A New Population-scale Approach for the Study of Psychological Stress in the Transition to Adulthood

研究成年过渡过程中心理压力的新人口规模方法

基本信息

  • 批准号:
    10369850
  • 负责人:
  • 金额:
    $ 23.4万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-09-30 至 2023-08-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY Population-scale measurements of psychological stress during the transition to adulthood are generally con- strained to either self-reported measures or biomarkers that reflect only recent hours of brain response to stress. Recent breakthroughs in the use of hair to obtain stable measures of cortisol—a biomarker for the im- pact of stress on the human brain—has the potential to revolutionize this science. Hair-based cortisol provides a reliable measure of brain-experienced stress levels for the three months directly preceding collection of a hair sample. Laboratory processes for cortisol analysis of hair are now available at a scale that can be used for general population research. Like some other biomarkers, hair could be collected by study participants them- selves, greatly lowering the costs of adding such measurement to population-scale research. However, the field currently has no carefully studied protocol for large-scale hair collection, and no information about the se- lection biases likely to result from self-collection rather than professional-collection. We will overcome this obstacle by using a large, randomized experiment to assess options for integration of hair-based cortisol measurement into population-scale studies. This experiment, comparing self-collection of hair for cortisol to professional-collection, will be integrated into a long-term family panel study with existing predictors of stress and the transition to adulthood from neighborhoods, households, parents, and individual young adults. These measures will support comprehensive evaluation of the selection bias in self-collection of hair samples. We will randomly assign 1,448 respondents aged 18-21 to two arms of an experiment comparing self-collection of hair to professional-collection. Analyses will examine success collecting hair, the quality of the hair sample, and the participant’s self-evaluation of the process. We will link measures of these outcomes to thousands of existing measures of events over time in the individuals’ own lives, their parents’ lives, the lives of other household members, and the local community context. Analyses will feature exploration of all measures to identify any that are associated with refusal to participate, compliance with self-collection, quality of the hair samples, or self-reports of adverse responses to the hair-collection protocols. Results from these analyses will provide the means to establish the limitations of large-scale hair-based cortisol self-collection. We will design an optimal protocol for integrating hair-based cortisol collection into pop- ulation studies across settings and release that protocol to the public. We will also archive these innovative cortisol measures and collection procedures at ICPSR, allowing all researchers to launch innovative new anal- yses of psychological stress in the transition to adulthood. At the conclusion of this R21, our team will propose R01-scale research using this new protocol to link mental health before COVID-19 and stress during COVID- 19-era transitions to adulthood to trajectories of courtship, marriage, contraceptive use, and childbearing.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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William G. Axinn其他文献

Pandemic changes in U.S. contraceptive use: National survey estimates reveal significant differences by demographic subgroups
美国避孕使用情况的大流行变化:全国调查估计显示不同人口亚群之间存在显著差异
  • DOI:
    10.1016/j.contraception.2024.110723
  • 发表时间:
    2025-02-01
  • 期刊:
  • 影响因子:
    2.300
  • 作者:
    William G. Axinn;Brady T. West;Heather M. Schroeder;Laura D. Lindberg
  • 通讯作者:
    Laura D. Lindberg

William G. Axinn的其他文献

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{{ truncateString('William G. Axinn', 18)}}的其他基金

A New Population-scale Approach for the Study of Psychological Stress in the Transition to Adulthood
研究成年过渡过程中心理压力的新人口规模方法
  • 批准号:
    10493385
  • 财政年份:
    2021
  • 资助金额:
    $ 23.4万
  • 项目类别:
Intergenerational Influences on Marriage, Contraception and Childbearing
婚姻、避孕和生育的代际影响
  • 批准号:
    10183278
  • 财政年份:
    2020
  • 资助金额:
    $ 23.4万
  • 项目类别:
Interdisciplinary Research Training Program for International Population Science
国际人口科学跨学科研究培训项目
  • 批准号:
    10186785
  • 财政年份:
    2020
  • 资助金额:
    $ 23.4万
  • 项目类别:
Interdisciplinary Research Training Program for International Population Science
国际人口科学跨学科研究培训项目
  • 批准号:
    10612801
  • 财政年份:
    2020
  • 资助金额:
    $ 23.4万
  • 项目类别:
Intergenerational Influences on Marriage, Contraception and Childbearing
婚姻、避孕和生育的代际影响
  • 批准号:
    10604345
  • 财政年份:
    2020
  • 资助金额:
    $ 23.4万
  • 项目类别:
Interdisciplinary Research Training Program for International Population Science
国际人口科学跨学科研究培训项目
  • 批准号:
    10400067
  • 财政年份:
    2020
  • 资助金额:
    $ 23.4万
  • 项目类别:
Intergenerational Influences on Marriage, Contraception and Childbearing
婚姻、避孕和生育的代际影响
  • 批准号:
    10366002
  • 财政年份:
    2020
  • 资助金额:
    $ 23.4万
  • 项目类别:
Archiving and Documenting Child Health and Human Development Data Sets
归档和记录儿童健康和人类发展数据集
  • 批准号:
    9543523
  • 财政年份:
    2017
  • 资助金额:
    $ 23.4万
  • 项目类别:
Genes, Environment, Family and Mental Health
基因、环境、家庭和心理健康
  • 批准号:
    9127827
  • 财政年份:
    2015
  • 资助金额:
    $ 23.4万
  • 项目类别:
Reciprocal Relations between Population and Environment
人口与环境的相互关系
  • 批准号:
    7900948
  • 财政年份:
    2009
  • 资助金额:
    $ 23.4万
  • 项目类别:

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