IBR COBRE ADMINISTRATIVE CORE

IBR COBRE 管理核心

• 批准号: 8360318
• 负责人: WILLIAM S WARD
• 金额: $ 39.26万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8360318
• 关键词: Academy; Biogenesis; Burn injury; Centers of Research Excellence; Child; Clinical; Clinical Research; Cloning; Congenital Abnormality; Data; Development; Discipline of obstetrics; Embryonic Development; Event; Faculty; Fertilization in Vitro; Funding; Goals; Grant; Gynecology; Hawaii; Infertility; Institutes; Intracytoplasmic Sperm Injections; Mammals; Mediating; Molecular; National Center for Research Resources; Principal Investigator; Reproduction; Reproductive Biology; Reproductive Health; Research; Research Design; Research Infrastructure; Research Institute; Research Personnel; Resources; Science; Source; Staging; Transgenic Mice; Translational Research; United States National Institutes of Health; Universities; cost; design; innovation; medical schools; member; translational study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of COBRE is to transform the existing Institute for Biogenesis Research (IBR) at the John A. Burns School of Medicine (JABSOM) in the University of Hawaii at M
noa (UH-M
noa) into an interdisciplinary, translational research institute for reproductive biology. The IBR was established in 1999 by the State of Hawaii. Its founding rationale was to continue the legacy of reproductive biology research pioneered by National Academy member Dr. Ryuzo Yanagimachi. His team produced major breakthroughs in reproductive biology, including the development of intracytoplasmic sperm injection (ICSI), the principles underlying in vitro fertilization (IVF) in mammals, the first demonstration of repetitive mammalian cloning, and ICSI-mediated transgenic mice. The IBR's research focus lies in early molecular events in mammalian embryogenesis and their effects on later stages of development. This COBRE supports five junior investigators whose research expertise is directly related to the IBR's research focus, and the creation of a Transgenic Mouse Core. Through partnership with the Pacific IVF Institute and the clinical Department of Obstetrics and Gynecology, we will support translational projects designed to advance the science of reproduction and reduce both infertility and birth defects for children. We seek to accomplish these objectives through the following specific aims: 1) the IBR COBRE will contribute to infrastructure at UH-M
noa by enhancing Core resources available for investigators across campus, and 2) the IBR COBRE will support talented junior faculty toward independence as they conduct innovative basic, clinical and translational studies designed to produce data relevant to reproductive health.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 COBRE 的目标是将夏威夷大学 M noa (UH-M noa) 约翰 A. 伯恩斯医学院 (JABSOM) 现有的生物发生研究所 (IBR) 改造成一个跨学科、转化性的生殖生物学研究所。 IBR 由夏威夷州于 1999 年成立。其成立的理由是延续国家科学院院士柳町龙三博士开创的生殖生物学研究遗产。他的团队在生殖生物学方面取得了重大突破，包括胞浆内单精子注射 (ICSI) 的发展、哺乳动物体外受精 (IVF) 的基本原理、首次演示哺乳动物重复克隆以及 ICSI 介导的转基因小鼠。 IBR 的研究重点在于哺乳动物胚胎发生的早期分子事件及其对发育后期的影响。 该 COBRE 支持五名初级研究人员，他们的研究专业知识与 IBR 的研究重点以及转基因小鼠核心的创建直接相关。通过与太平洋试管婴儿研究所和妇产科临床部门合作，我们将支持旨在推进生殖科学并减少儿童不孕症和出生缺陷的转化项目。我们力求通过以下具体目标来实现这些目标：1) IBR COBRE 将通过增强校园内研究人员可用的核心资源，为 UH-M noa 的基础设施做出贡献；2) IBR COBRE 将支持有才华的初级教师走向独立，因为他们进行创新的基础、临床和转化研究，旨在产生与生殖健康相关的数据。