Expanded SPF Rhesus Macaque Breeding Colony for AIDS Research

扩大 SPF 恒河猴繁殖群以进行艾滋病研究

基本信息

  • 批准号:
    10338457
  • 负责人:
  • 金额:
    $ 171.44万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-08-01 至 2024-07-31
  • 项目状态:
    已结题

项目摘要

Project Summary, Overall “Expanded SPF Rhesus Macaque Breeding Colony for AIDS Research” The Indian rhesus macaque (Macaca mulatta) develops a disease that closely mimics human acquired immunodeficiency syndrome (AIDS) when infected by simian immunodeficiency virus (SIV) or chimeric simian-human immunodeficiency viruses (SHIV), and represents the best animal model for HIV infection. Preclinical vaccine development is heavily dependent on the SIV and SHIV rhesus macaque models. The value and utility of the model are markedly enhanced by improving the level of microbial and genetic characterization. Macaques free of ubiquitous viruses that are homologues of human viruses responsible for opportunistic infections are essential for a growing number of AIDS-related opportunistic infection models and for viral vaccine vector development based on these agents. The utility of macaque models for immunological research has been hindered by the unprecedented complexity of their major histocompatibility complexes. Comprehensive MHC genotyping has the potential to revolutionize the use of macaques in infectious disease research and to guide functional immunology studies. MHC-restricted cellular immune responses are crucial in protective immunity and resistance to infectious diseases. The comprehensive objective of this application is to increase the capacity of the ONPRC AIDS Research Expanded SPF Breeding Colony to provide genetically characterized Indian-origin rhesus macaques free of a broad number of enzootic and zoonotic agents to enhance the usefulness of the resource for cutting edge opportunistic agent and vaccine research.
项目总结,总体

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Michael K Axthelm其他文献

Michael K Axthelm的其他文献

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{{ truncateString('Michael K Axthelm', 18)}}的其他基金

Core B: Non-Human Primate Core
核心 B:非人类灵长类核心
  • 批准号:
    10723637
  • 财政年份:
    2023
  • 资助金额:
    $ 171.44万
  • 项目类别:
Non Human Primate Core
非人类灵长类核心
  • 批准号:
    10709006
  • 财政年份:
    2022
  • 资助金额:
    $ 171.44万
  • 项目类别:
Non Human Primate Core
非人类灵长类核心
  • 批准号:
    10619299
  • 财政年份:
    2022
  • 资助金额:
    $ 171.44万
  • 项目类别:
Expanded SPF Rhesus Macaque Breeding Colony for AIDS Research
扩大 SPF 恒河猴繁殖群以进行艾滋病研究
  • 批准号:
    10457474
  • 财政年份:
    2016
  • 资助金额:
    $ 171.44万
  • 项目类别:
Expanded SPF Rhesus Macaque Breeding Colony for AIDS Research
扩大 SPF 恒河猴繁殖群以进行艾滋病研究
  • 批准号:
    9765428
  • 财政年份:
    2016
  • 资助金额:
    $ 171.44万
  • 项目类别:
Expanded SPF Rhesus Macaque Breeding Colony for AIDS Research
扩大 SPF 恒河猴繁殖群以进行艾滋病研究
  • 批准号:
    9536982
  • 财政年份:
    2016
  • 资助金额:
    $ 171.44万
  • 项目类别:
Expanded SPF Rhesus Macaque Breeding Colony for AIDS Research
扩大 SPF 恒河猴繁殖群以进行艾滋病研究
  • 批准号:
    10014300
  • 财政年份:
    2016
  • 资助金额:
    $ 171.44万
  • 项目类别:
Expanded SPF Rhesus Macaque Breeding Colony for AIDS Research
扩大 SPF 恒河猴繁殖群以进行艾滋病研究
  • 批准号:
    9204170
  • 财政年份:
    2016
  • 资助金额:
    $ 171.44万
  • 项目类别:
Phase 2 Enhancement of Outdoor Group Housing for U42 SPF 9 Rhesus Macaques
U42 SPF 9 恒河猴户外群舍第二期强化工程
  • 批准号:
    10360780
  • 财政年份:
    2016
  • 资助金额:
    $ 171.44万
  • 项目类别:
Novel Caging and Equipment to Enhance Social Interaction and Animal Wellbeing in U42 SPF9 Rhesus Macaques.
新型笼具和设备可增强 U42 SPF9 恒河猴的社交互动和动物福祉。
  • 批准号:
    10404873
  • 财政年份:
    2016
  • 资助金额:
    $ 171.44万
  • 项目类别:

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  • 财政年份:
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  • 财政年份:
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