New York Regional Center for Diabetes Translation Research - Life Course Methodology Core

生命历程方法论核心(LCMC) 纽约区域中心终身课程方法核心(LCMC)的总体目标 糖尿病翻译研究旨在支持糖尿病预防领域的高质量II型翻译研究 以及对整个生命周期的控制。生命过程视角侧重于生物、心理、社会和行为 个人在其生命中的特定时期经历的过程，并考察了 这些暴露在塑造疾病风险方面。目前，从观测研究中有强有力的证据表明 导致糖尿病发展的过程在生命早期就开始了，并持续到整个生命周期。这 生命过程方法还可以通过确保有效干预措施的转化 干预策略适用于目标年龄组，并针对相关的个人或 环境障碍。遵循这一思路，我们提出了一种双管齐下的方法，以确定 考虑到生命阶段的最相关的可改变的风险因素和最适当的干预措施 有针对性的。中心将利用现有的多学科专业知识和基础设施，以促进应用 对新的II型转换性糖尿病研究的生命历程的看法。爱因斯坦研究人员和他们的 合作者在糖尿病研究方面积累了数十年的专业知识，并表现良好 定位为促进翻译研究的加速。该中心将提供概念性和 关于设计和实施新的II型转化型糖尿病研究的工具支持 终生以减轻糖尿病负担和缓解糖尿病健康为最终目标 差距。康乐及文化事务署的具体目标是：1)促进将生命历程方法应用于 新型II型转化型糖尿病研究设计。康乐及文化事务署提供谘询及技术支援，以 转化型糖尿病研究中的临床研究人员，包括检查相互依赖的因素 使个人面临患糖尿病的风险，特别强调健康差距。我们支持这样的研究 确定生命周期内关键易损期的可修改风险因素，这些因素可用于 制定预防和治疗干预措施，以减少糖尿病及其并发症。2)至 通过提供以下专业知识，优化新型II型翻译干预研究的实施 将方法与干预措施所针对的特定生命阶段(S)相匹配。该中心提供了一个 具有专业知识的调查人员协作平台，范围从幼儿到老年人，再到 协助调查人员实施转化性干预研究。3)提供基础设施 为设计和执行II型转化型糖尿病的终身研究提供 试验数据和确定研究参与者的资源。

Life Course Methodology Core (LCMC) The overall goal of the Life Course Methodology Core (LCMC)of the New York Regional Center for Diabetes Translation Research is to support high quality type II translational research in diabetes prevention and control across the life span. The life course perspective focuses on the biopsychosocial and behavioral processes that individuals experience during particular periods in their life, and examines the interplay between these exposures in shaping disease risk. Currently, there is strong evidence from observational studies that the processes that lead to the development of diabetes start early in life and continue throughout the lifespan. This Life Course approach also can enhance the translation of efficacious interventions by ensuring that intervention strategies are appropriate for the age group targeted and address the associated individual or environmental barriers. Following this line of thought, we propose a two pronged approach that identifies the most relevant modifiable risk factors and the most appropriate interventions taking into account the life stage targeted. The LCMC will leverage existing multidisciplinary expertise and infrastructure to facilitate application of a life course perspective to new type II translational diabetes research. Einstein investigators and their collaborators have accumulated decades of expertise in diabetes research across the life span and are well positioned to contribute to the acceleration of translational research. The LCMC will provide conceptual and instrumental support regarding the design, and implementation of new type II translational diabetes research across the life span with the ultimate goal of decreasing the burden of diabetes and alleviating diabetes health disparities. The LCMC specific aims are: 1) To facilitate the application of the life course approach to the design of new type II translational diabetes research. LCMC provides consultation and technical support to clinical investigators in translational diabetes research that includes examining the interdependent factors that put individuals at risk of diabetes, with special emphasis in health disparities. We support research that identifies modifiable risk factors at critical vulnerable periods over the life span that could be used in the development of prevention and treatment interventions to reduce diabetes and its complications. 2) To optimize the implementation of new type II translational intervention research by providing expertise that will match methodologies to the specific life stage(s) targeted by the interventions. The LCMC provides a collaborative platform of investigators with expertise that ranges from early childhood to elderly population to assist investigators with the implementation of translational intervention research. 3) To provide infrastructure for the design and execution of type II translational diabetes research across the life span by providing resources for pilot data and for identification of study participants.