Nonhuman Primate Core

非人灵长类(NHP)核心是一个多中心核心，旨在为太平洋西北地区提供 区域卓越中心(PNWRCE)，拥有专门饲养动物的资源和独特的设施 以及传染病研究的专门调查和技术专长，最好是进行 使用NHP。核心表演网站包括俄勒冈州和华盛顿国家灵长类动物 研究中心(ONPRC比弗顿，或，和WaNPRC，西雅图，华盛顿州)，和综合研究 位于密苏里州汉密尔顿落基山实验室(RML)园区的IRF。非人灵长类动物 独特的、长寿的物种，在生理上与人类有许多相似之处。这些相似之处包括 身体成分、成熟、繁殖、新陈代谢和密切的遗传关系。可用NHP的 在研究方面，东半球猴子物种与人类有着最密切的进化关系，它们是 生物医学研究的基本替代品专注于缺乏合适的 另类动物模型。NHP免疫系统的组织和功能与 以及人类对理解不同物种之间复杂的相互关系的贡献 免疫系统的组成部分在防御感染性病原体方面尤为显著。 长期以来，非人灵长类动物被认为是人类疫苗的比较模型。 开发、药效测试和安全性评估，以及调查 基础免疫学。这些模型中有许多已经证明了在发病机制研究和疫苗方面的优点。 发展以遏制新出现和再次出现的传染病、H5N1和1918年流感(1-3)； 埃博拉和马尔堡病毒(4)，猴痘病毒(5，6)，西尼罗河病毒(7，8)，朱宁病毒(9)，黄热病 病毒和登革热病毒(10，11)。尽管它们具有研究价值，但NHP是复杂的、更高的 订购在研究环境中需要专业知识、基础设施和工作人员的物种。

The Nonhuman Primate (NHP) Core is a multicenter Core structured to provide the Pacific Northwest Regional Center of Excellence (PNWRCE) with resources for purpose-bred animals and unique facilities and specialized investigative and technical expertise for infectious disease research that is best conducted using NHPs. The Core's performance sites include the Oregon and Washington National Primate Research Centers (ONPRC Beaverton, OR, and WaNPRC, Seattle, WA), and the Integrated Research Facility (IRF) on the Rocky Mountain Laboratories (RML) campus, Hamilton, MT. Nonhuman primates are unique, long-lived species that share many physiologic similarities with humans. These similarities include body composition, maturation, reproduction, metabolism and close genetic relatedness. Of NHPs available for research, Old World monkey species have the closest evolutionary relationship to humans and they are essential surrogates for biomedical research focused on major human diseases that lack suitable alternative animal models. The organization and function of the NHP immune system closely resembles that of humans and their contribution to understanding the complex interrelationships of the different components of the immune system in the defense against infectious agents is particularly notable. Nonhuman primates have long been recognized for their value as comparative models for human vaccine development, efficacy testing and safety evaluation, and for the investigation of fundamental questions in basic immunology. Many of these models have demonstrated merit for pathogenesis research and vaccine development to contain emerging and re-emerging infectious diseases, H5N1 and 1918 influenza (1-3), Ebola and Marburg viruses (4), monkey pox virus (5, 6), West Nile virus (7, 8), Junin virus (9), yellow fever virus and Dengue fever virus (10, 11). Their research value notwithstanding, NHPs are complex, higher order species that require specialized expertise, infrastructure and staff in a research setting.