Genes, Environment, Family and Mental Health

基因、环境、家庭和心理健康

• 批准号: 9127827
• 负责人: William G. Axinn
• 金额: $ 29.97万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-11 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9127827
• 关键词: Age of Onset; Asia; Calendar; Communities; Complex; Conflict (Psychology); DNA; Data; Demography; Development; Disease; Documentation; Elderly; Endowment; Environment; Environmental Risk Factor; Epidemiology; Etiology; European; Event; Exposure to; Family; Family Study; Family health status; Funding; Genes; Genetic; Genomics; Genotype; Health; Health Surveys; Household; Individual; International; Learning; Life; Major Depressive Disorder; Measurement; Measures; Mediating; Mental Health; Mental disorders; National Institute of Child Health and Human Development; Nepal; Outcome; Parents; Participant; Phenotype; Policies; Population; Population Group; Post-Traumatic Stress Disorders; Prevalence; Psychopathology; Recording of previous events; Relative (related person); Research; Resources; Risk; Risk Factors; Role; Saliva; Sampling; Services; Shapes; Shipping; Ships; Social Environment; Social support; Source; South Asian; Surveys; Symptoms; Time; Variant; Violence; adverse outcome; alcohol use disorder; arm; base; case control; data sharing; design; disability; experience; gene environment interaction; genetic analysis; genetic risk factor; genome-wide; improved; life history; mental health epidemiology; migration; novel strategies; population based; prospective; psychogenetics; resilience

 DESCRIPTION (provided by applicant): Psychiatric disorders are the leading source of disability worldwide. In addition to the individual suffering they entail, the disability associate with these disorders includes substantial consequences for family and health outcomes. Dissecting the relationship among family, community and psychiatric factors is complex because of the high potential for reciprocal causation among them. The result is a formidable challenge to understanding the role of psychiatric disorders in a wide range of adverse outcomes. The first step toward disentangling this complex relationship is to identify the role of causal factors that precede the formation of psychiatric disorders so that subsequent steps can estimate the mediating power of psychiatric disorders in long-term outcomes, such as family change and variation. Here we propose to take this first step using a transformative new approach with the potential to significantly advance the study of both mental health and family. This project will capitalize on a confluence of unprecedented opportunities to advance our understanding of the formation of psychiatric disorders. We propose to integrate: (1) a long-term community and family panel study with exceptional measurement of social environment (the Chitwan Valley Family Study - CVFS); (2) a setting of unusually high exposures to risk factors (South Asia); and (3) recent advances in psychiatric genetics that have identified polygenic risk profiles contributing to psychiatric disorders. We focus on three psychiatric phenotypes that are common and have the best established relationship to family and social environment: major depressive disorder (MDD), post-traumatic stress disorder (PTSD), and alcohol use disorders (AUD). Our specific aims are: (Aim 1) Create a unique scientific resource by collecting psychiatric phenotypes, demographic information and biospecimens from participants in the CVFS. The CVFS is an existing NICHD- funded study comprising 9,499 individuals from 2,600 households in various sub-population groups; (Aim 2) Conduct demographic/epidemiologic analyses to identify key predictors of psychiatric disorder in a large population-based sample of South Asian families and communities in a controlled-comparison design; (Aim 3) Perform genome wide genotyping and conduct analyses to examine the role of polygenic risk scores and genetic modifiers of environmental risk and resilience factors. The successful completion of these aims will: (1) For the first time, extend both the demography/epidemiology of mental health and psychiatric genetic findings from the European Diaspora to South Asian populations; (2) Establish the role of community change and gene- environment interactions in producing common psychiatric disorders most likely to shape long-term family outcomes; and (3) Create a transformative new resource for the scientific community to harness advances in our understanding of psychiatric disorders to learn the potential of those disorders to shape many different later life personal, family and health outcomes.

 描述（由申请人提供）：精神疾病是全球残疾的主要来源。除了给个人带来痛苦之外，与这些疾病相关的残疾还包括对家庭和健康结果的严重后果。剖析家庭、社区和精神因素之间的关系是复杂的，因为它们之间有很高的相互因果关系。其结果是一个巨大的挑战，以了解精神疾病的作用，在广泛的不良后果。解开这种复杂关系的第一步是确定精神疾病形成之前的因果因素的作用，以便后续步骤可以估计精神疾病在长期结果（例如家庭变化和变异）中的中介作用。在这里，我们建议采取这第一步，使用一种变革性的新方法，有可能显着推进心理健康和家庭的研究。 该项目将利用前所未有的机会，以促进我们对精神疾病形成的理解。我们建议整合：（1）一项长期的社区和家庭小组研究，对社会环境进行了特殊的测量（奇旺谷家庭研究- CVFS）;（2）一个异常高风险因素暴露的环境（南亚）;（3）精神遗传学的最新进展，已经确定了导致精神疾病的多基因风险特征。我们专注于三种常见的精神病表型，它们与家庭和社会环境的关系最为密切：重度抑郁症（MDD），创伤后应激障碍（PTSD）和酒精使用障碍（AUD）。我们的具体目标是：（目标1）通过收集CVFS参与者的精神病表型、人口统计学信息和生物标本，创建独特的科学资源。CVFS是一项现有的NICHD资助的研究，包括来自不同亚人群组的2，600个家庭的9，499名个体;（目的2）进行人口统计学/流行病学分析，以在控制比较设计中，在南亚家庭和社区的大规模人口样本中确定精神障碍的关键预测因素;（目的3）进行全基因组基因分型和分析，以检查多基因风险评分和环境风险和弹性因素的遗传修饰剂的作用。成功实现这些目标将：（1）首次将欧洲散居者的心理健康人口学/流行病学和精神病遗传学研究结果扩大到南亚人口;（2）确定社区变化和基因-环境相互作用在产生最有可能影响长期家庭结果的常见精神疾病方面的作用;以及（3）为科学界创造一个变革性的新资源，以利用我们对精神疾病理解的进步，了解这些疾病塑造许多不同的晚年个人，家庭和健康结果的潜力。