Pain and Neurodegenerative Undergraduate Research Experiences: Interacting with community partners to build specialized and enhanced neurologic disease programs for undergraduates.
疼痛和神经退行性本科生研究经验:与社区合作伙伴互动,为本科生建立专门和增强的神经系统疾病项目。
基本信息
- 批准号:10318168
- 负责人:
- 金额:$ 10.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-01-01 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:AffectAgeAreaAtmosphereAttitudeBasic ScienceBiochemistryBiologyBiomedical EngineeringBiomedical ResearchBudgetsChemistryChronicClimateClinicClinicalClinical ResearchCommunitiesCountryDataDevelopmentDiseaseEducational workshopEmpathyEnsureEthicsExposure toFirst Generation College StudentsFundingGenerationsGoalsHispanic-serving InstitutionHistorically Black Colleges and UniversitiesIndividualInstitutionInterviewJournalsNerve DegenerationNeurodegenerative DisordersNeurologyNeurosciencesOccupational TherapyOralPainPain ResearchPatientsPharmacologyPharmacy facilityPhysical therapyPhysiciansPhysicsPopulationPopulation HeterogeneityProcessProductivityPsychologyPublic HealthResearchResearch PersonnelSafetyScienceScientistSiteStudent recruitmentStudentsTimeTrainingTravelUnderrepresented MinorityUnderrepresented PopulationsUnited States National Institutes of HealthUniversitiesVisitWorkWritingcareercareer developmentchronic neurologic diseasechronic painchronic pain managementchronic pain patientchronic painful conditioncomputer sciencecurriculum developmentdesignexperienceimprovedinterestmembernervous system disorderprogramsrecruitsequence learningsummer programsummer researchsymposiumundergraduate research experienceundergraduate student
项目摘要
PROJECT SUMMARY
In the last decade, due to Congressional budget cuts, NIH funding for biomedical research has plummeted
despite a growing public health need. Beyond the obvious effect of this reduction on the productivity of
research labs, this funding climate likely dissuades undergraduate students from pursuing careers in
biomedical research. This effect will be particularly deleterious to the study and understanding of chronic
neurologic disease, an area of growing concern. We aim to counteract this possibility by supporting specialized
summer undergraduate research experiences in pain and neurodegenerative disease. The rationale for this
proposal is that by strengthening undergraduate research programs in neurologic disease, we can begin to
build a pipeline of skilled researchers to respond to increasing rates of neurodegenerative diseases as our
population ages. This proposal aims to develop and continue to implement two synergistic biomedical research
programs. These new programs, the Pain Undergraduate Research Experience (PURE) and
Neurodegenerative Undergraduate Research Experience (NURE), are cross-disciplinary and community-
engaged biomedical summer undergraduate research programs. The objective of the PURE and NURE
summer program is to increase student understanding of and exposure to the underlying science of pain and
neurodegeneration, and importantly, to offer a more complete and authentic experience, by bridging basic
science research with opportunities for students to interact on- and off-site with clinical researchers. 12 (six per
program) rising sophomores and above will be recruited each summer for a 10-week long PURE or NURE
session. We anticipate recruiting students from a variety of undergraduate majors including biology, chemistry,
biochemistry, pre-physical therapy, pre-occupational therapy, pre-pharmacy, neuroscience, physics, computer
science, and biomedical engineering. [We aim to include a diverse population of students by recruiting
nationally from large research universities, historically black colleges and universities, Hispanic-serving
institutions, and regionally from low research and primarily undergraduate institutions.]
项目总结
在过去的十年里,由于国会预算削减,美国国立卫生研究院对生物医学研究的资金大幅下降
尽管公共卫生需求日益增长。除了这种削减对生产力的明显影响之外,
研究实验室,这种资金环境可能会阻止本科生在
生物医学研究。这种影响将特别不利于对慢性阻塞性肺疾病的研究和理解
神经疾病,一个日益令人担忧的领域。我们旨在通过支持专业人员来抵消这种可能性
夏季本科生在疼痛和神经退行性疾病方面的研究经验。这样做的理由是
建议通过加强神经系统疾病的本科生研究项目,我们可以开始
建立一个熟练的研究人员管道,以应对日益增长的神经退行性疾病,因为我们的
人口老龄化。这项建议旨在发展并继续实施两项协同生物医学研究
程序。这些新项目,疼痛本科生研究体验(PURE)和
神经退行性本科生研究体验(Nure),是跨学科和社区-
参与生物医学暑期本科生研究项目。《纯洁与纯真》的目标
暑期计划旨在增加学生对疼痛和疼痛的基本科学的了解和接触
神经退化,更重要的是,通过连接基本的
科学研究,为学生提供与临床研究人员进行现场和非现场互动的机会。12(6%)
计划)每年夏天将招募二年级及以上的学生参加为期10周的纯洁或纯真课程
会议。我们预计将招收各种本科专业的学生,包括生物、化学、
生物化学、物理治疗前、职业前治疗、制药前、神经科学、物理学、计算机
科学和生物医学工程。[我们的目标是通过招收不同类型的学生
在全国范围内,从大型研究型大学、历史上的黑人学院和大学,到拉美裔服务
来自研究水平较低的机构,主要是本科院校。]
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Extracellular Vesicles Derived from a Human Brain Endothelial Cell Line Increase Cellular ATP Levels.
