Clinical Translational Research Center for Neurodevelopmental Disorders

项目摘要 北卡罗来纳大学智力与发展障碍研究中心(IDDRC) 跨学科计划，主要目标是支持和促进与以下领域相关的研究 了解神经发育障碍的发病机制和治疗。北卡罗来纳大学国际数据发展中心是一个关键 新的卡罗莱纳发育障碍研究所(CIDD)的组成部分，它是 与智力和发育障碍(IDDS)相关的临床服务、研究和培训 北卡罗来纳大学校园。北卡罗来纳大学国际发展研究中心目前支持来自13个大学系的46名调查人员，以及 包括89个外部资助的研究项目。IDDRC的基础广泛的研究计划是 围绕三个主题整合：(1)大脑和行为发展；(2)自闭症及其相关 神经发育障碍；以及(3)早期发现/干预。北卡罗来纳大学国际数据中心是一个高度 几项由美国国立卫生研究院资助的跨学科研究突出了合作计划 中心/项目。本申请寻求支持：(1)行政核心；(2)三个研究核心- 临床翻译核心，包括研究参与者注册和大脑行为 测量实验室；临床前核心，包括小鼠行为表型实验室， 神经科学显微镜设备和小动物成像设备；数据科学核心；以及(3) 《神经发育中的脑脊液异常》临床前/临床研究项目 疾病“，建议研究脑脊液病理生理学在所选疾病发病中的作用 神经发育障碍。拟议的三个研究核心提供尖端、高质量和低成本 有效地支持这一综合的、多学科的、与IDD相关的研究的翻译计划。总的来说， 该中心在发展性残疾研究和科学培训方面产生了重大影响 北卡罗来纳大学，续签将使我们能够继续支持真正特殊的 北卡罗来纳大学开展的IDD研究计划。

Project Summary The University of North Carolina Intellectual and Developmental Disabilities Research Center (IDDRC) is an interdisciplinary program with the overarching goal of supporting and promoting research relevant to understanding the pathogenesis and treatment of neurodevelopmental disorders. The UNC IDDRC is a critical component of the new Carolina Institute for Developmental Disabilities (CIDD), which is the focal point for clinical services, research, and training relevant to intellectual and developmental disabilities (IDDs) on the UNC campus. The UNC IDDRC currently supports 46 investigators from 13 University departments, and includes 89 externally-funded research projects. The broad-based research program of this IDDRC is integrated around 3 themes: (1) Brain and Behavior Development; (2) Autism and Related Neurodevelopmental Disorders; and, (3) Early Detection/Intervention. The UNC IDDRC is a highly collaborative program highlighted by the presence of several NIH-funded, interdisciplinary research centers/programs. This application seeks support for: (1) an Administrative Core; (2) three research cores – the Clinical Translational Core, which includes the Research Participant Registry and Brain-Behavior Measurement Laboratory; the PreClinical Core, which includes the Mouse Behavioral Phenotyping Laboratory, Neuroscience Microscopy Facility, and Small Animal Imaging Facility; the Data Science Core Core; and (3) a pre-clinical/clinical research project entitled “Cerebrospinal fluid abnormalities in neurodevelopmental disorders” that proposes to examine role of CSF pathophysiology in the pathogenesis of selected neurodevelopmental disorders. The three proposed research cores provide cutting-edge, high-quality and cost effective support for this integrated, multidisciplinary, translational program of IDD-relevant research. Overall, this Center has had a major impact on developmental disabilities research and scientific training at the University of North Carolina, and renewal would allow us to continue our support of the truly exceptional program of IDD research conducted at UNC.