PACIFIC NW REGIONAL CENTER OF EXCELLENCE NHP CORE YELLOW FEVER

西北太平洋区域卓越中心 NHP 核心黄热病

• 批准号: 8357832
• 负责人: Michael K Axthelm
• 金额: $ 7.28万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357832
• 关键词: CD8B1 gene; Chikungunya virus; Complex; Development; Ebola Vaccines; Ebola virus; Emerging Communicable Diseases; Funding; Grant; Immune; Immunity; Infectious Diseases Research; Laboratories; Modeling; Monkeypox; National Center for Research Resources; National Institute of Allergy and Infectious Disease; Oregon; Pacific Northwest; Primates; Principal Investigator; Public Health; Research; Research Activity; Research Infrastructure; Research Personnel; Resources; Risk; Source; Structure; T cell response; Technical Expertise; Testing; United States National Institutes of Health; Vaccines; Virus; Virus Diseases; Washington; Yellow Fever; Yellow fever virus; aged; animal breeding; biothreat; cost; immunogenicity; infrastructure development; interest; killings; nonhuman primate; performance site; prevent; prototype; research facility; vaccine efficacy; vaccine evaluation; vector vaccine

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Pacific Northwest Regional Center of Excellence (PNWRCE) Nonhuman Primate Core is a multicenter Core structured to provide resources for purpose-bred animals and unique facilities and specialized investigative and technical expertise for infectious disease research of interest to the National Institutes of Health's National Institute of Allergy and Infectious Diseases (NIAID) that are best conducted in nonhuman primates. The global objective of the Core is to provide the necessary expertise and specialized infrastructure for development and safe use of complex nonhuman primate models of potential bio-threats and emerging infectious disease that endanger public health. The core supports the nonhuman primate infectious disease research objectives of the PNWRCE as well as those of collaborating investigators within Region X from performance sites at the Oregon and Washington National Primate Research Centers (ONPRC Beaverton, OR, and WaNPRC, Seattle, WA), and the Integrated Research Facility (IRF) on the Rocky Mountain Laboratories (RML) campus, Hamilton, MT. Research activities currently supported by the core include use of a yellow fever virus challenge model for in-depth testing of the immunogenicity, durability of immunity and efficacy of a prototype killed yellow fever virus vaccine in normal and at-risk subjects; use of an Ebola virus challenge model to conduct immunogenicity studies with replication competent and defective vaccine vectors, determine immune correlates of protection conferred by an efficacious Ebola vaccine and test vaccine efficacy in vulnerable (young and old) subjects; development of a challenge model for testing vaccine strategies to prevent Chikungunya virus infection; and use of a monkey pox challenge model to test strategies aimed at bolstering virus-specific CD8 T cell responses in aged subjects.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 太平洋西北区域卓越中心 (PNWRCE) 非人类灵长类核心是一个多中心核心，旨在为美国国立卫生研究院国家过敏和传染病研究所 (NIAID) 感兴趣的传染病研究提供专门饲养的动物资源和独特的设施以及专门的调查和技术专长，这些研究最好在非人类灵长类动物中进行。 该核心的全球目标是提供必要的专业知识和专门基础设施，以开发和安全使用复杂的非人类灵长类动物模型，以应对危害公共健康的潜在生物威胁和新出现的传染病。该核心支持 PNWRCE 的非人类灵长类传染病研究目标，以及俄勒冈州和华盛顿国家灵长类研究中心（俄勒冈州 ONPRC 比弗顿和华盛顿州西雅图 WaNPRC）以及蒙大拿州汉密尔顿落基山实验室 (RML) 园区综合研究设施 (IRF) 的 X 区合作研究人员的目标。目前核心支持的研究活动包括使用黄热病病毒攻击模型，深入测试灭活黄热病病毒疫苗原型在正常和高危受试者中的免疫原性、免疫持久性和功效；使用埃博拉病毒攻击模型对具有复制能力和有缺陷的疫苗载体进行免疫原性研究，确定有效的埃博拉疫苗所赋予的保护的免疫相关性，并测试疫苗在脆弱（年轻和年老）受试者中的功效；开发挑战模型来测试预防基孔肯雅病毒感染的疫苗策略；并使用猴痘攻击模型来测试旨在增强老年受试者中病毒特异性 CD8 T 细胞反应的策略。