Novel Caging and Equipment to Enhance Social Interaction and Animal Wellbeing in U42 SPF9 Rhesus Macaques.

新型笼具和设备可增强 U42 SPF9 恒河猴的社交互动和动物福祉。

• 批准号: 10404873
• 负责人: Michael K Axthelm
• 金额: $ 49.98万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10404873
• 关键词: AIDS vaccine development; AIDS-Related Opportunistic Infections; Acquired Immunodeficiency Syndrome; Animal Housing; Animal Welfare; Animals; Area; Attention; Award; Breeding; Clinic; Custom; Development; Devices; Equipment; Female; Funding; Goals; Health; Health Sciences; Height; Housing; Infant; Infrastructure; Lymphocryptovirus; Macaca; Macaca mulatta; Oregon; Parents; Personal Satisfaction; Phase; Population; Primates; Problem behavior; Procedures; Production; Productivity; Request for Applications; Research; Resources; Shelter facility; Social Interaction; Social support; Socialization; Structure; Support Groups; System; Universities; Vaccine Research; Viral; Zoonoses; animal breeding; design; enzootic; improved; innovation; novel; offspring; prevent; recruit; research and development; risk minimization; social; square foot; transmission process; vector vaccine; welfare

PROJECT SUMMARY The Oregon National Primate Research Center (ONPRC) Expanded SPF (ESPF) Rhesus Macaque Breeding Colony is a highly specialized breeding colony that provides unique and essential macaques with an expanded SPF definition for AIDS research. This colony is critical for AIDS-related opportunistic infection research and vaccine vector development using opportunistic viral agents as vaccine vectors. In order to provide a sufficient number of appropriate animals, the breeding colony must produce 30 surplus animals annually. Concurrently, it is necessary to isolate lymphocryptovirus (LCV) free animals and re-derive LCV-free offspring from LCV seroconverted females in the colony and recruit additional LCV-free infants from Center's conventional SPF colony. A critical shortage of appropriate ESPF social housing severely constrain both our efforts to increase the size of the breeding colony to meet project demand and our endeavors to eliminate LCV from the colony. The application proposes to purchase novel caging and a tunnel to increase the colonies infrastructure for housing multiple cage-housed animals in the ESPF barrier housing facility. Enhancing social housing opportunities will benefit animals with existing behavioral problems, provide better developmental trajectories for infants recruited to the colony, and promote positive animal welfare and health, all while providing an avenue for ESPF population expansion to keep pace with demand. The application also proposes to purchase a storage shed for storing enrichment devices and animals transfer boxes. These items are dedicated for the exclusive support of ESPF macaques to minimize the risk of inadvertently compromising the animals ESPF status.

项目概要 俄勒冈国家灵长类研究中心 (ONPRC) 扩大 SPF (ESPF) 恒河猴育种 Colony 是一个高度专业化的繁殖群，为独特而重要的猕猴提供了扩展的 艾滋病研究的 SPF 定义。该菌落对于艾滋病相关的机会性感染研究和研究至关重要 使用机会病毒剂作为疫苗载体开发疫苗载体。为了提供足够的 适当的动物数量，繁殖群体每年必须生产 30 只剩余动物。同时，它 有必要分离无淋巴隐病毒 (LCV) 的动物并从 LCV 中重新衍生出无 LCV 的后代 在群体中进行血清转化的雌性，并从中心的传统 SPF 中招募额外的无 LCV 的婴儿 殖民地。适当的 ESPF 社会住房的严重短缺严重限制了我们增加收入的努力 满足项目需求的繁殖群体规模以及我们消除群体中 LCV 的努力。 该申请建议购买新型笼子和隧道，以增加蜂群基础设施 在 ESPF 屏障饲养设施中饲养多只笼养动物。加强社会住房 机会将使存在行为问题的动物受益，提供更好的发展轨迹 为招募到殖民地的婴儿提供帮助，促进积极的动物福利和健康，同时提供 ESPF 人口扩张以满足需求的途径。该申请还建议购买 用于存放浓缩装置和动物转移箱的储藏棚。这些物品专门用于 独家支持 ESPF 猕猴，最大限度降低无意中损害动物 ESPF 的风险 地位。