Intergenerational Influences on Marriage, Contraception and Childbearing

项目总结 家庭形成过程，包括婚姻、避孕和生育，是最不受影响的过程之一 影响家庭和儿童健康和福祉的重要因素。实质性的、长期的结论是- 父母家庭对子女家庭形成结果的影响是最有文献记载的 社会科学变革的力量。然而，一个强有力的因素被忽视了--父母的心理 健康。精神障碍不仅在世界各地非常普遍，而且父母的精神障碍也是众所周知的 对孩子产生强大的后果，很可能塑造他们以后的家庭形成过程。我们会 通过将父母精神障碍整合到代际模型中来解决研究中的这一重要差距 使用一项长达24年的前瞻性家庭小组研究形成家庭。为了增进对这些属间的了解-- 使用这些新措施，我们的目标是：(1)对父母的作用产生第一次估计 影响子女今后婚姻、避孕和生育的精神障碍；(2)使用 来自母亲、父亲及其子女的基于DNA的多基因风险评分，以评估遗漏的遗传变量 这些代际模型中的偏差；以及(3)创建和评估性风险的新的前瞻性衡量标准- 服用和使用物质的机制可能会将父母的精神障碍与他们孩子的婚姻联系起来，包括 可追溯使用，并生育。 这一结果将带来三个重大进展。一是全国第一次人口普查 父母精神障碍对子女婚姻、避孕、生育的代际影响-- 英。第二个是首次研究了遗传因素对父母心理代际影响的影响。 家庭形成障碍。到目前为止，几乎所有代际影响家庭的人口模型 形成被迫得出结论，未被观察到的遗传相似性可能解释了已观察到的联系。 我们将引入新一代跨代研究--整合遗传倾向的设计。 第三是我们对儿童婚前性行为所起的作用的理解有了很大的进步。 在将父母因素与子女的家庭形成联系起来方面，如这些事件，避孕措施和物质使用 可以调停这段关系。这些步骤将极大地促进我们对属间的理解-- 对婚姻、避孕和生育的动态的影响，所有这些都对 健康和幸福。

PROJECT SUMMARY Family formation processes, including marriage, contraception, and childbearing, are among the most im- portant factors shaping the health and wellbeing of families and children. The substantial, long-term conse- quences of the parental family for children's family formation outcomes are among the most well-documented forces of change in the social sciences. However, a powerful factor has been overlooked—parental mental health. Not only are mental disorders highly prevalent the world over, but parental mental disorders are known to have powerful consequences for children, likely to shape their later-life family formation processes. We will address this important gap in research by integrating parental mental disorders into intergenerational models of family formation using a 24-year, prospective family panel study. To advance knowledge of these intergenera- tional processes using these new measures, we aim to: (1) Generate the first estimates of the role of parental mental disorders in shaping their children's subsequent marriage, contraception, and childbearing; (2) Use DNA-based polygenic risk scores from mothers, fathers, and their children to assess omitted genetic variable bias in these intergenerational models; and (3) Create and evaluate new prospective measures of sexual risk- taking and substance use mechanisms likely to link parental mental disorders to their children's marriage, con- traceptive use, and childbearing. The results will provide three significant advances. One is the first general population investigation of the intergenerational influence of parental mental disorders on children's marriage, contraception, and childbear- ing. A second is the first study of the genetic contribution to the intergenerational influences of parental mental disorders on family formation. To date nearly all population models of intergenerational influences on family formation are forced to conclude that unobserved genetic similarities may account for observed associations. We will introduce a new generation of intergenerational research—designs that integrate genetic propensities. The third is a significant advance in our understanding of the role played by children's premarital sex, sex with- out contraception, and substance use in linking parental factors to children's family formation, as these events could mediate this relationship. These steps will significantly advance our understanding of the intergenera- tional influences on the dynamics of marriage, contraception, and childbearing, all of which are crucial for health and wellbeing.