Nonhuman Primate Core
Nonhuman Primate Core
批准号:
8376405
负责人:
Michael K Axthelm
金额:
$50.1万
依托单位国家:
美国
项目类别:
财政年份:
2012
资助国家:
美国
项目状态:
已结题
起止时间:
2012-03-01 至 2014-02-28
关键词:
Animal ExperimentationAnimal ModelAnimalsAutopsyBiomedical ResearchBody CompositionCenters of Research ExcellenceCercopithecidaeClinicalClinical ManagementCompetenceComplexCost SavingsDataDengueDrug or chemical Tissue DistributionEbola virusEmerging Communicable DiseasesEvaluationFrankfurt-Marburg Syndrome VirusGeneticGoalsHumanImmune systemImmunologicsImmunologyInfectious AgentInfectious Diseases ResearchInfluenzaInfluenza A Virus, H5N1 SubtypeInvestigationJunin virusLaboratoriesLaboratory PersonnelLifeMetabolismModelingMonitorMonkeypox virusOregonPacific NorthwestPathogenesisPathologicPhysiologicalPrimatesReproductionResearchResearch InfrastructureResourcesSafetyServicesSpecimen HandlingStructureTechnical ExpertiseTissue BankingTissue BanksTissue SampleTrainingVirusWashingtonWest Nile virusYellow fever virusanimal breedinganimal resourcecomparativeefficacy testinghuman diseaseinfrastructure developmentmeetingsmembernonhuman primateperformance siteresearch and developmentresearch facilitysafety studysample collectionvaccine development
中文摘要
非人类灵长类动物(NHP)核心是一个多中心的核心结构,以提供太平洋西北部
区域卓越中心(PNWRCE),拥有专门饲养动物的资源和独特的设施
以及传染病研究的专业调查和技术专长,
使用NHP。The Core的表演场地包括俄勒冈州和华盛顿国家灵长类动物园
研究中心(ONPRC比弗顿,OR和WaNPRC,西雅图,WA)和综合研究中心
位于落基山实验室(RML)园区(汉密尔顿,MT)的IRF设施。非人类灵长类动物
它们是独特的长寿物种,与人类有许多生理相似之处。这些相似之处包括
身体组成、成熟、繁殖、代谢和密切的遗传关系。现有的国家卫生方案
在研究中,旧大陆的猴子物种与人类有着最密切的进化关系,
生物医学研究的基本替代品,重点是缺乏适当的人类疾病,
替代动物模型。NHP免疫系统的组织和功能与
人类及其对理解不同文明之间复杂的相互关系的贡献
免疫系统的组成部分在防御传染性病原体中的作用尤其显著。
长期以来,非人灵长类动物被认为是人类疫苗的比较模型
开发、功效测试和安全性评价,以及研究
基础免疫学这些模型中的许多已被证明是致病机制研究和疫苗的价值
发展以遏制新出现和重新出现的传染病,H5 N1和1918年流感(1-3),
埃博拉和马尔堡病毒(4)、猴痘病毒(5、6)、西尼罗河病毒(7、8)、朱宁病毒(9)、黄热病
病毒和登革热病毒(10,11)。尽管它们具有研究价值,但NHP是复杂的,
在研究环境中,需要专门知识、基础设施和工作人员的物种。
英文摘要
The Nonhuman Primate (NHP) Core is a multicenter Core structured to provide the Pacific Northwest
Regional Center of Excellence (PNWRCE) with resources for purpose-bred animals and unique facilities
and specialized investigative and technical expertise for infectious disease research that is best conducted
using NHPs. The Core's performance sites include the Oregon and Washington National Primate
Research Centers (ONPRC Beaverton, OR, and WaNPRC, Seattle, WA), and the Integrated Research
Facility (IRF) on the Rocky Mountain Laboratories (RML) campus, Hamilton, MT. Nonhuman primates are
unique, long-lived species that share many physiologic similarities with humans. These similarities include
body composition, maturation, reproduction, metabolism and close genetic relatedness. Of NHPs available
for research, Old World monkey species have the closest evolutionary relationship to humans and they are
essential surrogates for biomedical research focused on major human diseases that lack suitable
alternative animal models. The organization and function of the NHP immune system closely resembles
that of humans and their contribution to understanding the complex interrelationships of the different
components of the immune system in the defense against infectious agents is particularly notable.
Nonhuman primates have long been recognized for their value as comparative models for human vaccine
development, efficacy testing and safety evaluation, and for the investigation of fundamental questions in
basic immunology. Many of these models have demonstrated merit for pathogenesis research and vaccine
development to contain emerging and re-emerging infectious diseases, H5N1 and 1918 influenza (1-3),
Ebola and Marburg viruses (4), monkey pox virus (5, 6), West Nile virus (7, 8), Junin virus (9), yellow fever
virus and Dengue fever virus (10, 11). Their research value notwithstanding, NHPs are complex, higher
order species that require specialized expertise, infrastructure and staff in a research setting.
