Nonhuman Primate Core

非人类灵长类动物（NHP）核心是一个多中心的核心结构，以提供太平洋西北部 区域卓越中心（PNWRCE），拥有专门饲养动物的资源和独特的设施 以及传染病研究的专业调查和技术专长， 使用NHP。The Core的表演场地包括俄勒冈州和华盛顿国家灵长类动物园 研究中心（ONPRC比弗顿，OR和WaNPRC，西雅图，WA）和综合研究中心 位于落基山实验室（RML）园区（汉密尔顿，MT）的IRF设施。非人类灵长类动物 它们是独特的长寿物种，与人类有许多生理相似之处。这些相似之处包括 身体组成、成熟、繁殖、代谢和密切的遗传关系。现有的国家卫生方案 在研究中，旧大陆的猴子物种与人类有着最密切的进化关系， 生物医学研究的基本替代品，重点是缺乏适当的人类疾病， 替代动物模型。NHP免疫系统的组织和功能与 人类及其对理解不同文明之间复杂的相互关系的贡献 免疫系统的组成部分在防御传染性病原体中的作用尤其显著。 长期以来，非人灵长类动物被认为是人类疫苗的比较模型 开发、功效测试和安全性评价，以及研究 基础免疫学这些模型中的许多已被证明是致病机制研究和疫苗的价值 发展以遏制新出现和重新出现的传染病，H5 N1和1918年流感（1-3）， 埃博拉和马尔堡病毒（4）、猴痘病毒（5、6）、西尼罗河病毒（7、8）、朱宁病毒（9）、黄热病 病毒和登革热病毒（10，11）。尽管它们具有研究价值，但NHP是复杂的， 在研究环境中，需要专门知识、基础设施和工作人员的物种。

The Nonhuman Primate (NHP) Core is a multicenter Core structured to provide the Pacific Northwest Regional Center of Excellence (PNWRCE) with resources for purpose-bred animals and unique facilities and specialized investigative and technical expertise for infectious disease research that is best conducted using NHPs. The Core's performance sites include the Oregon and Washington National Primate Research Centers (ONPRC Beaverton, OR, and WaNPRC, Seattle, WA), and the Integrated Research Facility (IRF) on the Rocky Mountain Laboratories (RML) campus, Hamilton, MT. Nonhuman primates are unique, long-lived species that share many physiologic similarities with humans. These similarities include body composition, maturation, reproduction, metabolism and close genetic relatedness. Of NHPs available for research, Old World monkey species have the closest evolutionary relationship to humans and they are essential surrogates for biomedical research focused on major human diseases that lack suitable alternative animal models. The organization and function of the NHP immune system closely resembles that of humans and their contribution to understanding the complex interrelationships of the different components of the immune system in the defense against infectious agents is particularly notable. Nonhuman primates have long been recognized for their value as comparative models for human vaccine development, efficacy testing and safety evaluation, and for the investigation of fundamental questions in basic immunology. Many of these models have demonstrated merit for pathogenesis research and vaccine development to contain emerging and re-emerging infectious diseases, H5N1 and 1918 influenza (1-3), Ebola and Marburg viruses (4), monkey pox virus (5, 6), West Nile virus (7, 8), Junin virus (9), yellow fever virus and Dengue fever virus (10, 11). Their research value notwithstanding, NHPs are complex, higher order species that require specialized expertise, infrastructure and staff in a research setting.