs. This application seeks support for: (1) an Administrative Core; (2) three research cores – the Clinical Translational Core, which includes the Research Participant Registry and Brain-Behavior Measurement Laboratory; the PreClinical Core, which includes the Mouse Behavioral Phenotyping Laboratory, Neuroscience Microscopy Facility, and Small Animal Imaging Facility; the Data Science Core Core; and (3) a pre-clinical/clinical research project entitled “Cerebrospinal fluid abnormalities in neurodevelopmental disorders” that proposes to examine role of CSF pathophysiology in the pathogenesis of selected neurodevelopmental disorders. The three proposed research cores provide cutting-edge, high-quality and cost effective support for this integrated, multidisciplinary, translational program of IDD-relevant research. Overall, this Center has had a major impact on developmental disabilities research and scientific training at the University of North Carolina, and renewal would allow us to continue our support of the truly exceptional program of IDD research conducted at UNC.