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A New Population-scale Approach for the Study of Psychological Stress in the Transition to Adulthood

研究成年过渡过程中心理压力的新人口规模方法

基本信息

批准号：
10369850
负责人：
William G. Axinn
金额：
$ 23.4万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2023-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10369850
关键词：
Address Adult Age Archives Biological Markers Brain COVID-19 Child Chronic stress Collection Communities Consumption Contraceptive Usage Courtship DNA Data Demographic Transitions Diagnostic Documentation Evaluation Event Exposure to Failure Family Family Study General Population Hair Health Hour Household Human Hydrocortisone Individual Intervention Investigation Laboratories Link Marriage Measurement Measures Mental Health Neighborhoods Outcome Outcome Measure Parents Participant Patient Self-Report Physiological Population Population Research Population Study Predisposition Procedures Process Production Protocols documentation Psychological Stress Randomized Refusal to Participate Reporting Research Research Personnel Resources Respondent Risk Risk Factors Risk-Taking Role Saliva Sampling Science Selection Bias Self-Examination Shapes Stress Surveys Telephone Testing Time Visit aged arm base child bearing cognitive performance cohort cost design experience experimental study field study improved innovation member novel strategies resilience response sample collection substance use success therapy design young adult

项目摘要

PROJECT SUMMARY Population-scale measurements of psychological stress during the transition to adulthood are generally con- strained to either self-reported measures or biomarkers that reflect only recent hours of brain response to stress. Recent breakthroughs in the use of hair to obtain stable measures of cortisol—a biomarker for the im- pact of stress on the human brain—has the potential to revolutionize this science. Hair-based cortisol provides a reliable measure of brain-experienced stress levels for the three months directly preceding collection of a hair sample. Laboratory processes for cortisol analysis of hair are now available at a scale that can be used for general population research. Like some other biomarkers, hair could be collected by study participants them- selves, greatly lowering the costs of adding such measurement to population-scale research. However, the field currently has no carefully studied protocol for large-scale hair collection, and no information about the se- lection biases likely to result from self-collection rather than professional-collection. We will overcome this obstacle by using a large, randomized experiment to assess options for integration of hair-based cortisol measurement into population-scale studies. This experiment, comparing self-collection of hair for cortisol to professional-collection, will be integrated into a long-term family panel study with existing predictors of stress and the transition to adulthood from neighborhoods, households, parents, and individual young adults. These measures will support comprehensive evaluation of the selection bias in self-collection of hair samples. We will randomly assign 1,448 respondents aged 18-21 to two arms of an experiment comparing self-collection of hair to professional-collection. Analyses will examine success collecting hair, the quality of the hair sample, and the participant’s self-evaluation of the process. We will link measures of these outcomes to thousands of existing measures of events over time in the individuals’ own lives, their parents’ lives, the lives of other household members, and the local community context. Analyses will feature exploration of all measures to identify any that are associated with refusal to participate, compliance with self-collection, quality of the hair samples, or self-reports of adverse responses to the hair-collection protocols. Results from these analyses will provide the means to establish the limitations of large-scale hair-based cortisol self-collection. We will design an optimal protocol for integrating hair-based cortisol collection into pop- ulation studies across settings and release that protocol to the public. We will also archive these innovative cortisol measures and collection procedures at ICPSR, allowing all researchers to launch innovative new anal- yses of psychological stress in the transition to adulthood. At the conclusion of this R21, our team will propose R01-scale research using this new protocol to link mental health before COVID-19 and stress during COVID- 19-era transitions to adulthood to trajectories of courtship, marriage, contraceptive use, and childbearing.

项目总结