Testing the predictive power of neural connectivity: Suicidal ideation in youth exposed to maltreatment
测试神经连接的预测能力:遭受虐待的青少年的自杀意念
基本信息
- 批准号:10373973
- 负责人:
- 金额:$ 17.98万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-04-01 至 2023-03-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdolescentAffectAgeAlgorithmsAmygdaloid structureAwardBehavior assessmentBrainBrain regionCause of DeathChild Abuse and NeglectChildhoodCongressesCouplingDataData CollectionDistalEmotionalEnrollmentExhibitsExposure toFeeling suicidalFunctional Magnetic Resonance ImagingFundingFutureGoalsImpairmentKnowledgeLinkLongitudinal StudiesMatched GroupModelingNational Institute of Mental HealthNegative ValenceParticipantPatient Self-ReportPlayPopulations at RiskPrefrontal CortexProcessPsychophysiologyPublic HealthRecording of previous eventsReportingResearchRestRiskRisk FactorsRisk MarkerRoleSamplingScanningStrategic PlanningSuicideSurgeonTestingUnited States Dept. of Health and Human ServicesValidationVulnerable PopulationsWorkYouthbaseemotion regulationexperiencefollow up assessmentfollow-upfunctional MRI scangraph theoryhigh schoolimprovedinformantinnovationmaltreatmentneural networkneurodevelopmentneuroimagingnovelparent grantpredictive testpreventive interventionprospectiverecruitrelating to nervous systemresponsestatisticssuicidal adolescentsuicidal behaviorsuicidal morbiditysuicidal risksuicide rate
项目摘要
Project Summary/Abstract
In response to national calls from the Surgeon General, Congress, and NIMH, the proposed research will
investigate neural markers of suicidal ideation and behavior in one of the most vulnerable populations at risk
for suicide (i.e., youth with a history of child maltreatment). Child maltreatment is robustly related to youth
suicidal ideation and behavior; yet, child maltreatment alone is a poor predictor of future suicidal ideation and
behavior. Prediction of future suicidal ideation and behavior is critical and may be currently limited by a lack of
knowledge regarding neural underpinnings of known risk factors for suicide. Child maltreatment affects
functioning in brain regions implicated in emotion regulation. Further, emotion regulation may be a key process
underlying suicidal ideation and behavior. The proposed research will prospectively examine network wide
functional connectivity in brain networks implicated in emotion regulation as a predictor of suicidal ideation in
two independent samples of youth with and without histories of child maltreatment. This work will explore
frontolimbic (e.g., dorsolateral prefrontal cortex—amygdala) connectivity during a widely-used emotion
regulation task and resting state scan among youth with and without suicidal ideation and child maltreatment
histories. Further, this work will examine neural connectivity as a prospective predictor of suicidal ideation.
Based on previous research, it is expected that youth with both child maltreatment and suicidal ideation
histories will demonstrate weak frontolimbic connectivity compared to youth with either child maltreatment or
suicidal ideation histories alone and control youth. Further, it is hypothesized that weak frontolimbic
connectivity will prospectively predict suicidal ideation across ~1-2 years across both samples of youth. Here
we have the remarkable ability to cross-validate our findings from one sample in an independent sample of
youth. Using a combination of experimental lab-based paradigms, functional network connectivity, and an
innovative longitudinal, cross-validation of findings, the proposed research offers a substantial advance within
the field that almost exclusively has relied on cross-sectional, single informant, retrospective reports of suicidal
ideation. Participants from two independent samples (total N = 340 youth ages 8-16; data collection supported
by 2 NIMH funded R01s) with a range of child maltreatment and suicidal ideation histories complete a baseline
assessment and fMRI scan, are followed prospectively for ~1-2 years, and complete an additional fMRI scan.
We will combine traditional connectivity analysis (graph theory) and a cutting-edge data-driven algorithm to
cross-validate neural network connectivity findings from baseline and follow-up (~1-2 years). Findings from the
current study may identify concrete markers of risk for suicidal ideation and behavior allowing us to significantly
improve prospective prediction. Advancing knowledge of neural underpinnings of youth suicide is critical for
addressing this significant public health concern. This project directly addresses national calls for action
regarding youth suicide and stands to substantially contribute to the field.