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会议论文
Core B: Non-Human Primate Core
-
批准号:10723637
-
项目类别:
-
资助金额:$43.77万
-
财政年份:2023
-
负责人:Michael K Axthelm
-
依托单位:
Non Human Primate Core
-
批准号:10709006
-
项目类别:
-
资助金额:$161.02万
-
财政年份:2022
-
负责人:Michael K Axthelm
-
依托单位:
Non Human Primate Core
-
批准号:10619299
-
项目类别:
-
资助金额:$148.9万
-
财政年份:2022
-
负责人:Michael K Axthelm
-
依托单位:
Expanded SPF Rhesus Macaque Breeding Colony for AIDS Research
-
批准号:10457474
-
项目类别:
-
资助金额:$171.44万
-
财政年份:2016
-
负责人:Michael K Axthelm
-
依托单位:
Expanded SPF Rhesus Macaque Breeding Colony for AIDS Research
-
批准号:9765428
-
项目类别:
-
资助金额:$163.28万
-
财政年份:2016
-
负责人:Michael K Axthelm
-
依托单位:
Expanded SPF Rhesus Macaque Breeding Colony for AIDS Research
-
批准号:9536982
-
项目类别:
-
资助金额:$37.18万
-
财政年份:2016
-
负责人:Michael K Axthelm
-
依托单位:
Expanded SPF Rhesus Macaque Breeding Colony for AIDS Research
-
批准号:10014300
-
项目类别:
-
资助金额:$171.44万
-
财政年份:2016
-
负责人:Michael K Axthelm
-
依托单位:
Expanded SPF Rhesus Macaque Breeding Colony for AIDS Research
-
批准号:9204170
-
项目类别:
-
资助金额:$127.97万
-
财政年份:2016
-
负责人:Michael K Axthelm
-
依托单位:
Phase 2 Enhancement of Outdoor Group Housing for U42 SPF 9 Rhesus Macaques
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批准号:10360780
-
项目类别:
-
资助金额:$50.0万
-
财政年份:2016
-
负责人:Michael K Axthelm
-
依托单位:
Expanded SPF Rhesus Macaque Breeding Colony for AIDS Research
-
批准号:10338457
-
项目类别:
-
资助金额:$171.44万
-
财政年份:2016
-
负责人:Michael K Axthelm
-
依托单位:
Novel Caging and Equipment to Enhance Social Interaction and Animal Wellbeing in U42 SPF9 Rhesus Macaques.
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批准号:10404873
-
项目类别:
-
资助金额:$49.98万
-
财政年份:2016
-
负责人:Michael K Axthelm
-
依托单位:
Nonhuman Primate Core
-
批准号:8234055
-
项目类别:
-
资助金额:$55.69万
-
财政年份:2011
-
负责人:Michael K Axthelm
-
依托单位:
ESTABLISHMENT OF SPECIFIC PATHOGEN FREE RHESUS AND PIGTAIL MACAQUE COLONIES
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批准号:8357744
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项目类别:
-
资助金额:$24.36万
-
财政年份:2011
-
负责人:Michael K Axthelm
-
依托单位:
ESTABLISHMENT OF SPECIFIC PATHOGEN FREE RHESUS AND PIGTA: AIDS GENOME
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批准号:8359540
-
项目类别:
-
资助金额:$12.71万
-
财政年份:2011
-
负责人:Michael K Axthelm
-
依托单位:
ESTABLISHMENT OF SPECIFIC PATHOGEN FREE RHESUS AND PIGTA: AIDS THERAP AGENTS
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批准号:8359543
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项目类别:
-
资助金额:$12.71万
-
财政年份:2011
-
负责人:Michael K Axthelm
-
依托单位:
IMMUNIZATION OF ORAL MUCOSA FOR INDUCTION OF RECTAL AND GENITAL MOCOSAL IMMUNITY
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批准号:8357793
-
项目类别:
-
资助金额:$19.49万
-
财政年份:2011
-
负责人:Michael K Axthelm
-
依托单位:
Nonhuman Primate
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批准号:8198159
-
项目类别:
-
资助金额:$213.88万
-
财政年份:2011
-
负责人:Michael K Axthelm
-
依托单位:
Nonhuman Primate
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批准号:8117934
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项目类别:
-
资助金额:$84.72万
-
财政年份:2011
-
负责人:Michael K Axthelm
-
依托单位:
ESTABLISHMENT OF SPECIFIC PATHOGEN FREE RHESUS MACAQUE COLONIES
-
批准号:8357878
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项目类别:
-
资助金额:$24.36万
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财政年份:2011
-
负责人:Michael K Axthelm
-
依托单位:
PACIFIC NW REGIONAL CENTER OF EXCELLENCE NHP CORE YELLOW FEVER
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批准号:8357832
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项目类别:
-
资助金额:$7.28万
-
财政年份:2011
-
负责人:Michael K Axthelm
-
依托单位:
海外基金