Clinical Translational Research Center for Neurodevelopmental Disorders

描述（由申请人提供）：北卡罗来纳大学智力与发育障碍研究中心（IDDRC）是一个跨学科项目，其总体目标是支持和促进与了解神经发育障碍的发病机制和治疗相关的研究。北卡罗莱纳大学智力和发育障碍研究所是新卡罗莱纳大学发育障碍研究所的重要组成部分，该研究所是北卡罗莱纳大学校园智力和发育障碍（IDDs）相关临床服务、研究和培训的焦点。北卡罗来纳大学国际发展研究中心目前支持来自16个大学系的39名研究人员，包括67个外部资助的研究项目。该IDDRC的基础广泛的研究计划围绕三个主题进行整合：(1)自闭症和相关神经发育障碍；(2)大脑和行为发展；(3)早期发现/干预。UNC IDDRC是一个高度合作的项目，由几个美国国立卫生研究院资助的跨学科研究中心/项目组成。本申请寻求以下支持：(1)行政核心；(2)三个研究核心——临床转化核心，包括研究参与者注册中心和脑测量实验室；临床前核心，包括小鼠行为表型，脑成像分析和共聚焦/多光子显微镜实验室；以及生物信息学/生物统计学核心；(3)一项名为“社会奖励动机的神经回路调节”的临床前/临床研究项目，可能为ASD患者社会行为正常化的新治疗靶点提供重要的新信息。这三个拟议的研究核心为idd相关研究的综合、多学科、转化计划提供了前沿、高质量和成本效益的支持。总的来说，该中心对北卡罗来纳大学的发育性残疾研究和科学培训产生了重大影响，更新将使我们能够继续支持北卡罗来纳大学开展的真正杰出的发育性残疾研究项目。

DESCRIPTION (provided by applicant): The University of North Carolina Intellectual and Developmental Disabilities Research Center (IDDRC) is an interdisciplinary program with the overarching goal of supporting and promoting research relevant to understanding the pathogenesis and treatment of neurodevelopmental disorders. The UNC IDDRC is a critical component of the new Carolina Institute for Developmental Disabilities (CIDD), which is the focal point for clinical services, research, and training relevant to intellectual and developmenta disabilities (IDDs) on the UNC campus. The UNC IDDRC currently supports 39 investigators from 16 University departments, and includes 67 externally-funded research projects. The broad-based research program of this IDDRC is integrated around 3 themes: (1) Autism and Related Neurodevelopmental Disorders; (2) Brain and Behavior Development; and, (3) Early Detection/Intervention. The UNC IDDRC is a highly collaborative program highlighted by the presence of several NIH-funded, interdisciplinary research centers/programs. This application seeks support for: (1) an Administrative Core; (2) three research cores - a Clinical Translational Core, which includes the Research Participant Registry and Brain Measurement Laboratory; a Preclinical Core, which includes the Mouse Behavioral Phenotyping, Brain Imaging Analysis, and Confocal/Multiphoton Microscopy Labs; and the Bioinformatics/Biostatistics Core; and (3) a preclinical/clinical research project entitled "Neural Circuit Regulation of Social Reward Motivation" potentially providing important new information related to novel therapeutic targets for normalizing social behavior in individuals with ASD. The three proposed research cores provide cutting-edge, high-quality and cost effective support for this integrated, multidisciplinar, translational program of IDD-relevant research. Overall, this Center has had a major impact on developmental disabilities research and scientific training at the University of North Carolina, and renewal would allow us to continue our support of the truly exceptional program of IDD research conducted at UNC.