- DOI:10.1208/s12249-020-01892-w
- 发表时间:2021-01-03
- 期刊:
- 影响因子:3.3
- 作者:Dave KM;Zhao W;Hoover C;D'Souza A;S Manickam D
- 通讯作者:S Manickam D
Modeling Neural Behavior and Pain During Bladder Distention using an Agent-based Model of the Central Nucleus of the Amygdala
使用基于代理的杏仁核中央核模型对膀胱扩张期间的神经行为和疼痛进行建模
- DOI:10.30707/spora
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Joshua Baktay;R. Neilan;M. Behun;Neal McQuaid;B. Kolber
- 通讯作者:B. Kolber
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
MICHAEL CASCIO其他文献
MICHAEL CASCIO的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('MICHAEL CASCIO', 18)}}的其他基金
Photoprobes for identifying potential anti-depressant and anti-anxiety medication
用于识别潜在抗抑郁和抗焦虑药物的光探针
- 批准号:
8511056 - 财政年份:2013
- 资助金额:
$ 10.8万 - 项目类别:
Photoprobes for identifying potential anti-depressant and anti-anxiety medication
用于识别潜在抗抑郁和抗焦虑药物的光探针
- 批准号:
8653024 - 财政年份:2013
- 资助金额:
$ 10.8万 - 项目类别:
MODELING OF NEUROTRANSMITTER GATED CHANNELS & RECEPTORS & RELATED PROTEINS
神经递质门控通道的建模
- 批准号:
6221097 - 财政年份:1999
- 资助金额:
$ 10.8万 - 项目类别:
MODELING OF NEUROTRANSMITTER GATED CHANNELS, RECEPTORS, PROTEINS: STRUC & FUNCT
神经递质门控通道、受体、蛋白质的建模:STRUC
- 批准号:
6122477 - 财政年份:1998
- 资助金额:
$ 10.8万 - 项目类别:
MODELING OF NEUROTRANSMITTER GATED CHANNELS, RECEPTORS, PROTEINS: STRUC & FUNCT
神经递质门控通道、受体、蛋白质的建模:STRUC
- 批准号:
6282512 - 财政年份:1998
- 资助金额:
$ 10.8万 - 项目类别:
MODELING OF NEUROTRANSMITTER GATED CHANNELS, RECEPTORS, PROTEINS: STRUC & FUNCT
神经递质门控通道、受体、蛋白质的建模:STRUC
- 批准号:
6295167 - 财政年份:1998
- 资助金额:
$ 10.8万 - 项目类别:
STRUCT FUNCT OF NEUROTRANSMITTER GATED CHANNELS & RECEPTORS & RELATED PROTEINS
神经递质门控通道的结构功能
- 批准号:
6253457 - 财政年份:1997
- 资助金额:
$ 10.8万 - 项目类别:
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Holocene Landscape History in the forest area „Schweinert“ – a geoarchaeological study in Germany’s largest Bronze Age barrow cemetery
森林地区全新世景观历史“Schweinert”——德国最大的青铜时代手推墓地的地质考古研究
- 批准号:
452251818 - 财政年份:2020
- 资助金额:
$ 10.8万 - 项目类别:
Research Grants
Empirical study on the Iron Production of the Early Iron Age in the Area of Altai Extending over Four Countries
阿尔泰地区四国早期铁器时代铁矿生产实证研究
- 批准号:
17H01646 - 财政年份:2017
- 资助金额:
$ 10.8万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Religious Paracelsianism: Science and Religion in the German-speaking Area of the Early Modern Age
宗教帕拉塞尔西主义:近代早期德语区的科学与宗教
- 批准号:
16K21332 - 财政年份:2016
- 资助金额:
$ 10.8万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Age and significance of permafrost landforms in the Fort McMurray area
麦克默里堡地区多年冻土地貌的年龄和意义
- 批准号:
478568-2015 - 财政年份:2015
- 资助金额:
$ 10.8万 - 项目类别:
University Undergraduate Student Research Awards
Late Neolithic/Early Bronze Age developments in the south-west Baltic area (2500-1500 BC): Why did the Bruszczewo-Leki Male type of power structures appear?
波罗的海西南部地区新石器时代晚期/青铜时代早期的发展(公元前2500-1500年):为什么会出现布鲁什切沃-莱基男性类型的权力结构?
- 批准号:
277223019 - 财政年份:2015
- 资助金额:
$ 10.8万 - 项目类别:
Research Grants
'Ritual feasting' in the Late Bronze Age in the northwestern Carpathian area -archaeological and scientific aspects
喀尔巴阡山脉西北部地区青铜时代晚期的“仪式盛宴”——考古和科学方面
- 批准号:
287419687 - 财政年份:2015
- 资助金额:
$ 10.8万 - 项目类别:
Research Grants
Research on the Folk House of Yeosu Area in a Modern Age -Consideration from a Viewpoint of the Influence of the Ocean Culture Area-
近代丽水地区民居研究-从海洋文化区影响的角度思考-
- 批准号:
26420607 - 财政年份:2014
- 资助金额:
$ 10.8万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A study about the age and the production area of the Yan Guo and Liaoning Area Remains in the Spring and Autumn Warring States Period
春秋战国时期燕国及辽宁地区遗存的年代及产地研究
- 批准号:
25300043 - 财政年份:2013
- 资助金额:
$ 10.8万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
The formation process of Tai Hang mountains area in Final stage of Chinese Neolithic age : Focused on analysing pottery
中国新石器时代末期大坑山区的形成过程——以陶器为重点分析
- 批准号:
23820059 - 财政年份:2011
- 资助金额:
$ 10.8万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Bronze Age Carian Iasos: Structures, Stratigraphy, and Finds from the area of the Late Roman Agora (ca. 3000-1500 BC)
青铜时代卡里安亚索斯:晚期罗马集市(约公元前 3000-1500 年)地区的结构、地层学和发现物
- 批准号:
AH/I001611/1 - 财政年份:2011
- 资助金额:
$ 10.8万 - 项目类别:
Fellowship














{{item.name}}会员




