MRI Based Presymptomatic Prediction of ASD
基于 MRI 的 ASD 症状前预测
基本信息
- 批准号:9981943
- 负责人:
- 金额:$ 84.79万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-04-01 至 2024-01-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAgeAge-MonthsAmygdaloid structureAnisotropyAnteriorAreaAxonBehaviorBehavioralBiological MarkersBrainBrain imagingBudgetsCell modelCerebrospinal FluidCharacteristicsClinicalCorpus CallosumDataDevelopmentDiagnosisDiagnosticDiffuseDiffusionDiffusion Magnetic Resonance ImagingDiseaseDown SyndromeFiberFunctional ImagingFundingGeneral PopulationGoalsGrowthImpairmentInfantInfant DevelopmentLanguageLifeLongitudinal StudiesMRI ScansMagnetic Resonance ImagingMapsMeasuresMotorNational Institute of Mental HealthOutcomeOutcome AssessmentParticipantPatternPredictive ValueProcessPropertyProspective cohortProtocols documentationPublishingRadialReportingResearchResearch PersonnelResourcesRiskSamplingScanningScheduleSiblingsStructureSubgroupSurfaceSymptomsTestingTimeWorkautism spectrum disorderbasebehavior changebehavioral studybrain behaviorbrain tissuebrain volumecerebrospinal fluid flowclinical research siteclinically actionablecohortdensitydrug developmenthigh riskimaging studyindexinginfancyinsightjoint attentionmultimodalitynerve stem celloutcome predictionparent projectpredictive testprospectiverate of changerepetitive behaviorsocial deficitstherapeutic targettime intervalwhite matter
项目摘要
ABSTRACT
This is an application for a 4 year competitive supplement to add a multimodal MRI scan, at 24 months of age,
to a newly funded study that aims to replicate and extend our findings predicting autism spectrum disorder
(ASD) in high familial risk (HR) infants using MRI scans in the first year of life. HR infants (who have an older
affected sibling) have approximately a 12-fold increase in their risk (1/5 vs 1/59) to develop ASD. In HR infants
who develop ASD, the first year of life is a period that is relatively free of the defining behavioral characteristics
of the disorder, which then consolidate into full diagnosis over the second year of life and beyond. Longitudinal
studies involving structural, diffusion, and functional imaging from the Infant Brain Imaging Study (IBIS)
Network (https://www.ibis-network.org/) have produced new and fundamental insights into early brain and
behavior changes across 6-24 months of age in infants who later meet criteria for ASD. The IBIS Network
received funding in April 2019 to replicate and extend findings showing that structural and functional
connectivity (fcMRI) MRI scans at 6 and 12 months of age can accurately (positive predictive values greater
than 80%) predict ASD diagnosis at 24 months of age. This new study (IBIS-Early Prediction or “IBIS-EP”)
seeks to advance the field toward a clinically actionable, predictive test for ASD in HR infants. The NIMH-
approved budget for IBIS-EP, however, does not include support for a 24 month scan of HR infants. Without a
24 month scan, it will not be possible to replicate or extend IBIS’ critical findings about brain development [1-8],
that are temporally specific and require the 24-month scan for characterization of the precise timing of brain
changes. This competitive supplement would allow us to acquire, process, and analyze 24 month multimodal
MRI scans for the 250 HR infants participating in the IBIS-EP study (who are already scheduled to return for 24
month diagnostic assessment). This time sensitive opportunity to leverage resources from IBIS-EP, and data
from two parallel studies by IBIS co-investigators involving 80 low-risk (LR) infants, would allow us (Aim 1) to
attempt to replicate our previous reports of age-specific, structural, diffusion, and functional connectivity MRI
brain changes at 6-12 and 24 months; and (Aim 2) to investigate potential mechanisms underlying previously
reported MRI findings in a new, prospective cohort, scanned through 24 months. Studies will examine the
development of increased cerebrospinal fluid and aberrant white matter microstructure in ASD vs. HR-negative
and LR groups, and test ASD outcome group-based differences in brain functional connectivity. The addition of
a 24 month scan would, therefore, dramatically increase the impact of the parent project by: 1) identifying
specific developmental windows (i.e., time intervals with significant group differences in change rate of brain
features that correspond to later clinical outcomes); 2) identifying biomarkers of homogenous subgroups and
symptom progression; and 3) identifying therapeutic targets, e.g., brain volume expansion as a marker of over-
proliferation of neural progenitor cells, for study in cross-species and cellular models to aid drug development.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Joseph Piven其他文献
Joseph Piven的其他文献
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{{ truncateString('Joseph Piven', 18)}}的其他基金
Clinical Translational Research Center for Neurodevelopmental Disorders
神经发育障碍临床转化研究中心
- 批准号:
10224307 - 财政年份:2020
- 资助金额:
$ 84.79万 - 项目类别:
Clinical Translational Research Center for Neurodevelopmental Disorders
神经发育障碍临床转化研究中心
- 批准号:
10085965 - 财政年份:2020
- 资助金额:
$ 84.79万 - 项目类别:
MRI Based Presymptomatic Prediction of ASD
基于 MRI 的 ASD 症状前预测
- 批准号:
9899322 - 财政年份:2019
- 资助金额:
$ 84.79万 - 项目类别:
Clinical Translational Research Center for Neurodevelopmental Disorders
神经发育障碍临床转化研究中心
- 批准号:
8740533 - 财政年份:2013
- 资助金额:
$ 84.79万 - 项目类别:
Clinical Translational Research Center for Neurodevelopmental Disorders
神经发育障碍临床转化研究中心
- 批准号:
9923806 - 财政年份:2013
- 资助金额:
$ 84.79万 - 项目类别:
Clinical Translational Research Center for Neurodevelopmental Disorders
神经发育障碍临床转化研究中心
- 批准号:
9296167 - 财政年份:2013
- 资助金额:
$ 84.79万 - 项目类别:
Clinical Translational Research Center for Neurodevelopmental Disorders
神经发育障碍临床转化研究中心
- 批准号:
9110033 - 财政年份:2013
- 资助金额:
$ 84.79万 - 项目类别:
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