项目总结/摘要
为了响应来自卫生部长、国会和NIMH的全国性呼吁,拟议的研究将
在最脆弱的高危人群中研究自杀意念和行为的神经标志物
对于自杀(即,有虐待儿童史的青少年)。虐待儿童与青少年密切相关
自杀意念和行为;然而,单独虐待儿童是未来自杀意念的不良预测因素,
行为预测未来的自杀意念和行为是至关重要的,目前可能受到缺乏
关于已知自杀风险因素的神经基础的知识。虐待儿童会影响
在大脑中与情绪调节有关的区域发挥作用。此外,情绪调节可能是一个关键过程,
潜在的自杀想法和行为拟议的研究将前瞻性地检查网络范围
脑网络中与情绪调节有关的功能连接作为自杀意念的预测因素
两个独立的样本,有和没有虐待儿童的历史。这项工作将探索
额缘(例如,背外侧前额叶皮层-杏仁核)的连接性
有无自杀意念和虐待儿童青少年的调节任务和静息状态扫描
历史此外,这项工作将检查神经连接作为自杀意念的前瞻性预测因子。
根据以往的研究,预计同时存在虐待儿童和自杀意念的青少年
历史将证明与儿童虐待或虐待儿童的青少年相比,
自杀意念史和对照组青年。此外,据推测,弱额缘
在两个青年样本中,连接性将前瞻性地预测约1-2年内的自杀意念。这里
我们有非凡的能力交叉验证我们的发现,从一个独立的样本,
青年使用基于实验室的范例,功能网络连接和
创新的纵向,交叉验证的结果,拟议的研究提供了一个实质性的进步,
这个领域几乎完全依赖于自杀的横截面,单一的线人,回顾性报告,
构思能力来自两个独立样本的参与者(共N = 340名8-16岁的青少年;数据收集支持
由2名NIMH资助的R 01),有一系列儿童虐待和自杀意念史,完成基线
评估和fMRI扫描,前瞻性随访约1-2年,并完成额外的fMRI扫描。
我们将结合联合收割机传统的连通性分析(图论)和尖端的数据驱动算法,
交叉验证基线和随访(约1-2年)的神经网络连接结果。Findings from the
目前的研究可以确定自杀意念和行为风险的具体标志,使我们能够显著地
改善前瞻性预测。提高对青少年自杀的神经基础的认识是至关重要的
解决这一重大公共卫生问题。该项目直接响应国家行动呼吁
并将为这一领域做出重大贡献。
项目成果
期刊论文数量(13)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Adam Bryant Miller其他文献
Risk and Protective Effects of Need for Approval on Self-Injury in Adolescent Girls
- DOI:
10.1007/s10578-024-01779-y - 发表时间:
2024-11-14 - 期刊:
- 影响因子:2.200
- 作者:
Rebekah B. Clapham;Zihua Ye;Leah H. Somerville;Adam Bryant Miller;Matteo Giletta;Paul D. Hastings;George M. Slavich;Matthew K. Nock;Mitchell J. Prinstein;Karen D. Rudolph - 通讯作者:
Karen D. Rudolph
Suicidal Thoughts and Behavior in Children and Adolescents: An Ecological Model of Resilience
- DOI:
10.1007/s40894-017-0066-z - 发表时间:
2017-09-05 - 期刊:
- 影响因子:8.100
- 作者:
Michelle L. Gallagher;Adam Bryant Miller - 通讯作者:
Adam Bryant Miller
27.4 EXPLORING MECHANISMS LINKING EXPOSURE TO DEPRIVATION AND THREAT IN EARLY CHILDHOOD WITH ADOLESCENT PSYCHOPATHOLOGY: LONGITUDINAL PATTERNS IN A NATIONAL SAMPLE
- DOI:
10.1016/j.jaac.2019.07.811 - 发表时间:
2019-10-01 - 期刊:
- 影响因子:
- 作者:
Adam Bryant Miller;Laura S. Machlin;Margaret A. Sheridan - 通讯作者:
Margaret A. Sheridan
Structural brain alterations associated with suicidal thoughts and behaviors in young people: results across 21 international studies from the ENIGMA Suicidal Thoughts and Behaviours consortium
与年轻人自杀想法和行为相关的大脑结构改变:ENIGMA 自杀想法和行为联盟 21 项国际研究的结果
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
L. V. van Velzen;M. Dauvermann;L. Colic;L. Villa;Hannah S. Savage;Y. Toenders;Alyssa H. Zhu;Joanna K. Bright;A. Campos;Lauren E. Salminen;Sonia Ambrogi;R. Ayesa;N. Banaj;Zeynep Başgöze;Jochen Bauer;Karina Blair;Robert James Blair;Katharina Brosch;Yuqi Cheng;R. Colle;Colm G. Connolly;Emmanuelle Corruble;B. Couvy;B. Crespo;Kathryn R. Cullen;U. Dannlowski;Christopher G. Davey;K. Dohm;Janice M. Fullerton;A. Gonul;I. Gotlib;D. Grotegerd;T. Hahn;Ben J. Harrison;Mengxin He;I. Hickie;T. Ho;F. Iorfino;Andreas Jansen;F. Jollant;T. Kircher;B. Klimes;M. Klug;E. Leehr;E. Lippard;Katie A McLaughlin;S. Meinert;Adam Bryant Miller;Philip B. Mitchell;B. Mwangi;I. Nenadić;Amar Ojha;B. Overs;J. Pfarr;F. Piras;K. Ringwald;Gloria Roberts;G. Romer;M. Sanches;M. Sheridan;J. Soares;G. Spalletta;F. Stein;Giana I. Teresi;D. Tordesillas;Aslihan Uyar;N. J. van der Wee;S. V. D. van der Werff;R. Vermeiren;A. Winter;Mon;Tony T. Yang;P. Thompson;M. Rentería;N. Jahanshad;Hilary P. Blumberg;A. van Harmelen;L. Schmaal - 通讯作者:
