Intergenerational Influences on Marriage, Contraception and Childbearing

婚姻、避孕和生育的代际影响

• 批准号: 10604345
• 负责人: William G. Axinn
• 金额: $ 61.6万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10604345
• 关键词: Adult; Age; Archives; Behavior; Cellular Phone; Characteristics; Child; Child Mental Disorders; Child Welfare; Childhood; Clinical; Communities; Contraceptive Usage; Contraceptive methods; DNA; Data; Diagnostic; Disease; Divorce; Education; Elderly; Event; Family; Family Study; Fathers; General Population; Generations; Genetic; Genetic Predisposition to Disease; Genetic Research; Genetic study; Health; High Prevalence; Household; Income; Individual; Infrastructure; Internet; Interview; Investigation; Knowledge; Link; Living Arrangement; Marriage; Measurement; Measures; Mediating; Mental Health; Mental disorders; Modeling; Mothers; National Institute of Child Health and Human Development; National Institute of Mental Health; Outcome; Parents; Personal Satisfaction; Persons; Play; Population; Population Growth; Pregnancy; Process; Recording of previous events; Research; Research Design; Risk Taking; Role; Saliva; Sampling; Severities; Sexually Transmitted Diseases; Shapes; Social Sciences; Structure; Surveys; Telephone Interviews; Variant; Work; child bearing; community-level factor; design; early childhood; effective intervention; experience; innovation; intergenerational; parental influence; parental role; polygenic risk score; prospective; sex; sexual risk taking; substance use; tool; unintended pregnancy

PROJECT SUMMARY Family formation processes, including marriage, contraception, and childbearing, are among the most im- portant factors shaping the health and wellbeing of families and children. The substantial, long-term conse- quences of the parental family for children's family formation outcomes are among the most well-documented forces of change in the social sciences. However, a powerful factor has been overlooked—parental mental health. Not only are mental disorders highly prevalent the world over, but parental mental disorders are known to have powerful consequences for children, likely to shape their later-life family formation processes. We will address this important gap in research by integrating parental mental disorders into intergenerational models of family formation using a 24-year, prospective family panel study. To advance knowledge of these intergenera- tional processes using these new measures, we aim to: (1) Generate the first estimates of the role of parental mental disorders in shaping their children's subsequent marriage, contraception, and childbearing; (2) Use DNA-based polygenic risk scores from mothers, fathers, and their children to assess omitted genetic variable bias in these intergenerational models; and (3) Create and evaluate new prospective measures of sexual risk- taking and substance use mechanisms likely to link parental mental disorders to their children's marriage, con- traceptive use, and childbearing. The results will provide three significant advances. One is the first general population investigation of the intergenerational influence of parental mental disorders on children's marriage, contraception, and childbear- ing. A second is the first study of the genetic contribution to the intergenerational influences of parental mental disorders on family formation. To date nearly all population models of intergenerational influences on family formation are forced to conclude that unobserved genetic similarities may account for observed associations. We will introduce a new generation of intergenerational research—designs that integrate genetic propensities. The third is a significant advance in our understanding of the role played by children's premarital sex, sex with- out contraception, and substance use in linking parental factors to children's family formation, as these events could mediate this relationship. These steps will significantly advance our understanding of the intergenera- tional influences on the dynamics of marriage, contraception, and childbearing, all of which are crucial for health and wellbeing.

项目摘要 家庭的形成过程，包括婚姻、避孕和生育，是最不重要的。 影响家庭和儿童健康和福祉的重要因素。长期的，长期的，长期的， 父母家庭对儿童家庭形成结果的影响是最有据可查的 社会科学的变革力量。然而，一个有力的因素却被忽视了--父母的心理 健康精神障碍不仅在全世界非常普遍，而且父母的精神障碍也是众所周知的。 对儿童产生强大的影响，可能会影响他们以后的家庭形成过程。我们将 通过将父母精神障碍纳入代际模型， 使用24年的前瞻性家庭面板研究进行家庭形成。为了增进对这些间属的了解， 使用这些新的措施，我们的目标是：（1）产生父母的作用的第一个估计 （2）在影响子女以后的婚姻、避孕和生育方面存在精神障碍; 来自母亲、父亲及其子女的基于DNA的多基因风险评分，以评估遗漏的遗传变量 这些代际模型中的偏见;（3）创建和评估新的性风险前瞻性措施- 服用和物质使用机制可能将父母的精神障碍与子女的婚姻联系起来， 以及生育。 研究结果将带来三个重大进展。一个是第一次人口普查， 父母精神障碍对子女婚姻、避孕和生育的代际影响- ing.第二个是第一次研究了遗传对父母心理代际影响的贡献， 家庭形成障碍。迄今为止，几乎所有关于代际对家庭影响的人口模型 研究人员不得不得出结论，未观察到的遗传相似性可能解释了观察到的关联。 我们将介绍新一代的代际研究设计，整合遗传倾向。 第三是我们对儿童婚前性行为所起作用的理解有了重大进展，与- 避孕和物质使用在将父母因素与儿童的家庭形成联系起来时， 可以调解这种关系。这些步骤将大大促进我们对属间- 对婚姻、避孕和生育的动态的影响，所有这些都是至关重要的， 健康和幸福。