Novel Caging and Equipment to Enhance Social Interaction and Animal Wellbeing in U42 SPF9 Rhesus Macaques.

项目摘要 俄勒冈州国家灵长类动物研究中心（ONPRC）扩大SPF（ESPF）恒河猴繁殖 殖民地是一个高度专业化的繁殖殖民地，提供独特的和必要的猕猴与扩大 艾滋病研究的SPF定义。该菌落对于艾滋病相关机会性感染研究至关重要， 使用机会性病毒因子作为疫苗载体的疫苗载体开发。为了提供足够的 为了确保适当的动物数量，繁殖群体必须每年生产30只剩余动物。同时，它 是分离无淋巴隐病毒（LCV）动物和从LCV再衍生无LCV后代所必需的 殖民地中血清转化的雌性，并从中心的常规SPF中招募额外的无LCV的婴儿 殖民地适当的ESPF社会住房严重短缺，严重制约了我们增加 满足项目需求的繁殖群体的大小，以及我们努力消除殖民地中的LCV。 该申请建议购买新的笼子和隧道，以增加殖民地的基础设施， 在ESPF屏障圈养设施中圈养多只笼舍动物。加强社会住房 机会将有利于动物与现有的行为问题，提供更好的发展轨迹， 为招募到殖民地的婴儿，并促进积极的动物福利和健康，同时提供一个 ESPF人口扩张的途径，以跟上需求的步伐。该申请还建议购买 用于储存富集装置和动物转运箱的储存棚。这些项目是专门为 ESPF猕猴的独家支持，以最大限度地减少无意中损害动物ESPF的风险 status.

PROJECT SUMMARY The Oregon National Primate Research Center (ONPRC) Expanded SPF (ESPF) Rhesus Macaque Breeding Colony is a highly specialized breeding colony that provides unique and essential macaques with an expanded SPF definition for AIDS research. This colony is critical for AIDS-related opportunistic infection research and vaccine vector development using opportunistic viral agents as vaccine vectors. In order to provide a sufficient number of appropriate animals, the breeding colony must produce 30 surplus animals annually. Concurrently, it is necessary to isolate lymphocryptovirus (LCV) free animals and re-derive LCV-free offspring from LCV seroconverted females in the colony and recruit additional LCV-free infants from Center's conventional SPF colony. A critical shortage of appropriate ESPF social housing severely constrain both our efforts to increase the size of the breeding colony to meet project demand and our endeavors to eliminate LCV from the colony. The application proposes to purchase novel caging and a tunnel to increase the colonies infrastructure for housing multiple cage-housed animals in the ESPF barrier housing facility. Enhancing social housing opportunities will benefit animals with existing behavioral problems, provide better developmental trajectories for infants recruited to the colony, and promote positive animal welfare and health, all while providing an avenue for ESPF population expansion to keep pace with demand. The application also proposes to purchase a storage shed for storing enrichment devices and animals transfer boxes. These items are dedicated for the exclusive support of ESPF macaques to minimize the risk of inadvertently compromising the animals ESPF status.