Clinical Translational Research Center for Neurodevelopmental Disorders

神经发育障碍临床转化研究中心

• 批准号: 9110033
• 负责人: Joseph Piven
• 金额: $ 130万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-24 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9110033
• 关键词: Address; Animal Experimentation; Autistic Disorder; Basic Science; Behavioral; Bioinformatics; Biostatistics Core; Brain; Brain imaging; Caliber; Center for Translational Science Activities; Child; Clinical; Clinical Research; Clinical Sciences; Clinical Services; Collaborations; Complex; Development; Developmental Disabilities; Discipline; Early Diagnosis; Early Intervention; Elements; Environment; Fostering; Functional Magnetic Resonance Imaging; Funding; Goals; Health Services Research; Human; Image Analysis; Individual; Institutes; Intellectual functioning disability; Interdisciplinary Study; Intervention; Laboratories; Measurement; Mediating; Mental Retardation and Developmental Disabilities Research Centers; Mentorship; Microscopy; Motivation; Mus; National Institute of Child Health and Human Development; Nature; Neurodevelopmental Disorder; Neurons; North Carolina; Oxytocin; Participant; Pathogenesis; Pathway interactions; Personal Satisfaction; Phenotype; Pre-Clinical Model; Prevention; Prevention strategy; Registries; Regulation; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Rewards; Sampling; Science; Social Behavior; Syndrome; Training; Training and Education; Translational Research; U-Series Cooperative Agreements; United States National Institutes of Health; Universities; autism spectrum disorder; base; brain behavior; collaborative environment; cost effective; disability; improved; innovation; interest; mesolimbic system; motivated behavior; mouse model; multidisciplinary; neural circuit; new therapeutic target; optogenetics; pre-clinical; pre-doctoral; programs; response; reward circuitry; social; training opportunity

DESCRIPTION (provided by applicant): The University of North Carolina Intellectual and Developmental Disabilities Research Center (IDDRC) is an interdisciplinary program with the overarching goal of supporting and promoting research relevant to understanding the pathogenesis and treatment of neurodevelopmental disorders. The UNC IDDRC is a critical component of the new Carolina Institute for Developmental Disabilities (CIDD), which is the focal point for clinical services, research, and training relevant to intellectual and developmenta disabilities (IDDs) on the UNC campus. The UNC IDDRC currently supports 39 investigators from 16 University departments, and includes 67 externally-funded research projects. The broad-based research program of this IDDRC is integrated around 3 themes: (1) Autism and Related Neurodevelopmental Disorders; (2) Brain and Behavior Development; and, (3) Early Detection/Intervention. The UNC IDDRC is a highly collaborative program highlighted by the presence of several NIH-funded, interdisciplinary research centers/programs. This application seeks support for: (1) an Administrative Core; (2) three research cores - a Clinical Translational Core, which includes the Research Participant Registry and Brain Measurement Laboratory; a Preclinical Core, which includes the Mouse Behavioral Phenotyping, Brain Imaging Analysis, and Confocal/Multiphoton Microscopy Labs; and the Bioinformatics/Biostatistics Core; and (3) a preclinical/clinical research project entitled "Neural Circuit Regulation of Social Reward Motivation" potentially providing important new information related to novel therapeutic targets for normalizing social behavior in individuals with ASD. The three proposed research cores provide cutting-edge, high-quality and cost effective support for this integrated, multidisciplinar, translational program of IDD-relevant research. Overall, this Center has had a major impact on developmental disabilities research and scientific training at the University of North Carolina, and renewal would allow us to continue our support of the truly exceptional program of IDD research conducted at UNC.

描述(由申请人提供)：北卡罗来纳大学智力和发育障碍研究中心(IDDRC)是一个跨学科项目，主要目标是支持和促进与了解神经发育障碍的发病机制和治疗相关的研究。北卡罗来纳大学IDDRC是新成立的卡罗莱纳发育障碍研究所(CIDD)的重要组成部分，该研究所是北卡罗来纳大学校园内与智力和发育障碍(IDDS)相关的临床服务、研究和培训的中心。北卡罗来纳大学国际发展研究中心目前支持来自16个大学系的39名研究人员，包括67个外部资助的研究项目。IDDRC的基础广泛的研究计划围绕三个主题进行整合：(1)自闭症和相关的神经发育障碍；(2)大脑和行为发展；以及(3)早期发现/干预。北卡罗来纳州大学国际数据发展研究中心是一个高度协作的项目，由NIH资助的几个跨学科研究中心/项目的存在凸显了这一点。这项申请寻求支持：(1)行政核心；(2)三个研究核心--临床翻译核心，包括研究参与者登记处和脑测量实验室；临床前核心，包括小鼠行为表型分析、脑成像分析、共焦/多光子显微镜实验室；以及生物信息学/生物统计学核心；以及(3)临床前/临床研究项目，题为“社会奖励动机的神经回路调节”，可能提供与ASD患者社会行为正常化的新治疗目标相关的重要新信息。这三个拟议的研究核心为这一综合的、多学科的、翻译的IDD相关研究项目提供了尖端、高质量和成本效益高的支持。总体而言，该中心对北卡罗来纳大学的发育障碍研究和科学培训产生了重大影响，续签该中心将使我们能够继续支持北卡罗来纳大学开展的真正特殊的IDD研究项目。