L. Schmaal
Adam Bryant Miller的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Adam Bryant Miller', 18)}}的其他基金
Longitudinal examination of emotional reactivity and reactive aggression linking threat exposure with childhood self-injurious thoughts and behaviors
将威胁暴露与儿童自伤思想和行为联系起来的情绪反应和反应性攻击的纵向检查
- 批准号:
10734437 - 财政年份:2023
- 资助金额:
$ 17.98万 - 项目类别:
Testing the predictive power of neural connectivity: Suicidal ideation in youth exposed to maltreatment
测试神经连接的预测能力:遭受虐待的青少年的自杀意念
- 批准号:
9898475 - 财政年份:2018
- 资助金额:
$ 17.98万 - 项目类别:
Child Trauma, Neural Systems Underlying Emotion Regulation, and Adolescent Suicide
儿童创伤、情绪调节的神经系统和青少年自杀
- 批准号:
8978230 - 财政年份:2015
- 资助金额:
$ 17.98万 - 项目类别:
Child Trauma, Neural Systems Underlying Emotion Regulation, and Adolescent Suicide
儿童创伤、情绪调节的神经系统和青少年自杀
- 批准号:
9135967 - 财政年份:2015
- 资助金额:
$ 17.98万 - 项目类别:
相似海外基金
Understanding How Adolescent Bullying Experiences Affect Traumatic Stress,Sexual Health and STI Risk among Men Who Have Sex with Men (MSM)
了解青少年欺凌经历如何影响男男性行为者 (MSM) 的创伤性压力、性健康和性传播感染风险
- 批准号:
10553263 - 财政年份:2022
- 资助金额:
$ 17.98万 - 项目类别:
Understanding How Adolescent Bullying Experiences Affect Traumatic Stress,Sexual Health and STI Risk among Men Who Have Sex with Men (MSM)
了解青少年欺凌经历如何影响男男性行为者 (MSM) 的创伤性压力、性健康和性传播感染风险
- 批准号:
10347813 - 财政年份:2022
- 资助金额:
$ 17.98万 - 项目类别:
Visuocortical Dynamics of Affect-Biased Attention in the Development of Adolescent Depression
青少年抑郁症发展过程中情感偏向注意力的视觉皮层动力学
- 批准号:
10380686 - 财政年份:2019
- 资助金额:
$ 17.98万 - 项目类别:
Visuocortical Dynamics of Affect-Biased Attention in the Development of Adolescent Depression
青少年抑郁症发展过程中情感偏向注意力的视觉皮层动力学
- 批准号:
9888437 - 财政年份:2019
- 资助金额:
$ 17.98万 - 项目类别:
Visuocortical Dynamics of Affect-Biased Attention in the Development of Adolescent Depression
青少年抑郁症发展过程中情感偏向注意力的视觉皮层动力学
- 批准号:
10597082 - 财政年份:2019
- 资助金额:
$ 17.98万 - 项目类别:
Targeting maladaptive responding to negative affect in adolescent cannabis users
针对青少年大麻使用者的负面影响的适应不良反应
- 批准号:
9371970 - 财政年份:2017
- 资助金额:
$ 17.98万 - 项目类别:
Childhood positive affect and anger as predictors of adolescent risky behavior
童年积极影响和愤怒是青少年危险行为的预测因素
- 批准号:
9139461 - 财政年份:2015
- 资助金额:
$ 17.98万 - 项目类别:
Do State Marijuana Policies Affect Adolescent Marijuana and Alcohol Use?
州大麻政策会影响青少年大麻和酒精的使用吗?
- 批准号:
8783159 - 财政年份:2014
- 资助金额:
$ 17.98万 - 项目类别:
Do State Marijuana Policies Affect Adolescent Marijuana and Alcohol Use?
州大麻政策会影响青少年大麻和酒精的使用吗?
- 批准号:
8853783 - 财政年份:2014
- 资助金额:
$ 17.98万 - 项目类别:
Assessment of Affect Instability in Adolescent Girls with BPD Features
具有 BPD 特征的青春期女孩的情绪不稳定评估
- 批准号:
8122499 - 财政年份:2011
- 资助金额:
$ 17.98万 - 项目类别: