A New Population-scale Approach for the Study of Psychological Stress in the Transition to Adulthood
研究成年过渡过程中心理压力的新人口规模方法
基本信息
- 批准号:10369850
- 负责人:
- 金额:$ 23.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-30 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAgeArchivesBiological MarkersBrainCOVID-19ChildChronic stressCollectionCommunitiesConsumptionContraceptive UsageCourtshipDNADataDemographic TransitionsDiagnosticDocumentationEvaluationEventExposure toFailureFamilyFamily StudyGeneral PopulationHairHealthHourHouseholdHumanHydrocortisoneIndividualInterventionInvestigationLaboratoriesLinkMarriageMeasurementMeasuresMental HealthNeighborhoodsOutcomeOutcome MeasureParentsParticipantPatient Self-ReportPhysiologicalPopulationPopulation ResearchPopulation StudyPredispositionProceduresProcessProductionProtocols documentationPsychological StressRandomizedRefusal to ParticipateReportingResearchResearch PersonnelResourcesRespondentRiskRisk FactorsRisk-TakingRoleSalivaSamplingScienceSelection BiasSelf-ExaminationShapesStressSurveysTelephoneTestingTimeVisitagedarmbasechild bearingcognitive performancecohortcostdesignexperienceexperimental studyfield studyimprovedinnovationmembernovel strategiesresilienceresponsesample collectionsubstance usesuccesstherapy designyoung adult
项目摘要
PROJECT SUMMARY
Population-scale measurements of psychological stress during the transition to adulthood are generally con-
strained to either self-reported measures or biomarkers that reflect only recent hours of brain response to
stress. Recent breakthroughs in the use of hair to obtain stable measures of cortisol—a biomarker for the im-
pact of stress on the human brain—has the potential to revolutionize this science. Hair-based cortisol provides
a reliable measure of brain-experienced stress levels for the three months directly preceding collection of a hair
sample. Laboratory processes for cortisol analysis of hair are now available at a scale that can be used for
general population research. Like some other biomarkers, hair could be collected by study participants them-
selves, greatly lowering the costs of adding such measurement to population-scale research. However, the
field currently has no carefully studied protocol for large-scale hair collection, and no information about the se-
lection biases likely to result from self-collection rather than professional-collection.
We will overcome this obstacle by using a large, randomized experiment to assess options for integration
of hair-based cortisol measurement into population-scale studies. This experiment, comparing self-collection of
hair for cortisol to professional-collection, will be integrated into a long-term family panel study with existing
predictors of stress and the transition to adulthood from neighborhoods, households, parents, and individual
young adults. These measures will support comprehensive evaluation of the selection bias in self-collection of
hair samples. We will randomly assign 1,448 respondents aged 18-21 to two arms of an experiment comparing
self-collection of hair to professional-collection. Analyses will examine success collecting hair, the quality of the
hair sample, and the participant’s self-evaluation of the process. We will link measures of these outcomes to
thousands of existing measures of events over time in the individuals’ own lives, their parents’ lives, the lives of
other household members, and the local community context. Analyses will feature exploration of all measures
to identify any that are associated with refusal to participate, compliance with self-collection, quality of the hair
samples, or self-reports of adverse responses to the hair-collection protocols.
Results from these analyses will provide the means to establish the limitations of large-scale hair-based
cortisol self-collection. We will design an optimal protocol for integrating hair-based cortisol collection into pop-
ulation studies across settings and release that protocol to the public. We will also archive these innovative
cortisol measures and collection procedures at ICPSR, allowing all researchers to launch innovative new anal-
yses of psychological stress in the transition to adulthood. At the conclusion of this R21, our team will propose
R01-scale research using this new protocol to link mental health before COVID-19 and stress during COVID-
19-era transitions to adulthood to trajectories of courtship, marriage, contraceptive use, and childbearing.
