Clinical Translational Research Center for Neurodevelopmental Disorders

神经发育障碍临床转化研究中心

• 批准号: 9110033
• 负责人: Joseph Piven
• 金额: $ 130万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-24 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9110033
• 关键词: Address; Animal Experimentation; Autistic Disorder; Basic Science; Behavioral; Bioinformatics; Biostatistics Core; Brain; Brain imaging; Caliber; Center for Translational Science Activities; Child; Clinical; Clinical Research; Clinical Sciences; Clinical Services; Collaborations; Complex; Development; Developmental Disabilities; Discipline; Early Diagnosis; Early Intervention; Elements; Environment; Fostering; Functional Magnetic Resonance Imaging; Funding; Goals; Health Services Research; Human; Image Analysis; Individual; Institutes; Intellectual functioning disability; Interdisciplinary Study; Intervention; Laboratories; Measurement; Mediating; Mental Retardation and Developmental Disabilities Research Centers; Mentorship; Microscopy; Motivation; Mus; National Institute of Child Health and Human Development; Nature; Neurodevelopmental Disorder; Neurons; North Carolina; Oxytocin; Participant; Pathogenesis; Pathway interactions; Personal Satisfaction; Phenotype; Pre-Clinical Model; Prevention; Prevention strategy; Registries; Regulation; Research; Research Personnel; Research Project Grants; Research Support; Research Training; Resources; Rewards; Sampling; Science; Social Behavior; Syndrome; Training; Training and Education; Translational Research; U-Series Cooperative Agreements; United States National Institutes of Health; Universities; autism spectrum disorder; base; brain behavior; collaborative environment; cost effective; disability; improved; innovation; interest; mesolimbic system; motivated behavior; mouse model; multidisciplinary; neural circuit; new therapeutic target; optogenetics; pre-clinical; pre-doctoral; programs; response; reward circuitry; social; training opportunity

DESCRIPTION (provided by applicant): The University of North Carolina Intellectual and Developmental Disabilities Research Center (IDDRC) is an interdisciplinary program with the overarching goal of supporting and promoting research relevant to understanding the pathogenesis and treatment of neurodevelopmental disorders. The UNC IDDRC is a critical component of the new Carolina Institute for Developmental Disabilities (CIDD), which is the focal point for clinical services, research, and training relevant to intellectual and developmenta disabilities (IDDs) on the UNC campus. The UNC IDDRC currently supports 39 investigators from 16 University departments, and includes 67 externally-funded research projects. The broad-based research program of this IDDRC is integrated around 3 themes: (1) Autism and Related Neurodevelopmental Disorders; (2) Brain and Behavior Development; and, (3) Early Detection/Intervention. The UNC IDDRC is a highly collaborative program highlighted by the presence of several NIH-funded, interdisciplinary research centers/programs. This application seeks support for: (1) an Administrative Core; (2) three research cores - a Clinical Translational Core, which includes the Research Participant Registry and Brain Measurement Laboratory; a Preclinical Core, which includes the Mouse Behavioral Phenotyping, Brain Imaging Analysis, and Confocal/Multiphoton Microscopy Labs; and the Bioinformatics/Biostatistics Core; and (3) a preclinical/clinical research project entitled "Neural Circuit Regulation of Social Reward Motivation" potentially providing important new information related to novel therapeutic targets for normalizing social behavior in individuals with ASD. The three proposed research cores provide cutting-edge, high-quality and cost effective support for this integrated, multidisciplinar, translational program of IDD-relevant research. Overall, this Center has had a major impact on developmental disabilities research and scientific training at the University of North Carolina, and renewal would allow us to continue our support of the truly exceptional program of IDD research conducted at UNC.

描述（由申请人提供）：北卡罗来纳州大学智力和发育障碍研究中心（IDDRC）是一个跨学科的计划，其总体目标是支持和促进与了解神经发育障碍的发病机制和治疗相关的研究。该中心是新的卡罗莱纳研究所发育障碍（CIDD），这是临床服务，研究和培训有关的智力和发育障碍（IDDs）在校园的焦点的重要组成部分。该中心目前支持来自16个大学部门的39名研究人员，并包括67个外部资助的研究项目。该IDDRC的基础广泛的研究计划围绕3个主题进行整合：（1）自闭症和相关神经发育障碍;（2）大脑和行为发育;（3）早期检测/干预。该candiddrc是一个高度合作的程序突出了几个NIH资助的，跨学科的研究中心/方案的存在。该申请寻求对以下方面的支持：（1）管理核心;（2）三个研究核心-临床转化核心，包括研究参与者登记和脑测量实验室;临床前核心，包括小鼠行为表型分析、脑成像分析和共聚焦/多光子显微镜实验室;以及生物信息学/生物统计学核心;以及（3）名为“社会奖励动机的神经回路调节”的临床前/临床研究项目，其潜在地提供与用于使患有ASD的个体的社会行为正常化的新型治疗靶点相关的重要新信息。这三个拟议的研究核心为这个综合的、多学科的、转化的IDD相关研究项目提供了尖端、高质量和成本效益的支持。总的来说，该中心对北卡罗来纳州大学的发育障碍研究和科学培训产生了重大影响，更新将使我们能够继续支持在北卡罗来纳州进行的真正特殊的IDD研究计划。