Phase 2 Enhancement of Outdoor Group Housing for U42 SPF 9 Rhesus Macaques

U42 SPF 9 恒河猴户外群舍第二期强化工程

• 批准号: 10360780
• 负责人: Michael K Axthelm
• 金额: $ 50万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10360780
• 关键词: AIDS vaccine development; AIDS-Related Opportunistic Infections; Acquired Immunodeficiency Syndrome; Address; Adult; Adult Children; Animal Husbandry; Animal Welfare; Animals; Area; Breeding; Clinical; Development; Environmental Protection; Female; Floor; Funding; Genetic; Goals; Health Sciences; Housing; Individual; Infant; Infrastructure; Lymphocryptovirus; Macaca; Macaca mulatta; Modification; Oregon; Phase; Population; Primates; Procedures; Production; Request for Applications; Research; Shelter facility; Social Welfare; Solid; Source; Structure; Universities; Viral; Water; Weather; animal breeding; animal care; design; flexibility; improved; male; man; mature animal; offspring; prevent; recruit; seroconversion; social; social group; square foot; symposium; transmission process; vector vaccine

PROJECT SUMMARY The Oregon National Primate Research Center (ONPRC) Expanded SPF (ESPF) Rhesus Macaque Breeding Colony is a highly specialized breeding colony that provides unique and essential macaques with an expanded SPF definition for AIDS research. This colony is critical for AIDS-related opportunistic infection research and vaccine vector development using opportunistic viral agents as vaccine vectors. In order to provide a sufficient number of appropriate animals, the breeding colony must produce 30 surplus animals annually. Concurrently, it is necessary to isolate lymphocryptovirus (LCV) free animals and re-derive LCV-free offspring from LCV seroconverted females in the colony and recruit additional LCV-free infants from Center's convention SPF colony. A critical shortage of appropriate ESPF social housing severely constrain both our efforts to increase the size of the breeding colony to meet project demand and our endeavors to eliminate LCV from the colony. The application proposes to complete modifications of the existing southwest outdoor sheltered housing structure providing an additional four 500 sq. ft. social housing units. The proposed modifications would expand the total number of outdoor ESPF breeding animals housed in social groups permitting increased production, facilitate genetic management by providing smaller housing units that are more appropriate for housing 7-10 females and a male and offspring, provide sufficient separation between individual housing units to prevent transmission of agents between groups, and improve animal welfare through social housing.

项目摘要 俄勒冈州国家灵长类动物研究中心（ONPRC）扩大SPF（ESPF）恒河猴繁殖 殖民地是一个高度专业化的繁殖殖民地，提供独特的和必要的猕猴与扩大 艾滋病研究的SPF定义。该菌落对于艾滋病相关机会性感染研究至关重要， 使用机会性病毒因子作为疫苗载体的疫苗载体开发。为了提供足够的 为了确保适当的动物数量，繁殖群体必须每年生产30只剩余动物。同时，它 是分离无淋巴隐病毒（LCV）动物和从LCV再衍生无LCV后代所必需的 殖民地中血清转化的雌性，并从中心的常规SPF中招募额外的无LCV的婴儿 殖民地适当的ESPF社会住房严重短缺，严重制约了我们增加 满足项目需求的繁殖群体的大小，以及我们努力消除殖民地中的LCV。 该申请建议完成现有西南室外庇护住房的改造 提供额外四个500平方米的结构英尺社会住房单位。拟议的修改将 扩大在社会群体中饲养的户外ESPF繁殖动物的总数， 生产，通过提供更适合于 可容纳7-10只雌性和一只雄性及其后代，在各个住房单元之间提供足够的分隔 防止病原体在群体之间传播，并通过社会住房改善动物福利。