Genes, Environment, Family and Mental Health

基因、环境、家庭和心理健康

• 批准号: 9127827
• 负责人: William G. Axinn
• 金额: $ 29.97万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-11 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9127827
• 关键词: Age of Onset; Asia; Calendar; Communities; Complex; Conflict (Psychology); DNA; Data; Demography; Development; Disease; Documentation; Elderly; Endowment; Environment; Environmental Risk Factor; Epidemiology; Etiology; European; Event; Exposure to; Family; Family Study; Family health status; Funding; Genes; Genetic; Genomics; Genotype; Health; Health Surveys; Household; Individual; International; Learning; Life; Major Depressive Disorder; Measurement; Measures; Mediating; Mental Health; Mental disorders; National Institute of Child Health and Human Development; Nepal; Outcome; Parents; Participant; Phenotype; Policies; Population; Population Group; Post-Traumatic Stress Disorders; Prevalence; Psychopathology; Recording of previous events; Relative (related person); Research; Resources; Risk; Risk Factors; Role; Saliva; Sampling; Services; Shapes; Shipping; Ships; Social Environment; Social support; Source; South Asian; Surveys; Symptoms; Time; Variant; Violence; adverse outcome; alcohol use disorder; arm; base; case control; data sharing; design; disability; experience; gene environment interaction; genetic analysis; genetic risk factor; genome-wide; improved; life history; mental health epidemiology; migration; novel strategies; population based; prospective; psychogenetics; resilience

 DESCRIPTION (provided by applicant): Psychiatric disorders are the leading source of disability worldwide. In addition to the individual suffering they entail, the disability associate with these disorders includes substantial consequences for family and health outcomes. Dissecting the relationship among family, community and psychiatric factors is complex because of the high potential for reciprocal causation among them. The result is a formidable challenge to understanding the role of psychiatric disorders in a wide range of adverse outcomes. The first step toward disentangling this complex relationship is to identify the role of causal factors that precede the formation of psychiatric disorders so that subsequent steps can estimate the mediating power of psychiatric disorders in long-term outcomes, such as family change and variation. Here we propose to take this first step using a transformative new approach with the potential to significantly advance the study of both mental health and family. This project will capitalize on a confluence of unprecedented opportunities to advance our understanding of the formation of psychiatric disorders. We propose to integrate: (1) a long-term community and family panel study with exceptional measurement of social environment (the Chitwan Valley Family Study - CVFS); (2) a setting of unusually high exposures to risk factors (South Asia); and (3) recent advances in psychiatric genetics that have identified polygenic risk profiles contributing to psychiatric disorders. We focus on three psychiatric phenotypes that are common and have the best established relationship to family and social environment: major depressive disorder (MDD), post-traumatic stress disorder (PTSD), and alcohol use disorders (AUD). Our specific aims are: (Aim 1) Create a unique scientific resource by collecting psychiatric phenotypes, demographic information and biospecimens from participants in the CVFS. The CVFS is an existing NICHD- funded study comprising 9,499 individuals from 2,600 households in various sub-population groups; (Aim 2) Conduct demographic/epidemiologic analyses to identify key predictors of psychiatric disorder in a large population-based sample of South Asian families and communities in a controlled-comparison design; (Aim 3) Perform genome wide genotyping and conduct analyses to examine the role of polygenic risk scores and genetic modifiers of environmental risk and resilience factors. The successful completion of these aims will: (1) For the first time, extend both the demography/epidemiology of mental health and psychiatric genetic findings from the European Diaspora to South Asian populations; (2) Establish the role of community change and gene- environment interactions in producing common psychiatric disorders most likely to shape long-term family outcomes; and (3) Create a transformative new resource for the scientific community to harness advances in our understanding of psychiatric disorders to learn the potential of those disorders to shape many different later life personal, family and health outcomes.

 描述（由适用提供）：精神疾病是全球残疾的主要来源。除了他们所带来的个人苦难外，与这些疾病的残疾人伴侣还对家庭和健康成果造成了重大影响。剖析家庭，社区和精神病因素之间的关系是复杂的，因为它们之间存在互惠原因的潜力。结果是在广泛的不良后果中理解精神疾病的作用的巨大挑战。解开这种复杂关系的第一步是确定在精神疾病形成之前的因果因素的作用，以便随后的步骤可以估计长期结局中精神疾病的中介能力，例如家庭变化和变异。在这里，我们建议使用一种变革性的新方法迈出第一步，以显着推进对心理健康和家庭的研究。该项目将利用前所未有的机会融合，以提高我们对精神疾病形成的理解。我们建议整合：（1）一项长期的社区和家庭小组研究，并具有对社会环境的非凡衡量（Chitwan Valley Family研究-CVFS）； （2）对风险因素（南亚）的暴露率异常高的设置； （3）鉴定出导致精神疾病的多基因风险概况的精神遗传学的最新进展。我们专注于三种常见且与家庭和社会环境具有最佳建立关系的精神病学表型：主要抑郁症（MDD），创伤后应激障碍（PTSD）和酒精使用障碍（AUD）。我们的具体目的是：（目标1）通过收集CVF参与者的精神病表型，人口统计信息和生物表演来创建独特的科学资源。 CVFS是一项现有的NICHD资助研究，涵盖了来自各个子人口组中2600个家庭的9,499名个人； （AIM 2）进行人口/流行病学分析，以在受控养育设计中的南亚家庭和社区样本中确定精神疾病的关键预测指标； （目标3）进行广泛的基因组和进行分析，以检查环境风险和弹性因素的多基因风险评分和遗传修饰符的作用。这些目标的成功完成将：（1）首次将心理健康和精神遗传发现的人口/流行病学从欧洲侨民到南亚人口； （2）确定社区变革和基因环境相互作用在产生最有可能塑造长期家庭结果的常见精神疾病中的作用； （3）为科学界创造了一种变革性的新资源，以利用我们对精神疾病的理解，以了解这些疾病的潜力，以塑造许多以后的生活，家庭和健康成果。