Clinical Translational Research Center for Neurodevelopmental Disorders

描述（由申请人提供）：北卡罗来纳大学智力与发育障碍研究中心 (IDDRC) 是一个跨学科项目，其总体目标是支持和促进与了解神经发育障碍的发病机制和治疗相关的研究。北卡罗来纳大学 IDDRC 是新成立的卡罗莱纳发育障碍研究所 (CIDD) 的重要组成部分，该研究所是北卡罗来纳大学校园内与智力和发育障碍 (IDD) 相关的临床服务、研究和培训的焦点。北卡罗来纳大学 IDDRC 目前支持来自 16 个大学系的 39 名研究人员，包括 67 个外部资助的研究项目。 IDDRC 基础广泛的研究项目围绕 3 个主题进行整合：(1) 自闭症和相关神经发育障碍； (2) 大脑和行为发育； (3) 早期检测/干预。北卡罗来纳大学 IDDRC 是一个高度协作的项目，其特点是存在多个由 NIH 资助的跨学科研究中心/项目。本申请寻求支持： (1) 管理核心； （2）三个研究核心——临床转化核心，包括研究参与者登记处和脑测量实验室；临床前核心，包括小鼠行为表型、脑成像分析和共焦/多光子显微镜实验室；和生物信息学/生物统计学核心； (3) 题为“社会奖励动机的神经回路调节”的临床前/临床研究项目可能提供与自闭症谱系障碍患者社会行为正常化的新治疗目标相关的重要新信息。拟议的三个研究核心为 IDD 相关研究的综合、多学科、转化计划提供尖端、高质量和成本效益的支持。总体而言，该中心对北卡罗来纳大学的发育障碍研究和科学培训产生了重大影响，更新将使我们能够继续支持北卡罗来纳大学开展的真正特殊的 IDD 研究计划。

DESCRIPTION (provided by applicant): The University of North Carolina Intellectual and Developmental Disabilities Research Center (IDDRC) is an interdisciplinary program with the overarching goal of supporting and promoting research relevant to understanding the pathogenesis and treatment of neurodevelopmental disorders. The UNC IDDRC is a critical component of the new Carolina Institute for Developmental Disabilities (CIDD), which is the focal point for clinical services, research, and training relevant to intellectual and developmenta disabilities (IDDs) on the UNC campus. The UNC IDDRC currently supports 39 investigators from 16 University departments, and includes 67 externally-funded research projects. The broad-based research program of this IDDRC is integrated around 3 themes: (1) Autism and Related Neurodevelopmental Disorders; (2) Brain and Behavior Development; and, (3) Early Detection/Intervention. The UNC IDDRC is a highly collaborative program highlighted by the presence of several NIH-funded, interdisciplinary research centers/programs. This application seeks support for: (1) an Administrative Core; (2) three research cores - a Clinical Translational Core, which includes the Research Participant Registry and Brain Measurement Laboratory; a Preclinical Core, which includes the Mouse Behavioral Phenotyping, Brain Imaging Analysis, and Confocal/Multiphoton Microscopy Labs; and the Bioinformatics/Biostatistics Core; and (3) a preclinical/clinical research project entitled "Neural Circuit Regulation of Social Reward Motivation" potentially providing important new information related to novel therapeutic targets for normalizing social behavior in individuals with ASD. The three proposed research cores provide cutting-edge, high-quality and cost effective support for this integrated, multidisciplinar, translational program of IDD-relevant research. Overall, this Center has had a major impact on developmental disabilities research and scientific training at the University of North Carolina, and renewal would allow us to continue our support of the truly exceptional program of IDD research conducted at UNC.