Novel Caging and Equipment to Enhance Social Interaction and Animal Wellbeing in U42 SPF9 Rhesus Macaques.

新型笼具和设备可增强 U42 SPF9 恒河猴的社交互动和动物福祉。

• 批准号: 10404873
• 负责人: Michael K Axthelm
• 金额: $ 49.98万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10404873
• 关键词: AIDS vaccine development; AIDS-Related Opportunistic Infections; Acquired Immunodeficiency Syndrome; Animal Housing; Animal Welfare; Animals; Area; Attention; Award; Breeding; Clinic; Custom; Development; Devices; Equipment; Female; Funding; Goals; Health; Health Sciences; Height; Housing; Infant; Infrastructure; Lymphocryptovirus; Macaca; Macaca mulatta; Oregon; Parents; Personal Satisfaction; Phase; Population; Primates; Problem behavior; Procedures; Production; Productivity; Request for Applications; Research; Resources; Shelter facility; Social Interaction; Social support; Socialization; Structure; Support Groups; System; Universities; Vaccine Research; Viral; Zoonoses; animal breeding; design; enzootic; improved; innovation; novel; offspring; prevent; recruit; research and development; risk minimization; social; square foot; transmission process; vector vaccine; welfare

PROJECT SUMMARY The Oregon National Primate Research Center (ONPRC) Expanded SPF (ESPF) Rhesus Macaque Breeding Colony is a highly specialized breeding colony that provides unique and essential macaques with an expanded SPF definition for AIDS research. This colony is critical for AIDS-related opportunistic infection research and vaccine vector development using opportunistic viral agents as vaccine vectors. In order to provide a sufficient number of appropriate animals, the breeding colony must produce 30 surplus animals annually. Concurrently, it is necessary to isolate lymphocryptovirus (LCV) free animals and re-derive LCV-free offspring from LCV seroconverted females in the colony and recruit additional LCV-free infants from Center's conventional SPF colony. A critical shortage of appropriate ESPF social housing severely constrain both our efforts to increase the size of the breeding colony to meet project demand and our endeavors to eliminate LCV from the colony. The application proposes to purchase novel caging and a tunnel to increase the colonies infrastructure for housing multiple cage-housed animals in the ESPF barrier housing facility. Enhancing social housing opportunities will benefit animals with existing behavioral problems, provide better developmental trajectories for infants recruited to the colony, and promote positive animal welfare and health, all while providing an avenue for ESPF population expansion to keep pace with demand. The application also proposes to purchase a storage shed for storing enrichment devices and animals transfer boxes. These items are dedicated for the exclusive support of ESPF macaques to minimize the risk of inadvertently compromising the animals ESPF status.

项目总结 俄勒冈州国家灵长类研究中心(ONPRC)扩大了SPF(ESPF)猕猴的繁殖 蜂群是一个高度专业化的繁殖群体，为独特而必要的猕猴提供了一个扩展的 艾滋病研究的SPF定义。这个群体对于艾滋病相关的机会性感染研究和 使用机会性病毒制剂作为疫苗载体的疫苗载体的开发。为了提供足够的 适当的动物数量，繁殖群体每年必须生产30只多余的动物。同时，它还 是分离无淋巴腺病毒(LCV)的动物和从LCV中重新获得无LCV的后代所必需的 在群体中招募血清转换的雌性，并从中心的常规SPF招募额外的无LCV婴儿 殖民地。严重缺乏适当的ESPF社会住房严重制约了我们增加 繁殖群体的规模，以满足项目需求和我们从群体中消除LCV的努力。 应用程序建议购买新的笼子和隧道，以增加殖民地基础设施 在ESPF屏障住房设施中安置多只笼养动物。加强社会保障住房建设 机会将使有现有行为问题的动物受益，提供更好的发育轨迹 对于被招募到殖民地的婴儿，并促进积极的动物福利和健康，同时提供 用于ESPF人口扩张的大道，以跟上需求的步伐。该应用程序还建议购买 用来存放浓缩装置和动物转运箱的储藏室。这些物品是专门为 独家支持ESPF猕猴，将无意中危害动物ESPF的风险降至最低 状态。