项目摘要
在向成年过渡期间对心理压力的人口规模测量通常是一致的,
紧张的自我报告的措施或生物标志物,只反映最近几个小时的大脑反应,
应力最近的突破,在使用头发,以获得稳定的措施皮质醇-生物标志物的im-
压力对人类大脑的影响-有可能彻底改变这门科学。毛发中的皮质醇
一个可靠的测量大脑经历的压力水平的三个月前直接收集头发
sample.现在,用于头发皮质醇分析的实验室过程可用于以下规模:
一般人口研究。像其他一些生物标志物一样,研究参与者可以收集头发-
这大大降低了在人口规模研究中增加这种测量的成本。但
菲尔德目前还没有仔细研究过大规模毛发收集的协议,也没有关于SE的信息,
选择偏见可能是由于自我收集而不是专业收集。
我们将通过一个大规模的随机实验来评估整合的选择,
将基于毛发的皮质醇测量纳入人群规模的研究。本实验比较了
头发的皮质醇,以专业的收集,将纳入一个长期的家庭小组研究与现有的
压力的预测因素和从社区,家庭,父母和个人向成年的过渡
年轻人这些措施将支持对自我收集中的选择偏差进行全面评估
头发样本我们将1,448名年龄在18-21岁之间的受访者随机分配到两组实验中,
自我收集的头发,以专业收集。分析将检查成功收集头发,质量的
头发样本,以及参与者对过程的自我评价。我们将把这些结果的衡量标准与
成千上万的现有措施的事件随着时间的推移,在个人的生活,他们的父母的生活,
其他家庭成员和当地社区背景。分析将探索所有措施
以确定任何与拒绝参与,遵守自我收集,头发质量
样本,或对毛发收集方案的不良反应的自我报告。
这些分析的结果将提供建立大规模基于毛发的
皮质醇自我收集。我们将设计一个最佳的协议,将头发为基础的皮质醇收集到流行,
跨环境的评估研究,并向公众发布该协议。我们还将把这些创新的
皮质醇的措施和收集程序在ICPSR,使所有的研究人员推出创新的新的分析,
在向成年过渡过程中的心理压力。在R21结束时,我们的团队将提出
R 01规模的研究,使用这种新的协议,以联系心理健康之前的COVID-19和压力期间的COVID-19-
19-时代过渡到成年期的求爱,婚姻,避孕药具的使用和生育的轨迹。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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William G. Axinn其他文献
Pandemic changes in U.S. contraceptive use: National survey estimates reveal significant differences by demographic subgroups
美国避孕使用情况的大流行变化:全国调查估计显示不同人口亚群之间存在显著差异
- DOI:
10.1016/j.contraception.2024.110723 - 发表时间:
2025-02-01 - 期刊:
- 影响因子:2.300
- 作者:
William G. Axinn;Brady T. West;Heather M. Schroeder;Laura D. Lindberg - 通讯作者:
Laura D. Lindberg
William G. Axinn的其他文献
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{{ truncateString('William G. Axinn', 18)}}的其他基金
A New Population-scale Approach for the Study of Psychological Stress in the Transition to Adulthood
研究成年过渡过程中心理压力的新人口规模方法
- 批准号:
10493385 - 财政年份:2021
- 资助金额:
$ 23.4万 - 项目类别:
Intergenerational Influences on Marriage, Contraception and Childbearing
婚姻、避孕和生育的代际影响
- 批准号:
10183278 - 财政年份:2020
- 资助金额:
$ 23.4万 - 项目类别:
Interdisciplinary Research Training Program for International Population Science
国际人口科学跨学科研究培训项目
- 批准号:
10186785 - 财政年份:2020
- 资助金额:
$ 23.4万 - 项目类别:
Interdisciplinary Research Training Program for International Population Science
国际人口科学跨学科研究培训项目
- 批准号:
10612801 - 财政年份:2020
- 资助金额:
$ 23.4万 - 项目类别:
Intergenerational Influences on Marriage, Contraception and Childbearing
婚姻、避孕和生育的代际影响
- 批准号:
10604345 - 财政年份:2020
- 资助金额:
$ 23.4万 - 项目类别:
Interdisciplinary Research Training Program for International Population Science
国际人口科学跨学科研究培训项目
- 批准号:
10400067 - 财政年份:2020
- 资助金额:
$ 23.4万 - 项目类别:
Intergenerational Influences on Marriage, Contraception and Childbearing
婚姻、避孕和生育的代际影响
- 批准号:
10366002 - 财政年份:2020
- 资助金额:
$ 23.4万 - 项目类别:
Archiving and Documenting Child Health and Human Development Data Sets
归档和记录儿童健康和人类发展数据集
- 批准号:
9543523 - 财政年份:2017
- 资助金额:
$ 23.4万 - 项目类别:
Reciprocal Relations between Population and Environment
人口与环境的相互关系
- 批准号:
7900948 - 财政年份:2009
- 资助金额:
$ 23.4万 - 项目类别:
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